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MED14 Antibody

  • 货号：
    CSB-PA063617
  • 规格：
    ￥1100
  • 图片：
    • The image on the left is immunohistochemistry of paraffin-embedded Human breast cancer tissue using CSB-PA063617(MED14 Antibody) at dilution 1/20, on the right is treated with synthetic peptide. (Original magnification: ×200)
  • 其他：

产品详情

  • Uniprot No.：
    O60244
  • 基因名：
    MED14
  • 别名：
    Activator-recruited cofactor 150 kDa component antibody; ARC150 antibody; Cofactor required for Sp1 transcriptional activation subunit 2 antibody; CRSP complex subunit 2 antibody; DRIP150 antibody; EXLM1 antibody; hRGR1 antibody; MED14 antibody; MED14_HUMAN antibody; Mediator complex subunit 14 antibody; Mediator of RNA polymerase II transcription subunit 14 antibody; RGR1 antibody; RGR1 homolog antibody; Thyroid hormone receptor-associated protein complex 170 kDa component antibody; Transcriptional coactivator CRSP150 antibody; Trap170 antibody; Vitamin D3 receptor-interacting protein complex 150 kDa component antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Synthetic peptide of Human MED14
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen affinity purification
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,IHC
  • 推荐稀释比：
    Application Recommended Dilution
    ELISA 1:2000-1:5000
    IHC 1:25-1:100
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.
  • 基因功能参考文献：
    1. Functional analysis implicates TNRC6A, NAT10, MED14, and WDR5 in RNA-mediated transcriptional activation. PMID: 28813667
    2. This results from a dramatically enhanced ability of MED14-containing complexes to associate with Pol II. PMID: 25383669
    3. VitD-mediated stimulation of GC anti-inflammatory affects human monocytes in a process involving GM-CSF and MED14 PMID: 23572530
    4. DRIP150 binds to ISGF3 and regulates transcription PMID: 12509459
    5. CRSP2 gene is expressed in the retina and its exact genomic location is on Xp11.4 between DXS1368 and DXS993 PMID: 12825353
    6. Coactivation of ERalpha by DRIP150 in ZR-75 cells is NR box-independent and requires a novel sequence with putative alpha-helical structure. PMID: 15625066
    7. MED14 and MED1 are used by glucocorticoid receptor in a gene-specific manner, providing a mechanism for promoter selectivity by glucocorticoid receptor PMID: 16239257
    8. Coactivator that enhances estrogen receptor alpha- and specificity protein (SP)-1-mediated transactivation in breast cancer cells. PMID: 17306756

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  • 亚细胞定位：
    Nucleus.
  • 蛋白家族：
    Mediator complex subunit 14 family
  • 组织特异性：
    Ubiquitous.
  • 数据库链接：

    HGNC: 2370

    OMIM: 300182

    KEGG: hsa:9282

    STRING: 9606.ENSP00000323720

    UniGene: Hs.407604