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MESP1 Antibody

  • 货号：
    CSB-PA871559ESR2HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Immunohistochemistry of paraffin-embedded human pancreatic tissue using CSB-PA871559ESR2HU at dilution of 1:100
    • Immunohistochemistry of paraffin-embedded human pancreatic cancer using CSB-PA871559ESR2HU at dilution of 1:100
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) MESP1 Polyclonal antibody
  • Uniprot No.：
    Q9BRJ9
  • 基因名：
    MESP1
  • 别名：
    bHLHc5 antibody; Class C basic helix-loop-helix protein 5 antibody; Mesoderm posterior 1 antibody; Mesoderm posterior 1 homolog (mouse) antibody; Mesoderm posterior 1 homolog antibody; Mesoderm posterior protein 1 antibody; MESP 1 antibody; Mesp1 antibody; MESP1_HUMAN antibody; MGC10676 antibody; MGC159208 antibody; MGC159210 antibody; OTTMUSP00000030151 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Recombinant Human Mesoderm posterior protein 1 protein (149-268AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen Affinity Purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, IHC
  • 推荐稀释比：
    Application Recommended Dilution
    IHC 1:20-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Transcription factor. Plays a role in the epithelialization of somitic mesoderm and in the development of cardiac mesoderm. Defines the rostrocaudal patterning of the somites by participating in distinct Notch pathways.
  • 基因功能参考文献：
    1. The present study firstly provided experimental evidence supporting the concept that a MESP1 lossoffunction mutation may contribute to the development of double outlet right ventricle in humans, which presents a significant insight into the molecular pathogenesis of congenital heart disease. PMID: 28677747
    2. results suggest that pathologic variants in MESP1 may contribute to the development of congenital heart disease (CHD) and that additional protein partners and downstream targets could likewise contribute to the wide range of causes for CHD PMID: 26694203
    3. The MESP1-NKX2-5 hESC reporter line allows us to identify molecular cues crucial for specification and expansion of human cardiac mesoderm and early progenitors and their differentiation to specific cardiovascular derivatives. PMID: 25187301
    4. MESP1 SNPs are associated with congenital heart disease in patients and altered transcription in vitro. PMID: 24056064
    5. Transcription factors ETS2 and MESP1 transdifferentiate human dermal fibroblasts into cardiac progenitors. PMID: 22826236
    6. MesP1 drives vertebrate cardiovascular differentiation through Dkk-1-mediated blockade of Wnt-signalling PMID: 18297060

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  • 亚细胞定位：
    Nucleus.
  • 数据库链接：

    HGNC: 29658

    OMIM: 608689

    KEGG: hsa:55897

    STRING: 9606.ENSP00000300057

    UniGene: Hs.447531