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ME1 Antibody

  • 货号：
    CSB-PA013632LA01HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Immunohistochemistry of paraffin-embedded human liver tissue using CSB-PA013632LA01HU at dilution of 1:100
    • Immunohistochemistry of paraffin-embedded human gastric cancer using CSB-PA013632LA01HU at dilution of 1:100
    • Immunofluorescent analysis of Hela cells using CSB-PA013632LA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) ME1 Polyclonal antibody
  • Uniprot No.：
    P48163
  • 基因名：
  • 别名：
    Cytosolic malic enzyme 1 antibody; HUMNDME antibody; Malate dehydrogenase antibody; Malic enzyme 1 antibody; Malic enzyme 1; NADP(+) dependent; cytosolic antibody; Malic enzyme 1; soluble antibody; Malic enzyme; cytoplasmic antibody; MAOX_HUMAN antibody; ME1 antibody; MES antibody; NADP dependent malic enzyme antibody; NADP ME antibody; NADP-dependent malic enzyme antibody; NADP-ME antibody; Pyruvic malic carboxylase antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Recombinant Human NADP-dependent malic enzyme protein (161-519AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated

    本页面中的产品，ME1 Antibody (CSB-PA013632LA01HU)，的标记方式是Non-conjugated。对于ME1 Antibody，我们还提供其他标记。见下表：

    可提供标记
    标记方式 货号 产品名称 应用
    HRP CSB-PA013632LB01HU ME1 Antibody, HRP conjugated ELISA
    FITC CSB-PA013632LC01HU ME1 Antibody, FITC conjugated
    Biotin CSB-PA013632LD01HU ME1 Antibody, Biotin conjugated ELISA
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    >95%, Protein G purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, IHC, IF
  • 推荐稀释比：
    Application Recommended Dilution
    IHC 1:20-1:200
    IF 1:50-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 基因功能参考文献：
    1. Bioinformatics analysis identified that miR612 targeted ME1, which expression was high and inversely associated with miR612 expression in bladder cancer tissues. PMID: 29620192
    2. Findings indicate that malic enzyme 1 (ME1) is a valid target for molecular therapy in oral squamous cell carcinomas (OSCCs). PMID: 29601126
    3. these findings uncover a direct cross-talk mechanism between ME1 and PPP, may reveal an alternative model for signaling transduction via protein conformational simulation, and pave the way for better understanding how metabolic pathways are coordinated in cancer. PMID: 28848047
    4. ME1/ME2 expression phenotype may have a potential to be a valuable marker for sebaceous differentiation in sebaceous lesions. PMID: 26381116
    5. ME1 expression was found to be mutant-KRAS-associated in NSCLC cancer cell lines. Patients with elevated ME1 had worse outcomes after radiotherapy. Transamination generating cytosolic NADPH via ME1 may contribute to radioresistance. PMID: 26173780
    6. ME1 overexpression associates with unfavorable prognoses in patients with HCC, suggesting that ME1 is a poor prognostic predictor of hepatocellular carcinoma. PMID: 25753478
    7. essential role for ME1 in the production of cytosolic NADPH and maintenance of migratory and invasive abilities of nasopharyngeal carcinoma cells PMID: 23114090
    8. the differential protein stability between dimer and tetramer interface interactions of human c-NADP-ME PMID: 23284632
    9. p53 represses the expression of the tricarboxylic-acid-cycle-associated malic enzymes ME1 and ME2 in human and mouse cells PMID: 23334421
    10. cytosolic malic enzyme 1 gene polymorphism is associated with the degree of suppression of parathyroid hormone after long-term calcium supplementation; the effect is probably mediated through an increase in intestinal calcium absorption PMID: 22456781
    11. ME1 is a functional target gene of the BACH1 transcription factor according to ChIP-seq and knockdown analysis in HEK 293 cells. PMID: 21555518
    12. that the single mutation of Gln362 to Lys in human m-NAD-ME changes it to an NADP+-dependent enzyme, which is characteristic because it is non-allosteric, non-cooperative, and NADP+-specific PMID: 16757477
    13. although ME1 overexpression augments anaplerosis and glucose stimulated insulin secretion in INS-1 832/13 cells, it is not likely involved in methyl succinate and glucose stimulated insulin secretion in pancreatic islets PMID: 19293334
    14. human c-NADP-ME exists mainly as a tetramer, whereas human m-NAD(P)-ME exists as a mixture of dimers and tetramers PMID: 19416979
    15. A series of R98/D102 mutants examined the possible interactions between Arg98 and Asp102 using double-mutant cycle analysis. Kinetic analysis revealed that the catalytic efficiency of was severely affected by mutating both Arg98 and Asp102 residues. PMID: 19464998

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  • 亚细胞定位：
    Cytoplasm.
  • 蛋白家族：
    Malic enzymes family
  • 组织特异性：
    Expressed in all tissues tested including liver, placenta and white adipose tissue.
  • 数据库链接：

    HGNC: 6983

    OMIM: 154250

    KEGG: hsa:4199

    STRING: 9606.ENSP00000358719

    UniGene: Hs.21160