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  4. METRNL Antibody
  • 货号：
    CSB-PA731035LA01HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Western Blot
      Positive WB detected in: Hela whole cell lysate, U87 whole cell lysate, K562 whole cell lysate, PC3 whole cell lysate, Mouse brain tissue, Rat kidney tissue, Rat brain tissue
      All lanes: METRNL antibody at 1:2000
      Secondary
      Goat polyclonal to rabbit IgG at 1/50000 dilution
      Predicted band size: 35, 26 KDa
      Observed band size: 35 KDa
      Exposure time：1min
  • 其他：

产品详情

  • 产品描述：

    The METRNL antibody was raised in rabbits using the recombinant human METRNL protein as the immunogen. It underwent antigen affinity purification. This rabbit anti-human METRNL polyclonal antibody exhibits high specificity for METRNL protein from human, mouse, and rat samples. The target protein METRNL is a novel adipokine that has been shown to play a role in metabolic regulation, insulin sensitivity, and energy homeostasis.

    This antibody can be used in ELISA and WB applications. And it may be useful in metabolic disorders and related fields.

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) METRNL Polyclonal antibody
  • Uniprot No.：
    Q641Q3
  • 基因名：
    METRNL
  • 别名：
    Meteorin like glial cell differentiation regulator antibody; Meteorin; glial cell differentiation regulator like antibody; Meteorin-like protein antibody; METRL_HUMAN antibody; Metrnl antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human, Mouse, Rat
  • 免疫原：
    Recombinant Human Meteorin-like protein
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated

    本页面中的产品，METRNL Antibody (CSB-PA731035LA01HU)，的标记方式是Non-conjugated。对于METRNL Antibody，我们还提供其他标记。见下表：

    可提供标记
    标记方式 货号 产品名称 应用
    HRP CSB-PA731035LB01HU METRNL Antibody, HRP conjugated ELISA
    FITC CSB-PA731035LC01HU METRNL Antibody, FITC conjugated
    Biotin CSB-PA731035LD01HU METRNL Antibody, Biotin conjugated ELISA
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen Affinity purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, WB
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:500-1:5000
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

平均分:
5.0分 - 2 个评价

实验应用：WB

样品信息：组织裂解液（lysate），小鼠肝脏

稀释比：1：1000

产品评价： 我使用CSB-PA731035LA01HU抗体，进行WB）检测，检测小鼠肝脏组织样本，样本处理情况为60hz研磨仪研磨五分钟，其结果为附图，条带清晰无杂带，特异性好。

By 罗老师

实验应用：WB

样品信息：骨骼组织及骨骼肌原代细胞，大鼠

稀释比：1:5000

产品评价： 使用CSB-PA731035LA01HU抗体，进行WB）检测，检测大鼠骨骼肌组织和骨骼肌原代细胞，稀释比为1:5000，其结果见附图，可见条带清晰无杂带，位置正确，特异性好。

By 颜老师

靶点详情

  • 功能：
    Hormone induced following exercise or cold exposure that promotes energy expenditure. Induced either in the skeletal muscle after exercise or in adipose tissue following cold exposure and is present in the circulation. Able to stimulate energy expenditure associated with the browning of the white fat depots and improves glucose tolerance. Does not promote an increase in a thermogenic gene program via direct action on adipocytes, but acts by stimulating several immune cell subtypes to enter the adipose tissue and activate their prothermogenic actions. Stimulates an eosinophil-dependent increase in IL4 expression and promotes alternative activation of adipose tissue macrophages, which are required for the increased expression of the thermogenic and anti-inflammatory gene programs in fat. Required for some cold-induced thermogenic responses, suggesting a role in metabolic adaptations to cold temperatures.
  • 基因功能参考文献：
    1. downregulation of METRNL during adipogenesis and functional induction of increased proliferation in stromal vascular fraction cells with concomitant inhibition of adipocyte differentiation may result in hypertrophic AT accumulation PMID: 27748745
    2. Overexpression of METRNL inhibited mineralized nodule formation. PMID: 27716826
    3. Data suggest that there is no correlation between serum Metrnl levels and BMI (body mass index) in humans. PMID: 26307585
    4. Results show that Subfatin is a novel adipokine regulated by adipogenesis and obesity, with tissue distribution different from its homologue Meteorin PMID: 24393292
  • 亚细胞定位：
    Secreted.
  • 蛋白家族：
    Meteorin family
  • 组织特异性：
    Highly expressed in the skeletal muscle, in subcutaneous adipose tissue, epididymal white adipose tissue depots and heart. Also expressed in brown adipose tissues and kidney.
  • 数据库链接：

    HGNC: 27584

    OMIM: 616241

    KEGG: hsa:284207

    STRING: 9606.ENSP00000315731

    UniGene: Hs.378821