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METTL14 Antibody

  • 货号：
    CSB-PA884519LA01HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Western Blot
      Positive WB detected in: SH-SY5Y whole cell lysate
      All lanes: METTL14 antibody at 1:1000
      Secondary
      Goat polyclonal to rabbit IgG at 1/50000 dilution Predicted band size: 53 kDa
      Observed band size: 53 kDa
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) METTL14 Polyclonal antibody
  • Uniprot No.：
    Q9HCE5
  • 基因名：
  • 别名：
    KIAA1627 antibody; MET14_HUMAN antibody; Methyltransferase like 14 antibody; Methyltransferase-like protein 14 antibody; METTL14 antibody; N6-adenosine-methyltransferase subunit METTL14 antibody; OTTHUMP00000219837 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Recombinant Human N6-adenosine-methyltransferase subunit METTL14 protein (24-206AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated

    本页面中的产品，METTL14 Antibody (CSB-PA884519LA01HU)，的标记方式是Non-conjugated。对于METTL14 Antibody，我们还提供其他标记。见下表：

    可提供标记
    标记方式 货号 产品名称 应用
    HRP CSB-PA884519LB01HU METTL14 Antibody, HRP conjugated ELISA
    FITC CSB-PA884519LC01HU METTL14 Antibody, FITC conjugated
    Biotin CSB-PA884519LD01HU METTL14 Antibody, Biotin conjugated ELISA
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    >95%, Protein G purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, WB
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:500-1:3000
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    The METTL3-METTL14 heterodimer forms a N6-methyltransferase complex that methylates adenosine residues at the N(6) position of some mRNAs and regulates the circadian clock, differentiation of embryonic stem cells and cortical neurogenesis. In the heterodimer formed with METTL3, METTL14 constitutes the RNA-binding scaffold that recognizes the substrate rather than the catalytic core. N6-methyladenosine (m6A), which takes place at the 5'-[AG]GAC-3' consensus sites of some mRNAs, plays a role in mRNA stability and processing. M6A acts as a key regulator of mRNA stability by promoting mRNA destabilization and degradation. In embryonic stem cells (ESCs), m6A methylation of mRNAs encoding key naive pluripotency-promoting transcripts results in transcript destabilization. M6A regulates spermatogonial differentiation and meiosis and is essential for male fertility and spermatogenesis. M6A also regulates cortical neurogenesis: m6A methylation of transcripts related to transcription factors, neural stem cells, the cell cycle and neuronal differentiation during brain development promotes their destabilization and decay, promoting differentiation of radial glial cells.
  • 基因功能参考文献：
    1. methyltransferase-like protein 14 in a complex with METTL3 mediates nuclear RNA methylation PMID: 24316715
  • 亚细胞定位：
    Nucleus.
  • 蛋白家族：
    MT-A70-like family
  • 数据库链接：

    HGNC: 29330

    OMIM: 616504

    KEGG: hsa:57721

    STRING: 9606.ENSP00000373474

    UniGene: Hs.596872