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MDFI Antibody

  • 货号：
    CSB-PA003210
  • 规格：
    ￥880
  • 图片：
    • Western Blot analysis of Jurkat cells using MDFI Polyclonal Antibody
  • 其他：

产品详情

  • Uniprot No.：
    Q99750
  • 基因名：
    MDFI
  • 别名：
    MDFI antibody; MyoD family inhibitor antibody; Myogenic repressor I-mf antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse
  • 免疫原：
    Synthesized peptide derived from the Internal region of Human MDFI.
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 抗体亚型：
    IgG
  • 纯化方式：
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 产品提供形式：
    Liquid
  • 应用范围：
    WB, ELISA
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:500-1:2000
    ELISA 1:10000
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Inhibits the transactivation activity of the Myod family of myogenic factors and represses myogenesis. Acts by associating with Myod family members and retaining them in the cytoplasm by masking their nuclear localization signals. Can also interfere with the DNA-binding activity of Myod family members. Plays an important role in trophoblast and chondrogenic differentiation. Regulates the transcriptional activity of TCF7L1/TCF3 by interacting directly with TCF7L1/TCF3 and preventing it from binding DNA. Binds to the axin complex, resulting in an increase in the level of free beta-catenin. Affects axin regulation of the WNT and JNK signaling pathways.
  • 基因功能参考文献：
    1. MDFI was significantly hypermethylated in colorectal cancer tissues when compared with adjacent normal colorectal tissues. PMID: 28782576
    2. I-mfa domain proteins may be involved in their oncogenic functions by negatively regulating their transcriptional activities. PMID: 21664411
    3. I-mfa functions as a molecular switch to suppress the store dependence of TRPC1 PMID: 14530267
    4. These results suggest that the physical and functional interaction between Zic and I-mfa proteins can play a role in the vertebrate development. PMID: 15207726
  • 亚细胞定位：
    Nucleus. Cytoplasm.
  • 蛋白家族：
    MDFI family
  • 数据库链接：

    HGNC: 6967

    OMIM: 604971

    KEGG: hsa:4188

    STRING: 9606.ENSP00000230321

    UniGene: Hs.520119