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MEF2B Antibody

  • 货号：
    CSB-PA013672GA01HU
  • 规格：
    ￥3,900
  • 其他：

产品详情

  • Uniprot No.：
    Q02080
  • 基因名：
  • 别名：
    MADS box transcription enhancer factor 2 antibody; MDS1 EVI1 antibody; Mef2b antibody; MEF2B_HUMAN antibody; Myocyte enhancer factor 2B antibody; Myocyte specific enhancer factor 2B antibody; Myocyte-specific enhancer factor 2B antibody; PRDM3 antibody; RSRFR2 antibody; Serum response factor like protein 2 antibody; Serum response factor-like protein 2 antibody; XMEF2 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Human MEF2B-Specific
  • 免疫原种属：
    Homo sapiens (Human)
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen Affinity purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,WB
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Transcriptional activator which binds specifically to the MEF2 element, 5'-YTA[AT](4)TAR-3', found in numerous muscle-specific genes. Activates transcription via this element. May be involved in muscle-specific and/or growth factor-related transcription.
  • 基因功能参考文献：
    1. Expression of J chain immunoglobulin and MEF2B are useful in differentiating classical Hodgkin lymphoma from nodular lymphocyte predominant Hodgkin lymphoma and primary mediastinal large B-cell lymphoma. PMID: 28851661
    2. K4E, Y69H and D83V mutations decrease the capacity of MEF2B to activate transcription and decrease its effects on cell migration. PMID: 26245647
    3. Epstein-Barr Virus EBNA1 bound to host genes of high significance for B-cell growth and function, including MEF2B, IL6R, and EBF1. PMID: 26468528
    4. We conclude that MEF2B is a valuable marker of normal germinal center B cells, potentially useful in differential diagnosis of small B cell lymphomas. PMID: 26089142
    5. MEF2B mutations lead to deregulated expression of the oncogene BCL6 in diffuse large B cell lymphoma. PMID: 23974956
    6. MEF2B has a role in myogenic transformation of the epithelial to a myofibroblast phenotype PMID: 22302709
    7. The phylogenetic tree result shows that MEF2B may be original because of its difference of sequences and evolutional relation. PMID: 21951798
    8. 32% of diffuse large B-cell lymphoma and 89% of follicular lymphoma cases had somatic mutations in MLL2, and 11.4% and 13.4% of DLBCL and FL cases, respectively, had mutations in MEF2B PMID: 21796119
    9. Observational study of gene-disease association. (HuGE Navigator) PMID: 19913121
    10. Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator) PMID: 20628086
    11. Crystal structure of the MADS-box/MEF2S domain of human MEF2B bound to a motif of the transcriptional co-repressor Cabin1 and DNA at 2.2 A resolution PMID: 12700764
    12. myogenin and myocyte enhancer factor-2 expression are triggered by membrane hyperpolarization during human myoblast differentiation PMID: 15084602
    13. The crystal structure of a histone deacetylase 9 (HDAC9)/myocyte enhancer factor-2 (MEF2)/DNA complex reveals that HDAC9 binds to a hydrophobic groove of the MEF2 dimer. PMID: 15567413
    14. Study demonstrates that human intestinal cell BCMO1 expression is dependent on the functional cooperation between peroxisome proliferator-activated receptor-gamma and myocyte enhancer factor 2 isoforms. PMID: 16504037
    15. MEF2 proteins are an important component in Galpha13-mediated angiogenesis. PMID: 19093215

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  • 亚细胞定位：
    Nucleus.
  • 蛋白家族：
    MEF2 family
  • 组织特异性：
    Expressed in skeletal and cardiac muscle and brain.
  • 数据库链接：

    HGNC: 6995

    OMIM: 600661

    KEGG: hsa:100271849

    STRING: 9606.ENSP00000162023

    UniGene: Hs.153629