MBNL3 Antibody
产品详情
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产品名称:Rabbit anti-Homo sapiens (Human) MBNL3 Polyclonal antibody
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Uniprot No.:Q9NUK0
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基因名:MBNL3
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别名:A530038J18Rik antibody; AI661274 antibody; CHCR antibody; Cys3His CCG1 required protein antibody; Cys3His CCG1-required protein antibody; E430034C16Rik antibody; MBLX antibody; MBLX39 antibody; MBNL 3 antibody; Mbnl3 antibody; MBNL3_HUMAN antibody; MBXL antibody; Muscleblind like 3 antibody; Muscleblind like protein 3 antibody; Muscleblind like splicing regulator 3 antibody; Muscleblind like X linked protein antibody; Muscleblind-like protein 3 antibody; Muscleblind-like X-linked protein antibody; OTTMUSP00000019072 antibody; OTTMUSP00000019073 antibody; OTTMUSP00000019074 antibody; Protein HCHCR antibody; RP23-98P13.1 antibody
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宿主:Rabbit
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反应种属:Human
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免疫原:Recombinant Human Muscleblind-like protein 3 protein (116-211AA)
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免疫原种属:Homo sapiens (Human)
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标记方式:Non-conjugated
本页面中的产品,MBNL3 Antibody (CSB-PA868322LA01HU),的标记方式是Non-conjugated。对于MBNL3 Antibody,我们还提供其他标记。见下表:
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克隆类型:Polyclonal
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抗体亚型:IgG
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纯化方式:>95%, Protein G purified
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浓度:It differs from different batches. Please contact us to confirm it.
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保存缓冲液:Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 -
产品提供形式:Liquid
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应用范围:ELISA, IHC, IF
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推荐稀释比:
Application Recommended Dilution IHC 1:200-1:500 IF 1:50-1:200 -
Protocols:
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储存条件:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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货期:Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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靶点详情
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功能:Mediates pre-mRNA alternative splicing regulation. Acts either as activator or repressor of splicing on specific pre-mRNA targets. Inhibits cardiac troponin-T (TNNT2) pre-mRNA exon inclusion but induces insulin receptor (IR) pre-mRNA exon inclusion in muscle. Antagonizes the alternative splicing activity pattern of CELF proteins. May play a role in myotonic dystrophy pathophysiology (DM). Could inhibit terminal muscle differentiation, acting at approximately the time of myogenin induction.
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基因功能参考文献:
- The MBNL3 splicing factor promotes hepatocellular carcinoma by increasing pacillin expression through the alternative splicing of lncRNA-PXN-AS1. PMID: 28553938
- results suggest that CHCR is an inhibitor of myogenesis PMID: 12297108
- MBNL proteins promote opposite splicing patterns for cardiac troponin T and insulin receptor alternative exons PMID: 15257297
- We exclude MBNL3 as the causative gene in this family. PMID: 17102799
- MBNL3 was not found in human samples. PMID: 19095965
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亚细胞定位:Nucleus. Cytoplasm. Note=Greater concentration in the nucleus. In both DM1 and DM2 patients, colocalizes with nuclear foci of retained expanded-repeat transcripts.
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蛋白家族:Muscleblind family
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组织特异性:Highly expressed in the placenta.
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数据库链接:
HGNC: 20564
OMIM: 300413
KEGG: hsa:55796
STRING: 9606.ENSP00000359890
UniGene: Hs.105134