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MBD4 Antibody

  • 货号：
    CSB-PA013535GA01HU
  • 规格：
    ￥3,900
  • 其他：

产品详情

  • Uniprot No.：
    O95243
  • 基因名：
  • 别名：
    3 N(4) ethenocytosine glycosylase antibody; G/5 fluorouracil mismatch glycosylase with biphasic kinetics antibody; G/T mismatch glycosylase antibody; G/U mismatch glycosylase antibody; MBD 4 antibody; MBD4 antibody; MBD4_HUMAN antibody; MED 1 antibody; MED1 antibody; Methyl CpG binding domain protein 4 antibody; Methyl CpG binding endonuclease 1 antibody; Methyl CpG binding protein MBD4 antibody; Methyl-CpG-binding domain protein 4 antibody; Methyl-CpG-binding endonuclease 1 antibody; Methyl-CpG-binding protein MBD4 antibody; Mismatch specific DNA N glycosylase antibody; Mismatch-specific DNA N-glycosylase antibody; Putative methyl CpG binding protein antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse
  • 免疫原：
    Human MBD4
  • 免疫原种属：
    Homo sapiens (Human)
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen Affinity purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,WB
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Mismatch-specific DNA N-glycosylase involved in DNA repair. Has thymine glycosylase activity and is specific for G:T mismatches within methylated and unmethylated CpG sites. Can also remove uracil or 5-fluorouracil in G:U mismatches. Has no lyase activity. Was first identified as methyl-CpG-binding protein.
  • 基因功能参考文献：
    1. Results demonstrated that MBD4 was downregulated, which lead to the overexpression and promoter hypomethylation of CD70 in CD4+ T cells from patients from systemic lupus erythematosus (SLE). This study preliminarily revealed the role and mechanism of MBD4 in the pathogenesis of SLE. PMID: 29018507
    2. these data suggest that MBD4 inactivation may contribute to tumorigenesis, acting as a modifier of mismatch repair-deficient cancer phenotype. PMID: 26503472
    3. MBD4 rs3138373 A>G and rs2005618 T>C single nucleotide polymorphisms were not associated with esophageal squamous cell carcinoma (ESCC) risk. rs3138355 GG genotype was associated with a decreased risk of ESCC among male patients and the elderly. PMID: 25162968
    4. Interaction between DNMT1 and MBD4 is involved in controlling gene expression and responding to oxidative stress. PMID: 24434851
    5. ERCC4 rs1800124 and MBD4 rs10342 non-synonymous single nucleotide polymorphism variants were associated with DNA repair capacity. PMID: 24004570
    6. the crystal structure of MBD4 bound to 5-hydroxymethylcytosine further demonstrates that MBDMBD4 is able to recognize a wide range of 5-methylcytosine modifications PMID: 23316048
    7. MBD4 Glu346Lys polymorphism is associated with the risk of cervical cancer in a Chinese population. PMID: 23027038
    8. Crystal structures of human MBD4(catalytic domain) reveal that MBD4 uses a base flipping mechanism to specifically recognize thymine and 5-hydroxymethyluracil. PMID: 22848106
    9. specificity of MBD4 for acting at CpG sites depends largely on its methyl-CpG-binding domain, which binds preferably to G.T mispairs in a methylated CpG site PMID: 22560993
    10. MBD4-8666 and MBD4-9229, but not MBD4-1057, gene polymorphisms are related to rheumatoid arthritis in Chinese patients in Taiwan. PMID: 20676650
    11. MBD 4--a potential substrate for protein kinase X PMID: 21971312
    12. the crystal structure of C-terminal glycosylase domain of human MBD4 was determined. PMID: 21820404
    13. decreased expression in patients with primary immune thrombocytopenia PMID: 21377502
    14. Data suggest that methyl-CpG binding domain 4 polymorphism may not be a stratification marker to predict the susceptibility to immune thrombocytopenic purpura, at least in the Chinese population. PMID: 20100009
    15. MBD4 expression is associated with grade of malignancy in gliomas PMID: 11836615
    16. results indicate the formation of a complex with the estradiol receptor PMID: 12220634
    17. Frameshift mutations were found in 29% of gastric and 20% of colon MSI-H cancers, but not in any low-frequency microsatellite instability/microsatellite stable cancers. PMID: 12430186
    18. MBD4 mutations were found in 15% MSI but not in MSS colrectal tumors. PMID: 12926109
    19. MBD4 acts as a repressor protein binding to hypermethylated promoters of the p16(INK4a) and hMLH1 genes. PMID: 15899845
    20. MBD4 Glu346Lys polymorphism could be used as a marker for genetic susceptibility to adenocarcinoma of the lung. PMID: 16803845
    21. Mutations in MBD4 are unlikely to be implicated in HPS. PMID: 16831587
    22. These results suggest that RFP is a mediator connecting several MBD proteins and allowing the formation of a more potent transcriptional repressor complex. PMID: 17049487
    23. The overexpression of MBD4(tru) in Big Blue (lacI)-transfected, MSI human colorectal carcinoma cells doubled mutation frequency, indicating that the modest dominant negative effect on DNA repair can occur in living cells in short-term experiments. PMID: 17285135
    24. MBD2 and MBD4 transcript overexpression and inverse correlations with DNA methylation indices indicate that both enzymes may really have a direct and active role on the genome-wide DNA hypomethylation observed in CD4+ T cells from SLE patients. PMID: 17360956
    25. Truncation of MBD4 predisposes to reciprocal chromosomal translocations and alters the response to therapeutic agents in colon cancer cells. PMID: 18162445
    26. Single nucleotide polymorphisms in MBD4 are associated with lung cancer. PMID: 18495292
    27. MBD4 efficiently processed T/G mismatches within the nucleosome. PMID: 18519584
    28. The methyl binding domain of MBD4/MED1 was found to specifically inhibit the activity of MBD4/MED1 as well as the glycosylase domain, when the G:IU mispairs were located in a methylated CpG context. PMID: 19395862
    29. The Glu346Lys polymorphism and frameshift mutations of the Methyl-CpG Binding Domain 4 gene is associated with gastrointestinal cancer PMID: 19469655

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  • 亚细胞定位：
    Nucleus.
  • 数据库链接：

    HGNC: 6919

    OMIM: 603574

    KEGG: hsa:8930

    STRING: 9606.ENSP00000249910

    UniGene: Hs.35947