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MARS Antibody

  • 中文名称：
    MARS兔多克隆抗体
  • 货号：
    CSB-PA013500GA01HU
  • 规格：
    ￥3,900
  • 其他：

产品详情

  • Uniprot No.：
    P56192
  • 基因名：
    MARS
  • 别名：
    cytoplasmic antibody; FLJ35667 antibody; Mars antibody; Methionine tRNA ligase 1 antibody; Methionine tRNA ligase 1 cytoplasmic antibody; Methionine tRNA ligase antibody; Methionine tRNA synthetase antibody; Methionine--tRNA ligase antibody; Methionyl tRNA synthetase cytoplasmic antibody; Methionyl-tRNA synthetase antibody; MetRS antibody; MRS antibody; MTRNS antibody; SYMC_HUMAN antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse,Rat
  • 免疫原：
    Human MARS
  • 免疫原种属：
    Homo sapiens (Human)
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen Affinity purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,WB
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Catalyzes the specific attachment of an amino acid to its cognate tRNA in a 2 step reaction: the amino acid (AA) is first activated by ATP to form AA-AMP and then transferred to the acceptor end of the tRNA. Plays a role in the synthesis of ribosomal RNA in the nucleolus.
  • 基因功能参考文献：
    1. Compound Arg618Cys and Tyr307Cys variants were identified in an infant with syndromic interstitial lung and liver disease. Arg618Cys associated with Charcot-Marie-Tooth disease was inherited from an unaffected father. PMID: 29655802
    2. MRS is frequently overexpressed in NSCLC. Moreover, MRS is related to mTORC1 activity and its overexpression is associated with poor clinical outcomes, indicating that it has potential as a putative therapeutic target. PMID: 28679377
    3. Genotype-phenotype correlation analysis suggests most of the interstitial lung and liver disease (ILLD), mutations locate in the catalytic domain of MARS. ILLD and Charcot-Marie-Tooth disease, axonal, type 2U might have different disease mechanism. PMID: 28148924
    4. analysis of the heterotetrameric complex structure of the glutathione transferase (GST) domains shared among the four MSC components, methionyl-tRNA synthetase (MRS), glutaminyl-prolyl-tRNA synthetase (EPRS), AIMP2 and AIMP3 PMID: 26472928
    5. identification of a founder mutation in MARS led to the molecular definition of a specific type of pulmonary alveolar proteinosis and will enable carrier screening in the affected community and possibly open new treatment opportunities. PMID: 25913036
    6. the association of rare MARS variant with late-onset autosomal dominant Charcot-Marie-Tooth neuropathy PMID: 24354524
    7. The F370L and I523T mutations did not affect the association of MARS with the multisynthetase complex. PMID: 24103465
    8. Here we present data suggesting that MARS is a very rare novel cause of late-onset CMT2. PMID: 23729695
    9. Data show that aminoacyl-tRNA synthetase-interacting multifunctional protein-3 (AIMP3)/p18 is released from aminoacyl-tRNA synthetase-interacting multifunctional protein-3 (AIMP3) by UV irradiation-induced stress. PMID: 22106287
    10. The last 15 residues of the previously defined N-terminal extension of hcMetRS are part of the catalytic domain, whereas the first 252 residues constitute the N-terminal extended domain. PMID: 19064003

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  • 相关疾病：
    Interstitial lung and liver disease (ILLD); Charcot-Marie-Tooth disease 2U (CMT2U)
  • 亚细胞定位：
    Cytoplasm, cytosol. Nucleus, nucleolus.
  • 蛋白家族：
    Class-I aminoacyl-tRNA synthetase family
  • 数据库链接：

    HGNC: 6898

    OMIM: 156560

    KEGG: hsa:4141

    STRING: 9606.ENSP00000262027

    UniGene: Hs.632707