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MFF Antibody

  • 货号：
    CSB-PA834434
  • 规格：
    ￥1100
  • 图片：
    • The image on the left is immunohistochemistry of paraffin-embedded Human liver cancer tissue using CSB-PA834434(MFF Antibody) at dilution 1/25, on the right is treated with synthetic peptide. (Original magnification: ×200)
    • The image on the left is immunohistochemistry of paraffin-embedded Human prostate cancer tissue using CSB-PA834434(MFF Antibody) at dilution 1/25, on the right is treated with synthetic peptide. (Original magnification: ×200)
  • 其他：

产品详情

  • Uniprot No.：
    Q9GZY8
  • 基因名：
    MFF
  • 别名：
    C2orf33 antibody; Chromosome 2 open reading frame 33 antibody; DKFZp666J168 antibody; GL004 antibody; Mff antibody; MFF_HUMAN antibody; MGC110913 antibody; Mitochondrial fission factor antibody; OTTHUMP00000164235 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse,Rat
  • 免疫原：
    Synthetic peptide of Human MFF
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen affinity purification
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,IHC
  • 推荐稀释比：
    Application Recommended Dilution
    ELISA 1:1000-1:2000
    IHC 1:25-1:100
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Plays a role in mitochondrial and peroxisomal fission. Promotes the recruitment and association of the fission mediator dynamin-related protein 1 (DNM1L) to the mitochondrial surface. May be involved in regulation of synaptic vesicle membrane dynamics by recruitment of DNM1L to clathrin-containing vesicles.
  • 基因功能参考文献：
    1. Data show that increasing dynamin-related protein 1 (Drp1) SUMOylation by knocking down SUMO1-sentrin-SMT3 specific protease 3 (SENP3) reduces both Drp1 binding to mitochondrial fission factor protein (Mff) and stress-induced cytochrome c release. PMID: 28262828
    2. expressions of TIA-1 and MFF were augmented in the cancerous liver tissues compared to the corresponding non-tumor tissues at mRNA and protein level, while the levels of miR-200a-3p and miR-27a/b were relatively lower in the cancerous liver tissues PMID: 29496454
    3. We suggest that, even if laboratory findings are not indicative of mitochondrial or peroxisomal dysfunction, the co-occurrence of optic and/or peripheral neuropathy with seizures warrants genetic testing for MFF mutations PMID: 26783368
    4. membrane-anchored Mff differentially regulates various Drp1 isoforms. PMID: 26578513
    5. Data show that expression of MFF protein, miR-593-5p and BRCA1 protein correlates with cisplatin sensitivity and survival of tongue squamous cell carcinoma (TSCC). PMID: 25912308
    6. loss of Mff results in failure of Parkin translocation and final clearance of damaged mitochondria PMID: 26008206
    7. Mitochondrial fission factor (MFF) mRNA is a direct target of miR-27, whose ectopic expression decreases MFF expression through binding to its 3'-untranslated region. PMID: 25431021
    8. TRAP1 controls mitochondrial fusion/fission balance through Drp1 and Mff expression. PMID: 23284813
    9. PEX11 proteins attract both Mff and human Fis1 (hFis1) to their site of action. PMID: 22595523
    10. MFF over-expression results in extensive mitochondrial fragmentation, driving mitochondrial dysfunction. MFF fibroblasts undergo oxidative stress, with increased ROS production, and the onset of autophagy and mitophagy. PMID: 22878233
    11. MFF gene expression is decreased in both classic and follicular variants of papillary thyroid carcinoma. PMID: 21509594
    12. Mff is a novel component of a conserved membrane fission pathway used for constitutive and induced fission of mitochondria and peroxisomes. PMID: 18353969

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  • 相关疾病：
    Encephalopathy due to defective mitochondrial and peroxisomal fission 2 (EMPF2)
  • 亚细胞定位：
    Mitochondrion outer membrane; Single-pass type IV membrane protein. Peroxisome. Cytoplasmic vesicle, secretory vesicle, synaptic vesicle.
  • 蛋白家族：
    Tango11 family
  • 组织特异性：
    Highly expressed in heart, kidney, liver, brain, muscle, and stomach.
  • 数据库链接：

    HGNC: 24858

    OMIM: 614785

    KEGG: hsa:56947

    STRING: 9606.ENSP00000302037

    UniGene: Hs.471528