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MEST Antibody

  • 货号：
    CSB-PA704858ESR2HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Immunohistochemistry of paraffin-embedded human breast cancer using CSB-PA704858ESR2HU at dilution of 1:100
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) MEST Polyclonal antibody
  • Uniprot No.：
    Q5EB52
  • 基因名：
    MEST
  • 别名：
    MEST; PEG1; Mesoderm-specific transcript homolog protein; Paternally-expressed gene 1 protein
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Recombinant Human Mesoderm-specific transcript homolog protein (146-335AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen Affinity Purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, IHC
  • 推荐稀释比：
    Application Recommended Dilution
    IHC 1:20-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 基因功能参考文献：
    1. We conclude methylation changes at some CpG sites of MEST and DLK differentially methylated regions in preeclamptic group PMID: 29157033
    2. Some growth-regulating imprinted genes such as MEST and MEG3, are susceptible to non-imprinted allele during development and differentiation, whereas the intergenic differentially methylated region of others (i.e. PEG3) are strictly maintained. PMID: 28854270
    3. strongly expressed in invasive extravillous trophoblasts during the first trimester PMID: 27697227
    4. G4 formation at motifs not previously identified through bioinformatic analysis of the MEST promoter, is reported. PMID: 28052120
    5. altered DNA methylation at imprinted domains including IGF2/H19 and PEG1/MEST may mediate the association between human papillomavirus infection and invasive cervical cancer PMID: 23775149
    6. The expression levels of miR-335 significantly correlated with those of MEST, supporting the notion that the intronic miR-335 is co-expressed with its host gene PMID: 23229728
    7. DNA methylation level at the H19 and MEST differentially methylated regions (DMRs)is reduced in placentas from pregnancies conceived by IVF/ICSI when compared with placentas from spontaneous conception. PMID: 23343754
    8. Paternal methylation aberrations at imprinting control regions of DLK1-GTL2, MEST (PEG1), and ZAC (PLAGL1) and global methylation levels are not associated with idiopathic recurrent spontaneous miscarriages. PMID: 23415968
    9. These results support the idea that intrauterine exposure to gestational diabetes mellitus has long-lasting effects on the epigenome of the offspring. PMID: 23209187
    10. MEST showed tissue-specific imprinting, being paternally expressed in skeletal muscle, fat, pituitary gland, heart, kidney, lung, stomach and uterus, and maternally expressed in spleen and liver. PMID: 22531794
    11. In cortices, the MEST promoter was hemimethylated, as expected for a differentially methylated imprinting control region, whereas the COPG2 and TSGA14 promoters were completely demethylated, typical for transcriptionally active non-imprinted genes. PMID: 22456293
    12. Regardless of conception method, the PEG1 methylation percentage in chorionic villus from spontaneous abortions is significantly higher than in villus from induced abortions and multifetal reduction. PMID: 21575949
    13. data demonstrated that tumorigenesis of leiomyoma is associated with overexpression of isoform 1 of PEG1/MEST gene, but not with loss of imprinting of the gene PMID: 20339302
    14. MEST gene is imprinted in an isoform-specific manner in adult lymphocytes. PMID: 10631159
    15. MEST gene is imprinted, with preferential expression from the paternal allele in fetal tissues. PMID: 9192843
    16. Findings suggest that PEG1/MEST can be excluded as a major determinant of Silver-Russell syndrome. PMID: 11754049
    17. An imprinted PEG1/MEST antisense expressed predominantly in human testis and in mature spermatozoa. PMID: 11821432
    18. Mutation screening and imprinting analysis of candidate genes for autism in the 7q32 region PMID: 11920156
    19. a novel mechanism /promoter switch/ leading to biallelic expression in invasive breast cancer PMID: 12023987
    20. An intron contains a sequence, MESTIT1, which is transcribed only from the paternal allele, may be involved in MEST regulation PMID: 12095916
    21. Lof imprinting of PEG1/MESTOI may be related to tumorigenesis and malignant transformation, especially in NSCLC PMID: 15547750
    22. PEG1 isoform 2 is in fact imprinted in a large subset of human placentae. PMID: 16338457
    23. Hypermethylation of paternally expressed genes including PEG1/MEST, which have growth-promoting effects, may be relevant to low birth weight in subjects conceived by assisted reproduction techniques. PMID: 17450433
    24. Type of epimutation at the PEG1/MEST locus does not play a relevant role in Silver-Russell syndrome. PMID: 18585117
    25. MEST is localized to the endoplasmic reticulum/Golgi apparatus where its putative enzymatic properties as a lipase or acyltransferase, predicted from sequence homology with members of the alpha/beta fold hydrolase superfamily. PMID: 18644838

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  • 亚细胞定位：
    Endoplasmic reticulum membrane; Multi-pass membrane protein.
  • 蛋白家族：
    AB hydrolase superfamily
  • 组织特异性：
    Highly expressed in hydatidiform moles, but barely expressed in dermoid cysts. Biallelic expression is detected in blood lymphocytes. Seems to imprinted in an isoform-specific manner rather than in a tissue-specific manner in lymphocytes. Isoform 1 is exp
  • 数据库链接：

    HGNC: 7028

    OMIM: 601029

    KEGG: hsa:4232

    STRING: 9606.ENSP00000223215

    UniGene: Hs.270978