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MB Antibody

  • 货号：
    CSB-PA212278
  • 规格：
    ￥1100
  • 图片：
    • The image on the left is immunohistochemistry of paraffin-embedded Human colon cancer tissue using CSB-PA212278(MB Antibody) at dilution 1/25, on the right is treated with fusion protein. (Original magnification: ×200)
    • The image on the left is immunohistochemistry of paraffin-embedded Human liver cancer tissue using CSB-PA212278(MB Antibody) at dilution 1/25, on the right is treated with fusion protein. (Original magnification: ×200)
    • Gel: 10%SDS-PAGE, Lysate: 40 μg, Lane 1-2: Mouse heart tissue, Mouse muscle tissue, Primary antibody: CSB-PA212278(MB Antibody) at dilution 1/350, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 20 seconds
  • 其他：

产品详情

  • Uniprot No.：
    P02144
  • 基因名：
    MB
  • 别名：
    MB antibody; MGC13548 antibody; MYG_HUMAN antibody; Myoglobin antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse,Rat
  • 免疫原：
    Fusion protein of Human MB
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen affinity purification
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,WB,IHC
  • 推荐稀释比：
    Application Recommended Dilution
    ELISA 1:2000-1:5000
    WB 1:500-1:2000
    IHC 1:50-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Serves as a reserve supply of oxygen and facilitates the movement of oxygen within muscles.
  • 基因功能参考文献：
    1. The results showed that the MI-based bio-sensing system had high selectivity and sensitivity for detection of Cardiac biomarkers . Compared with the control region, ultrasensitive detections of CRP and Mb were accomplished with the detection limits of 1.0 pg/mL and 0.1 pg/mL, respectively. PMID: 29857573
    2. Report morphology of myoglobin casts in renal biopsies with acute kidney injury. PMID: 27038680
    3. Myoglobin is associated with larger hematoma volume and growth after adjusting potential confounding factors in intracerebral hemorrhage. PMID: 27056440
    4. we found that the A79G polymorphism of the MB gene plays an important role in influencing the development of exercise-induced skeletal muscle damage. PMID: 27323063
    5. Electroanalysis of myoglobin as a marker of acute myocardial infarction by means of screenprinted electrodes modified with multiwalled carbon nanotubes and polymeric artificial antibodies is developed. Plastic antibodies to myoglobin (molecularly imprinted polymers, MIPs) based on o-phenylenediamine were produced by electropolymerization. Molecular imprinting technology in biosensor analysis was used. PMID: 27417724
    6. In the absence of Mb, the Y-shape structure remains intact. So, a weak electrochemical signal is observed. Upon addition of target, the DApt leave the CS and bind to Mb, leading to disassembly of Y-shape structure and following the addition of Exo I, a strong electrochemical signal could be recorded. PMID: 26894983
    7. analysis of myoglobin gene regulatory networks in breast and prostate cancer PMID: 26559958
    8. Data show that with the myoglobin (MYO) monoclonal antibody of high specificity and affinity, a one-step sandwich ELISA for detecting MYO has been established successfully, which provides a basis for the development of domestic ELISA kit. PMID: 26271987
    9. Misfolding and amyloid aggregation of apomyoglobin. PMID: 23839096
    10. A non-ischemic serum myoglobin release is rare, but could be associated in subgroups of patients. PMID: 25002394
    11. Data show that chimeric neuroglobin and myoglobin were generated by swapping a regulatory segment. PMID: 25452214
    12. Findings indicate that myoglobin (Mb) and neuroglobin (Ngb) can be expressed in nonmuscle and non-neural contexts. PMID: 24446190
    13. Analogous to breast cancer, MB expression in prostate cancer is associated with steroid hormone signaling and markers of hypoxia PMID: 25172328
    14. the novel cancer-associated MB splice variants exhibited increased expression in tumor cells subjected to experimental hypoxia; the novel gene regulatory mechanisms unveiled in this study support the idea of a non-canonical role of MB during carcinogenesis PMID: 24026678
    15. Blood myoglobin could serve as a valuable early predictor and marker of rhabdomyolysis and acute myoglobinuric kidney injury PMID: 23931877
    16. High myoglobin expression is associated with renal cell carcinoma. PMID: 24076247
    17. Our LFIA performance was additionally compared with electrochemiluminescence immunoassay (ECLI) detection for simultaneous determination of hs-cTnI and myoglobin in patients with suggestive of acute myocardial infarction . PMID: 23247055
