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MEP1B Antibody

  • 货号：
    CSB-PA618098ESR1HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Western blot
      All lanes: MEP1B antibody IgG at 2.36μg/ml + Mouse kidney tissue
      Secondary
      Goat polyclonal to rabbit IgG at 1/10000 dilution
      Predicted band size: 80 kDa
      Observed band size: 80 kDa
    • Immunohistochemistry of paraffin-embedded human small intestine tissue using CSB-PA618098ESR1HU at dilution of 1:100
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) MEP1B Polyclonal antibody
  • Uniprot No.：
    Q16820
  • 基因名：
    MEP1B
  • 别名：
    Endopeptidase 2 antibody; Endopeptidase-2 antibody; kinase splitting membranal proteinase antibody; KSMP antibody; Mep1b antibody; MEP1B_HUMAN antibody; Meprin 1 beta subunit antibody; Meprin A beta antibody; Meprin A beta subunit precursor antibody; Meprin A subunit beta antibody; Meprin B antibody; N benzoyl L tyrosyl P amino benzoic acid hydrolase beta subunit antibody; N-benzoyl-L-tyrosyl-P-amino-benzoic acid hydrolase subunit beta antibody; PABA peptide hydrolase antibody; PPH beta antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human, Mouse
  • 免疫原：
    Recombinant Human Meprin A subunit beta protein (480-652AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen Affinity Purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, WB, IHC
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:1000-1:5000
    IHC 1:20-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Membrane metallopeptidase that sheds many membrane-bound proteins. Exhibits a strong preference for acidic amino acids at the P1' position. Known substrates include: FGF19, VGFA, IL1B, IL18, procollagen I and III, E-cadherin, KLK7, gastrin, ADAM10, tenascin-C. The presence of several pro-inflammatory cytokine among substrates implicate MEP1B in inflammation. It is also involved in tissue remodeling due to its capability to degrade extracellular matrix components.
  • 基因功能参考文献：
    1. Results provide evidence that meprin beta is involved in collagen deposition in vivo in the lung of bleomycin treated mice and it localized in region with immature collagen. This suggests that meprin beta can favor the progression of the fibrotic process enhancing collagen processing and deposition. PMID: 28059112
    2. This secreted cysteine protease potently converts membrane-bound meprin beta into its active form, impairing meprin beta shedding and its function as a mucus-detaching protease PMID: 29166602
    3. For meprin beta a reduction and for BMP-1 an increase in activity was reported under increasing calcium concentrations. PMID: 28365001
    4. TSPAN8 might be important for the orchestration of meprin beta at the cell surface with impact on certain proteolytic processes PMID: 27180358
    5. n conclusion, we show that the concept of cleavable linkers specific for meprin beta is feasible, as the peptides are rapidly cleaved by the enzyme while retaining their biological properties PMID: 25855967
    6. Meprin Beta was found to be activated at the cell surface by matriptase-2. PMID: 26251449
    7. promotes inflammation in macrophages via ADAM-10 dependent pathway PMID: 24239627
    8. Overexpression of MEP1B is associated with pancreatic neuroendocrine tumors. PMID: 24114056
    9. Suggest role for in meprin-beta-Fra2 axis in mediating vascular remodelling in pulmonary hypertension. PMID: 24258247
    10. of the 151 new extracellular substrates identified, it was notable that ADAM10 the constitutive alpha-secretase-is activated by meprin beta through cleavage of the propeptide PMID: 22940918
    11. metalloprotease meprin beta generates amino terminal-truncated amyloid beta peptide species PMID: 22879596
    12. Processing of APP by meprin beta was subsequently validated using in vitro and in vivo approaches. N-terminal APP fragments of about 11 and 20 kDa were found in human and mouse brain lysates but not in meprin beta(-/-) mouse brain lysates PMID: 21646356
    13. Demonstrate that the metalloprotease meprin beta and gamma-ENaC associate directly through cytoplasmic domains. PMID: 20953144
    14. data indicate that, at least under pathological conditions, meprinbeta might attack specific functional sites in tenascin-C that are important for its oligomerization and anti-adhesive activity PMID: 19748582
    15. results show that the O-linked carbohydrate side chains in hmeprinbeta are clustered around a 13 amino acid sequence that contains the main cleavage site for proteolytic processing of the subunit PMID: 12387727
    16. two different metalloprotease activities are responsible for the constitutive and the PMA-stimulated hmeprinbeta shedding PMID: 12941954

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  • 亚细胞定位：
    Cell membrane; Single-pass type I membrane protein. Secreted.
  • 蛋白家族：
    Peptidase M12A family
  • 组织特异性：
    The major site of expression is the brush border membrane of small intestinal and kidney epithelial cells.
  • 数据库链接：

    HGNC: 7020

    OMIM: 600389

    KEGG: hsa:4225

    STRING: 9606.ENSP00000269202

    UniGene: Hs.194777