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MED17 Antibody

  • 货号：
    CSB-PA001793
  • 规格：
    ￥880
  • 图片：
    • Western Blot analysis of HT29 cells using CRSP77 Polyclonal Antibody
  • 其他：

产品详情

  • Uniprot No.：
    Q9NVC6
  • 基因名：
    MED17
  • 别名：
    77-KD subunit antibody; Activator recruited cofactor 77 kDa component antibody; Activator-recruited cofactor 77 kDa component antibody; ARC77 antibody; Cofactor required for Sp1 transcriptional activation subunit 6 antibody; cofactor required for Sp1 transcriptional activation, subunit 6, 77kDa antibody; CRSP complex subunit 6 antibody; CRSP6 antibody; CRSP77 antibody; DRIP80 antibody; med17 antibody; MED17_HUMAN antibody; Mediator complex subunit 17 antibody; Mediator of RNA polymerase II transcription subunit 17 antibody; Mediator of RNA polymerase II transcription subunit 17, S cerevisiae, homolog of antibody; Thyroid hormone receptor-associated protein complex 80 kDa component antibody; Thyroid hormone receptor-associated protein, 80-KD subunit antibody; Transcriptional coactivator CRSP77 antibody; Trap80 antibody; VITAMIN D RECEPTOR-INTERACTING PROTEIN, 80-KD antibody; Vitamin D3 receptor-interacting protein complex 80 kDa component antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse
  • 免疫原：
    Synthesized peptide derived from the Internal region of Human CRSP77.
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 抗体亚型：
    IgG
  • 纯化方式：
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 产品提供形式：
    Liquid
  • 应用范围：
    WB, IHC, ELISA
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:500-1:2000
    IHC 1:100-1:300
    ELISA 1:10000
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.
  • 基因功能参考文献：
    1. These findings suggest that hMED17 may play essential roles in switching between transcription and nucleotide excision repair. PMID: 25482373
    2. TRAP80 is a selective regulator of hepatic lipogenesis and is required for LXR-dependent SREBP-1c activation. PMID: 25437875
    3. Studies indicate that the activation domain of p53 (p53AD) binds directly to the MED17 subunit of Mediator, whereas the p53 C-terminal domain (p53CTD) binds the MED1 subunit. PMID: 21326907
    4. the p. L371P mutation in MED17 is a founder mutation in the Caucasus Jewish community and that homozygosity for this mutation is associated with infantile cerebral and cerebellar atrophy with poor myelination. PMID: 20950787
  • 相关疾病：
    Microcephaly, postnatal progressive, with seizures and brain atrophy (MCPHSBA)
  • 亚细胞定位：
    Nucleus.
  • 蛋白家族：
    Mediator complex subunit 17 family
  • 组织特异性：
    Ubiquitous.
  • 数据库链接：

    HGNC: 2375

    OMIM: 603810

    KEGG: hsa:9440

    STRING: 9606.ENSP00000251871

    UniGene: Hs.444931