    18. Hydrophobic effect drives oxygen uptake in myoglobin via histidine E7. PMID: 23297402
    19. MD simulations supported NMR results indicating interesting structural/dynamical differences in the average volume and occurrence of the main cavities lining Mb prosthetic group. PMID: 21782983
    20. The mitochondrion-impairing role of MB in hypoxic cancer cells is part of a novel tumor-suppressive function. PMID: 21930697
    21. overexpression in non-small cell lung cancer is associated with histological subtype and hypoxia PMID: 21601304
    22. may have potential significance in the prognostication of lung adenocarcinomas PMID: 21640426
    23. Apomyoglobin mutants with point mutations at val10 forms amyloid structures at permissive temperature. PMID: 21639835
    24. These results show that glutathione reduces hydrogen peroxide-induced protein decomposition due to reduction of the C110-thiyl radical in WTwild type human Mb by electron transfer. PMID: 21256983
    25. Water entry into the heme pockets of isolated hemoglobin subunits was detected by optical methods. PMID: 20668762
    26. Kinetics of interaction between apomyoglobin and phospholipid membrane PMID: 20873231
    27. Using a cardiovascular model suggest that myoglobin oxygen storage/transport becomes significant during systolic reduction of coronary blood flow rather than during diastole. PMID: 20124401
    28. 71% of tumours displayed Mb protein expression in significant correlation with a positive hormone receptor status and better prognosis. PMID: 20531416
    29. The Dimension Vista cTnI, CK-MB, MYO, NTproBNP, and hsCRP methods demonstrate acceptable performance characteristics for use as an aid in the diagnosis and risk assessment of patients presenting with suspected acute coronary syndromes. PMID: 19523464
    30. Screening of exon 2 of the myoglobin gene in high altitude Tibetans does not show novel polymorphism or selection for specific myoglobin alleles as a function of altitude of residence or hypoxic challenge. PMID: 12006163
    31. myoglobin/carbonic anhydrase III ratio in the blood proved to be a more specific indicator for myocardial damage than myoglobin alone after myocardial infarction. PMID: 12745799
    32. It was concluded that myoglobin levels on admission and TnT at 2 h had the greatest diagnostic rate for myocardial infarction. PMID: 12760310
    33. Oxidative stress associated with myoglobin expression specifically in mitochondrial diseases. PMID: 14506721
    34. determination of myoglobin concentration and succinate dehydrogenase activity in serial sections indicate that myoglobin can lead to a substantial reduction (18-60%) of the extracellular oxygen tension required to prevent an anoxic core in muscle cells PMID: 15048578
    35. Quantitative test is useful for early diagnosis of acute myocardial infarct and as an indicator of its severity. PMID: 15226628
    36. Binding to blood fatty acid binding protein and may be a marker for cardiac damage in hemodialysis patients. PMID: 15226631
    37. heme rotates about the alpha-gamma axis of human myoglobin without leaving the protein cage PMID: 15485667
    38. energy analysis of myoglobin recognition of oxygen PMID: 15601759
    39. S-nitroso oxymyoglobin stores vasoactive nitric oxide PMID: 15644316
    40. iron mobilization and myoglobin down-modulation are elicited by enhanced erythropoiesis from elevated iron PMID: 17311997
    41. Data show plasma MG may be considered as a novel marker of muscle mass indicating best the mass of MG-rich type 1 and 2a fibers as well as VO(2)max as an important functional readout. PMID: 17605115
    42. analysis of covalent modification, unfolding, and aggregation of human holo-myoglobin induced by tyrosinase-generated quinones PMID: 17883274
    43. In this study, we showed for the first time the connection of ROR2 in Dupuytren's disease. ROR2 and myoglobin may play an important role in the pathophysiology of this disease PMID: 17996904
    44. Hypoxia reprograms calcium signaling and regulates myoglobin expression. PMID: 19005161
    45. myoglobin is expressed at high levels by human carcinoma cells PMID: 19541931
    46. Exposure of vascular smooth muscle (either in cell culture or intact vessels) to pathological nitric oxide (*NO) promotes an up-regulation of the Mb gene and protein, suggesting a feedback relationship between *NO and Mb. PMID: 19650765

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  • 蛋白家族：
    Globin family
  • 数据库链接：

    HGNC: 6915

    OMIM: 160000

    KEGG: hsa:4151

    STRING: 9606.ENSP00000352835

    UniGene: Hs.517586