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MED13 Antibody

  • 货号：
    CSB-PA080113
  • 规格：
    ￥880
  • 其他：

产品详情

  • Uniprot No.：
    Q9UHV7
  • 基因名：
    MED13
  • 别名：
    MED13 antibody; ARC250 antibody; KIAA0593 antibody; THRAP1 antibody; TRAP240 antibody; Mediator of RNA polymerase II transcription subunit 13 antibody; Activator-recruited cofactor 250 kDa component antibody; ARC250 antibody; Mediator complex subunit 13 antibody; Thyroid hormone receptor-associated protein 1 antibody; Thyroid hormone receptor-associated protein complex 240 kDa component antibody; Trap240 antibody; Vitamin D3 receptor-interacting protein complex component DRIP250 antibody; DRIP250 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Synthesized peptide derived from the Internal region of Human TRAP240.
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 抗体亚型：
    IgG
  • 纯化方式：
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 产品提供形式：
    Liquid
  • 应用范围：
    IHC, ELISA
  • 推荐稀释比：
    Application Recommended Dilution
    IHC 1:100-1:300
    ELISA 1:40000
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.
  • 基因功能参考文献：
    1. Each of HSPA4 and MED13 mutations were detected in GC. PMID: 27129500
    2. Cardiac overexpression of MED13 in transgenic mice confers a lean phenotype that is associated with increased lipid uptake, beta-oxidation and mitochondrial content in white adipose tissue and liver PMID: 25422356
    3. Med12 and Med13 are critical for human CDK8 subcomplex -dependent repression, whereas CDK8 kinase activity is not PMID: 19240132
  • 亚细胞定位：
    Nucleus.
  • 蛋白家族：
    Mediator complex subunit 13 family
  • 组织特异性：
    Ubiquitous.
  • 数据库链接：

    HGNC: 22474

    OMIM: 603808

    KEGG: hsa:9969

    STRING: 9606.ENSP00000380888

    UniGene: Hs.282678