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MCM5 Antibody

  • 货号：
    CSB-PA920054
  • 规格：
    ￥2024
  • 图片：
    • Immunohistochemical analysis of paraffin-embedded human tonsil tissue using MCM5 antibody.
    • Immunofluorescence analysis of HepG2 cells, using MCM5 antibody.
    • Western blot analysis of extracts from HepG2 cells, using MCM5 antibody.
    • Western blot analysis of extracts from HeLa cells (Lane 2), A549 cells (Lane 3) and cells (Lane 4), using MCM5 antiobdy. The lane on the left is treated with systhesized peptide.
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) MCM5 Polyclonal antibody
  • Uniprot No.：
    P33992
  • 基因名：
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse,Rat
  • 免疫原：
    Synthesized peptide derived from Human MCM5 antibody.
  • 免疫原种属：
    Homo sapiens (Human)
  • 克隆类型：
    Polyclonal
  • 纯化方式：
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,WB,IHC,IF
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:500-1:3000
    IHC 1:50-1:100
    IF 1:100-1:500
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Acts as component of the MCM2-7 complex (MCM complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity.
  • 基因功能参考文献：
    1. Minichromosome maintenance 5 was shown as an independent prognostic biomarker for patients with cervical cancer PMID: 29642758
    2. MCM5 expression is associated with the malignant status and poor prognosis in cervical adenocarcinoma patients. PMID: 29253764
    3. The RAS-related nuclear protein ((P) ran), breast cancer metastasis suppressor 1 ((P) brms1) and minichromosome maintenance complex component 5 ((P) mcm5) promoters have the specificity and strength needed for cancer-specific expression-targeted gene therapy. PMID: 27140445
    4. the incorporation of physiological levels of MCM5 into HIV-1 virions facilitates viral cDNA accumulation in newly infected cells, probably by modifying nucleic acid configuration during reverse transcription. PMID: 27414250
    5. MCM5 is a novel gene involved in Meier-Gorlin syndrome. PMID: 28198391
    6. Our findings support the hypothesis that MCM5 targeting may be regarded as an effective molecular therapy against anaplastic thyroid carcinoma PMID: 26911376
    7. we could consider miRNA-10b and MCM5 mRNA as prognostic markers and potential therapeutic targets in breast cancer to be applied to other patient data sets. PMID: 25596707
    8. The increased expression of MCM5 protein begins at the oral pre-cancerous stage and is significantly associated with the aggressive progression and poor prognosis of OSCC. PMID: 24245508
    9. Data indicate that MCM-BP binds USP7 on chromatin and can mediate an interaction between the USP7 and MCM proteins. PMID: 24190967
    10. The results of this study demonistrated that Mcm5 shows a highly significant correlation with Alcohol use disorders-induced decreases in the volume of the left parietal supramarginal gyrus and neuropsychological measures. PMID: 23095216
    11. MicroRNA miR-885-5p targets CDK2 and MCM5, activates p53 and inhibits proliferation and survival. PMID: 21233845
    12. lack of MCM5 proteins expression which may explain commonly known low mitotic activity of desmoid tumour cells PMID: 21478101
    13. MCM-5 expression was significantly associated with tumor size, presence of lymph node metastases and tumor histopathological stage. Patients with high MCM-5 expression had significantly shorter survival times. PMID: 20694513
    14. Could use the urinary hTERT, SENP1, PPP1CA, and MCM5 mRNA to detect bladder cancer recurrence. PMID: 21106093
    15. Results further confirm the importance of MCM5 in malignant transformation and in the pathogenesis of cervical dysplasia. PMID: 15696126
    16. The DNA replication factor MCM5 is essential for Stat1-mediated transcriptional activation. PMID: 16199513
    17. MCM5 is part of the GINS complex. PMID: 17557111
    18. results demonstrate pattern and frequency of MCM5 expression in various skin diseases PMID: 17988337
    19. Immunofluorescence technology to quantify cervical cell expression of two biomarkers p16(INK4A) and Mcm5 was developed and evaluated by both microscopy and flow cytometry. PMID: 18181189
    20. No significant association was observed between MCM-5 protein expression and the clinicopathological characteristics of colon cancer examined. PMID: 18465232
    21. Cyclin E is shown to directly interact with and colocalize on centrosomes with the DNA replication factor MCM5 in a centrosomal localization sequence-dependent but Cdk2-independent manner. PMID: 18799789
    22. Analysis of MCM5 expression in aggressive fibromatosis (desmoid tumor) is reported. PMID: 19130399

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  • 相关疾病：
    Meier-Gorlin syndrome 8 (MGORS8)
  • 亚细胞定位：
    Nucleus. Chromosome. Cytoplasm, cytosol.
  • 蛋白家族：
    MCM family
  • 数据库链接：

    HGNC: 6948

    OMIM: 602696

    KEGG: hsa:4174

    STRING: 9606.ENSP00000216122

    UniGene: Hs.517582