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MED26 Antibody

  • 货号：
    CSB-PA013659LA01HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • IHC image of CSB-PA013659LA01HU diluted at 1:500 and staining in paraffin-embedded human testis tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) MED26 Polyclonal antibody
  • Uniprot No.：
    O95402
  • 基因名：
    MED26
  • 别名：
    Activator recruited cofactor 70 kDa component antibody; Activator-recruited cofactor 70 kDa component antibody; ARC 70 antibody; ARC70 antibody; Cofactor required for Sp1 transcriptional activation subunit 7 antibody; Cofactor required for Sp1 transcriptional activation, subunit 7 (70kD) antibody; Cofactor required for Sp1 transcriptional activation, subunit 7, 70kDa antibody; CRSP 7 antibody; CRSP complex subunit 7 antibody; CRSP70 antibody; MED 26 antibody; Med26 antibody; MED26_HUMAN antibody; Mediator complex subunit 26 antibody; Mediator of RNA polymerase II transcription subunit 26 antibody; Transcriptional coactivator CRSP70 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Recombinant Human Mediator of RNA polymerase II transcription subunit 26 protein (372-523AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated

    本页面中的产品，MED26 Antibody (CSB-PA013659LA01HU)，的标记方式是Non-conjugated。对于MED26 Antibody，我们还提供其他标记。见下表：

    可提供标记
    标记方式 货号 产品名称 应用
    HRP CSB-PA013659LB01HU MED26 Antibody, HRP conjugated ELISA
    FITC CSB-PA013659LC01HU MED26 Antibody, FITC conjugated
    Biotin CSB-PA013659LD01HU MED26 Antibody, Biotin conjugated ELISA
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    >95%, Protein G purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, IHC
  • 推荐稀释比：
    Application Recommended Dilution
    IHC 1:500-1:1000
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional pre-initiation complex with RNA polymerase II and the general transcription factors.
  • 基因功能参考文献：
    1. EAF1 (239-268) and TAF7 (205-235) peptide interactions were both mapped to the same groove formed by H3 and H4 helices of MED26 N-terminal domain. PMID: 28893534
    2. the MED26-NTD functions as a molecular switch in the exchange of TBP-associated factor 7 (TAF7) for LEC to facilitate the transition from initiation to elongation during transcription of a subset of snRNA genes PMID: 25575120
    3. MED26 can function as a molecular switch that interacts first with TFIID in the Pol II initiation complex and then exchanges TFIID for complexes containing ELL/EAF and P-TEFb to facilitate transition of Pol II into the elongation stage of transcription. PMID: 21729782
    4. Human CRSP interacts with RNA polymerase II CTD and adopts a specific CTD-bound conformation PMID: 12050112
    5. findings identify MED19/MED26 as a probable composite REST interface in Mediator and further clarify the mechanistic basis by which Mediator facilitates REST-imposed epigenetic restrictions on neuronal gene expression PMID: 19049968

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  • 亚细胞定位：
    Nucleus.
  • 蛋白家族：
    Mediator complex subunit 26 family
  • 数据库链接：

    HGNC: 2376

    OMIM: 605043

    KEGG: hsa:9441

    STRING: 9606.ENSP00000263390

    UniGene: Hs.715040