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  4. MARK4 Antibody

MARK4 Antibody

  • 货号：
    CSB-PA219664
  • 规格：
    ￥1100
  • 图片：
    • The image on the left is immunohistochemistry of paraffin-embedded Human gastic cancer tissue using CSB-PA219664(MARK4 Antibody) at dilution 1/20, on the right is treated with synthetic peptide. (Original magnification: ×200)
  • 其他：

产品详情

  • Uniprot No.：
    Q96L34
  • 基因名：
    MARK4
  • 别名：
    FLJ90097 antibody; KIAA1860 antibody; MAP / microtubule affinity regulating kinase 4 antibody; MAP / microtubule affinity regulating kinase 4L antibody; MAP/microtubule affinity regulating kinase 4 antibody; MAP/microtubule affinity regulating kinase like 1 antibody; MAP/microtubule affinity-regulating kinase 4 antibody; MAP/microtubule affinity-regulating kinase-like 1 antibody; MARK 4 antibody; MARK 4L antibody; MARK L1 antibody; MARK4 antibody; MARK4 serine / threonine protein kinase antibody; MARK4 serine/threonine protein kinase antibody; MARK4_HUMAN antibody; MARK4S antibody; MARKL 1 antibody; MARKL1 antibody; Nbla00650 antibody; Putative protein product of Nbla00650 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse
  • 免疫原：
    Synthetic peptide of Human MARK4
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen affinity purification
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,IHC
  • 推荐稀释比：
    Application Recommended Dilution
    ELISA 1:1000-1:2000
    IHC 1:25-1:100
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Serine/threonine-protein kinase. Phosphorylates the microtubule-associated protein MAPT/TAU. Also phosphorylates the microtubule-associated proteins MAP2 and MAP4. Involved in regulation of the microtubule network, causing reorganization of microtubules into bundles. Required for the initiation of axoneme extension during cilium assembly. Regulates the centrosomal location of ODF2 and phosphorylates ODF2 in vitro. Plays a role in cell cycle progression, specifically in the G1/S checkpoint. Reduces neuronal cell survival. Plays a role in energy homeostasis by regulating satiety and metabolic rate. Promotes adipogenesis by activating JNK1 and inhibiting the p38MAPK pathway, and triggers apoptosis by activating the JNK1 pathway. Phosphorylates mTORC1 complex member RPTOR and acts as a negative regulator of the mTORC1 complex, probably due to disruption of the interaction between phosphorylated RPTOR and the RRAGA/RRAGC heterodimer which is required for mTORC1 activation.
  • 基因功能参考文献：
    1. data demonstrate that miR-515-5p dramatically inhibits cell migration by directly down-regulating MARK4 expression in two different cancer types PMID: 26882547
    2. Our results show that MARK4 acts as a negative regulator of the Hippo kinase cassette to promote YAP/TAZ activity and that loss of MARK4 restrains the tumorigenic properties of breast cancer cells. PMID: 28183853
    3. Atypical PKC phosphorylates serine-threonine residues of MARK4. PMID: 26346160
    4. Suggest role for polypyrimidine-tract binding protein in regulating alternative splicing of MARK4 in gliomas. PMID: 25578778
    5. MARK4 is a key component in the regulation of microtubule dynamics and has major role in cell cycle progression, particularly at the G1/S transition. PMID: 25123532
    6. Molecular dynamic simulation data predicted the three dimensional structure for the kinase domain of MARK4 and its structural properties. PMID: 24763618
    7. A strong and significant elevation of MARK4 expression and MARK4-tau interactions in AD brains correlates with the Braak stages of the disease, suggesting that the MARK4-tau interactions are of functional importance in the progression of AD. PMID: 23666762
    8. MARK4 is a critical positive regulator of early steps in ciliogenesis. PMID: 23400999
    9. MARK4 is a new negative regulator of mTORC1 PMID: 23184942
    10. The balance between the MARK4 isoforms is carefully guarded during neural differentiation but may be subverted in gliomagenesis. PMID: 22156016
    11. Even though an association of the polymorphisms rs2850328 and rs2395 and breast cancer was not detected in our case-control study population, other variants within the PPP3CA and MARK4 genes may still be associated with breast cancer. PMID: 22506312
    12. Observational study, meta-analysis, and genome-wide association study of gene-disease association and gene-gene interaction. (HuGE Navigator) PMID: 20460622
    13. demonstrated that the endogenous MARK4L colocalizes with centrosomes at all mitotic stages and resides in centrosome-enriched fractions. PMID: 19759416
    14. Normally expressed in neural progenitors, re-expressed in gliomas and may become a target of amplification upon chr. 19 rearrangement. PMID: 12735302
    15. MARK4 is likely to be directly involved in microtubule organization in neuronal cells PMID: 14594945
    16. NUAK1 and MARK4 are substrates of USP9X PMID: 18254724

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  • 亚细胞定位：
    Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, microtubule organizing center. Cytoplasm, cytoskeleton, cilium basal body. Cytoplasm, cytoskeleton, cilium axoneme. Cytoplasm. Cell projection, dendrite.
  • 蛋白家族：
    Protein kinase superfamily, CAMK Ser/Thr protein kinase family, SNF1 subfamily
  • 组织特异性：
    Ubiquitous. Isoform 2 is brain-specific. Expressed at highest levels in brain and testis. Also expressed in heart, lung, liver, muscle, kidney and spleen.
  • 数据库链接：

    HGNC: 13538

    OMIM: 606495

    KEGG: hsa:57787

    STRING: 9606.ENSP00000262891

    UniGene: Hs.34314