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MEMO1 Antibody

  • 货号：
    CSB-PA896500ESR1HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Immunohistochemistry of paraffin-embedded human thyroid tissue using CSB-PA896500ESR1HU at dilution of 1:100
    • Immunohistochemistry of paraffin-embedded human colon cancer using CSB-PA896500ESR1HU at dilution of 1:100
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) MEMO1 Polyclonal antibody
  • Uniprot No.：
    Q9Y316
  • 基因名：
    MEMO1
  • 别名：
    C21orf19-like protein antibody; C2orf4 antibody; CGI 27 antibody; DKFZp434I0135 antibody; FLJ25031 antibody; HCV NS5A-transactivated protein 7 antibody; Hepatitis C virus NS5A-transactivated protein 7 antibody; Mediator of cell motility 1 antibody; Mediator of ErbB2-driven cell motility 1 antibody; MEMO antibody; Memo-1 antibody; memo1 antibody; MEMO1_HUMAN antibody; NS5ATP7 antibody; Protein MEMO1 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Recombinant Human Protein MEMO1 protein (1-297AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen Affinity Purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, IHC
  • 推荐稀释比：
    Application Recommended Dilution
    IHC 1:20-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    May control cell migration by relaying extracellular chemotactic signals to the microtubule cytoskeleton. Mediator of ERBB2 signaling. The MEMO1-RHOA-DIAPH1 signaling pathway plays an important role in ERBB2-dependent stabilization of microtubules at the cell cortex. It controls the localization of APC and CLASP2 to the cell membrane, via the regulation of GSK3B activity. In turn, membrane-bound APC allows the localization of the MACF1 to the cell membrane, which is required for microtubule capture and stabilization. Is required for breast carcinoma cell migration.
  • 基因功能参考文献：
    1. Study identify Memo as an important key mediator between the heregulin and estrogen signaling pathways, which affects both breast cancer cell migration and proliferation. PMID: 27472465
    2. HRG/HER2/HER3 signaling promotes AhR-mediated Memo-1 expression and migration in colorectal cancer PMID: 27941874
    3. Biochemical assays revealed that Memo is a copper-dependent redox enzyme that promoted a more oxidized intracellular milieu and stimulated the production of reactive oxygen species (ROS) in cellular structures involved in migration. PMID: 24917593
    4. Mediator of ERBB2-driven cell motility (MEMO) promotes extranuclear estrogen receptor signaling involving the growth factor receptors IGF1R and ERBB2. PMID: 23861392
    5. MEMO1 is involved in breast carcinogenesis via regulating insulin-like growth factor-I receptor-dependent signaling events. PMID: 22824790
    6. data suggest that Memo controls cell migration by relaying extracellular chemotactic signals to the microtubule cytoskeleton [Memo] PMID: 15156151
    7. 2.1A crystal structure and homology to class III nonheme iron-dependent dioxygenases PMID: 18045866
    8. Memo-RhoA-mDia1 signaling coordinates the organization of the lamellipodial actin network, adhesion site formation, and microtubule outgrowth within the cell leading edge to sustain cell motility. PMID: 18955552
    9. Memo was detected in complexes with cofilin, ErbB2 and PLCgamma1. PMID: 19223396

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  • 蛋白家族：
    MEMO1 family
  • 数据库链接：

    HGNC: 14014

    OMIM: 611786

    KEGG: hsa:51072

    STRING: 9606.ENSP00000295065

    UniGene: Hs.444969