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ME2 Antibody

  • 货号：
    CSB-PA013633HA01HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Immunohistochemistry of paraffin-embedded human endometrial cancer using CSB-PA013633HA01HU at dilution of 1:100
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) ME2 Polyclonal antibody
  • Uniprot No.：
    P23368
  • 基因名：
    ME2
  • 别名：
    Malate dehydrogenase antibody; Malic enzyme 2 antibody; Malic enzyme 2 mitochondrial antibody; Malic enzyme 2 NAD(+) dependent mitochondrial antibody; Malic enzyme mitochondrial antibody; Malic enzyme NAD(+) dependent mitochondrial antibody; MAOM_HUMAN antibody; ME 2 antibody; ME2 antibody; mitochondrial antibody; NAD dependent malic enzyme mitochondrial antibody; NAD ME antibody; NAD-dependent malic enzyme antibody; NAD-ME antibody; ODS1 antibody; Pyruvic malic carboxylase antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Recombinant Human NAD-dependent malic enzyme, mitochondrial protein (296-424AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated

    本页面中的产品，ME2 Antibody (CSB-PA013633HA01HU)，的标记方式是Non-conjugated。对于ME2 Antibody，我们还提供其他标记。见下表：

    可提供标记
    标记方式 货号 产品名称 应用
    HRP CSB-PA013633HB01HU ME2 Antibody, HRP conjugated ELISA
    FITC CSB-PA013633HC01HU ME2 Antibody, FITC conjugated
    Biotin CSB-PA013633HD01HU ME2 Antibody, Biotin conjugated ELISA
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    >95%, Protein G purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, IHC
  • 推荐稀释比：
    Application Recommended Dilution
    IHC 1:20-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 基因功能参考文献：
    1. ME2 was involved in glioblastoma multiforme growth, invasion, migration, Reactive oxygen species and ATP production. PMID: 27166188
    2. deletion of malic enzyme 2 confers collateral lethality in pancreatic cancer PMID: 28099419
    3. Data indicate that malic enzyme 2 knockdown impacts phosphatidylinositol 3-kinases/proto-oncogene protein akt (PI3K/AKT) signaling. PMID: 24957098
    4. ME2 might be an important factor in melanoma progression and a novel biomarker of invasion. PMID: 25202825
    5. Three SNP alleles in BRD2, Cx-36, and ME2 and microdeletions in 15q13.3, 15q11.2, and 16p13.11 also contribute risk to juvenile myclonic epilepsy. PMID: 23756480
    6. Depletion of malic enzyme 2 induced erythroid differentiation in human erythroleukemia cells. PMID: 20824065
    7. An ME2-centered nine-SNP haplotype, when present homozygously, increases the risk for IGE (odds ratio 6.1; 95% confidence interval 2.9-12.7) compared with any other genotype PMID: 15532013
    8. Site directed mutagenesis was used to detrmine which amino acids in the active site of human mitochondrial NAD+-dependent malic enzyme are necessary for the inhibitory effects of ATP. PMID: 16171388
    9. These findings provide a molecular rationale for the role of hS14 in TR-dependent transcriptional activation of the expression of specific genes. PMID: 17418816
    10. Schizophrenic subjects are identified with mitochondrial genes involved in oxidative metabolism as showing consistently decreased expression, including ME2. PMID: 17638511
    11. Single nucleotide polymorphism in ME2 gene is associated with acute lymphoblastic leukemia. PMID: 19066393
    12. ME2 activity in Islets of Langerhans cells was measured by a spectrophotometric enzyme assay by utilizing the distinct kinetic properties. PMID: 19691144

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  • 亚细胞定位：
    Mitochondrion matrix.
  • 蛋白家族：
    Malic enzymes family
  • 数据库链接：

    HGNC: 6984

    OMIM: 154270

    KEGG: hsa:4200

    STRING: 9606.ENSP00000321070

    UniGene: Hs.233119