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MEIS2 Antibody

  • 货号：
    CSB-PA013687GA01HU
  • 规格：
    ￥3,900
  • 其他：

产品详情

  • Uniprot No.：
    O14770
  • 基因名：
    MEIS2
  • 别名：
    Homeobox protein Meis2 antibody; HsT18361 antibody; Meis (mouse) homolog 2 antibody; Meis homeobox 2 antibody; Meis homolog 2 antibody; Meis1 myeloid ecotropic viral integration site 1 homolog 2 (mouse) antibody; Meis1 myeloid ecotropic viral integration site 1 homolog 2 antibody; Meis1 related gene 1 antibody; Meis1 related protein 1 antibody; Meis1-related protein 1 antibody; MEIS2 antibody; MEIS2_HUMAN antibody; MGC2820 antibody; MRG1 antibody; TALE homeobox protein Meis2 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse,Rat
  • 免疫原：
    Human MEIS2
  • 免疫原种属：
    Homo sapiens (Human)
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen Affinity Purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,WB,IHC
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Involved in transcriptional regulation. Binds to HOX or PBX proteins to form dimers, or to a DNA-bound dimer of PBX and HOX proteins and thought to have a role in stabilization of the homeoprotein-DNA complex. Isoform 3 is required for the activity of a PDX1:PBX1b:MEIS2b complex in pancreatic acinar cells involved in the transcriptional activation of the ELA1 enhancer; the complex binds to the enhancer B element and cooperates with the transcription factor 1 complex (PTF1) bound to the enhancer A element; MEIS2 is not involved in complex DNA-binding. Probably in complex with PBX1, is involved in transcriptional regulation by KLF4. Isoform 3 and isoform 4 can bind to a EPHA8 promoter sequence containing the DNA motif 5'-CGGTCA-3'; in cooperation with a PBX protein (such as PBX2) is proposed to be involved in the transcriptional activation of EPHA8 in the developing midbrain. May be involved in regulation of myeloid differentiation. Can bind to the DNA sequence 5'-TGACAG-3'in the activator ACT sequence of the D(1A) dopamine receptor (DRD1) promoter and activate DRD1 transcription; isoform 5 cannot activate DRD1 transcription.
  • 基因功能参考文献：
    1. High expression of MEIS2 impairs repressive DNA binding of AML1-ETO, inducing increased expression of genes such as the druggable proto-oncogene YES1. PMID: 27346355
    2. we have identified a novel nonsense MEIS2 mutation in a female patient with cleft palate, cardiac septal defect, severe ID, developmental delay and feeding difficulty with gastro-esophageal reflux. Our findings strongly suggest neurocristopathy be included in the clinical features associated with MEIS2 alterations. PMID: 27225850
    3. Meis2 as the target of miR-134 in the regulation of cardiomyocyte progenitor cell proliferation. PMID: 26512644
    4. This is the first report showing a de novo small intragenic mutation in MEIS2 and further confirms the important role of this gene in normal development. PMID: 25712757
    5. Our results show that MEIS2 is a gene needed for palate closure. In syndromic cases of cleft palate, MEIS2 should be considered among the candidate genes, for example, in cases without 22q11.2 deletions. PMID: 24678003
    6. FOXM1 is a direct target gene of MEIS2 and is required for MEIS2 to upregulate mitotic genes. PMID: 25210800
    7. Klf4 recruits a complex of Meis and Pbx proteins to DNA, resulting in Meis2 transcriptional activation domain-dependent activation of a subset of Klf4 target genes. PMID: 21746878
    8. The Single Nucleotide Polymorphism in Meis homeobox 2 (MEIS2) mediated the effects of risperidone on hip circumference (q=0.004). PMID: 20195266
    9. Transgenic mice lacking microRNAs miR-9-2 and miR-9-3 exhibit multiple defects of telencephalic structures which may be brought about by dysregulation of Foxg1, Nr2e1, Gsh2, and Meis2 expression. PMID: 21368052
    10. Data demonstrate by in situ hybridization and immunohistochemistry that the two homeobox genes Pax6 and MEIS2 are expressed during early fetal brain development in humans. PMID: 20523026
    11. This work suggests that the transcriptional activity of all members of the Meis/Prep Hth protein family is subject to autoinhibition by their Hth domains, and that the Meis3.2 splice variant encodes a protein that bypasses this autoinhibitory effect. PMID: 20553494
    12. Clinical trial and genome-wide association study of gene-disease association. (HuGE Navigator) PMID: 20195266
    13. Analysis of an Affymetrix data set in the public domain showed high expression of MEIS1 in human endometrium PMID: 18408019

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  • 相关疾病：
    Cleft palate, cardiac defects, and mental retardation (CPCMR)
  • 亚细胞定位：
    Nucleus. Cytoplasm, perinuclear region.
  • 蛋白家族：
    TALE/MEIS homeobox family
  • 组织特异性：
    Expressed in various tissues. Expressed at high level in the lymphoid organs of hematopoietic tissues. Also expressed in some regions of the brain, such as the putamen.
  • 数据库链接：

    HGNC: 7001

    OMIM: 600987

    KEGG: hsa:4212

    STRING: 9606.ENSP00000453793

    UniGene: Hs.510989