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  4. MAPRE3 Antibody

MAPRE3 Antibody

  • 货号：
    CSB-PA571087
  • 规格：
    ￥1100
  • 图片：
    • The image on the left is immunohistochemistry of paraffin-embedded Human brain tissue using CSB-PA571087(ECE1 Antibody) at dilution 1/50, on the right is treated with fusion protein. (Original magnification: ×200)
    • The image on the left is immunohistochemistry of paraffin-embedded Human liver cancer tissue using CSB-PA571087(ECE1 Antibody) at dilution 1/50, on the right is treated with fusion protein. (Original magnification: ×200)
    • Gel: 6%SDS-PAGE, Lysate: 40 μg, Lane 1-2: Mouse lung tissue, Mouse liver tissue, Primary antibody: CSB-PA571087(ECE1 Antibody) at dilution 1/1050, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 10 seconds
  • 其他：

产品详情

  • Uniprot No.：
    Q9UPY8
  • 基因名：
    MAPRE3
  • 别名：
    APC binding protein antibody; EB 3 antibody; EB1 protein family member 3 antibody; EB3 antibody; EBF 3 antibody; EBF-3 antibody; EBF3 antibody; EBF3 S antibody; End binding protein 3 antibody; End-binding protein 3 antibody; MAPRE 3 antibody; MAPRE3 antibody; MARE3_HUMAN antibody; Member 3 antibody; Microtubule Associated Protein antibody; Microtubule associated protein RP/EB family member 3 antibody; Microtubule-associated protein RP/EB family member 3 antibody; OTTHUMP00000200910 antibody; RP 3 antibody; RP/EB Family antibody; RP3 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse
  • 免疫原：
    Fusion protein of Human ECE1
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen affinity purification
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,WB,IHC
  • 推荐稀释比：
    Application Recommended Dilution
    ELISA 1:2000-1:10000
    WB 1:1000-1:5000
    IHC 1:50-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Plus-end tracking protein (+TIP) that binds to the plus-end of microtubules and regulates the dynamics of the microtubule cytoskeleton. Promotes microtubule growth. May be involved in spindle function by stabilizing microtubules and anchoring them at centrosomes. Also acts as a regulator of minus-end microtubule organization: interacts with the complex formed by AKAP9 and PDE4DIP, leading to recruit CAMSAP2 to the Golgi apparatus, thereby tethering non-centrosomal minus-end microtubules to the Golgi, an important step for polarized cell movement. Promotes elongation of CAMSAP2-decorated microtubule stretches on the minus-end of microtubules. May play a role in cell migration.
  • 基因功能参考文献：
    1. One candidate pathway coupling actin filaments to microtubules consists of the actin filament-binding protein drebrin and the microtubule-binding +TIP protein EB3. This pathway is regulated proximally by cyclin-dependent kinase 5 phosphorylation of drebrin but the upstream elements in the pathway have yet to be identified. PMID: 28865014
    2. Findings show that co-ordination of dynamic microtubules and actin filaments by the drebrin/EB3 pathway drives prostate cancer cell invasion and is therefore implicated in disease progression. PMID: 28319065
    3. Findings suggest that methylation-associated down-regulation of EBF3 and IRX1 genes may play an important role in a pathogenic effect of TGF-beta on RASFs. PMID: 23456299
    4. Daughter cell adhesion and cytokinesis completion are spatially regulated by distinct states of EB3 phosphorylation on serine 176 by Aurora B. PMID: 23712260
    5. decreasing the drebrin E levels disrupted the normal subapical F-actin-myosin-IIB-betaII-spectrin network and the apical accumulation of EB3, a microtubule-plus-end-binding protein PMID: 22275434
    6. VE-cadherin outside-in signaling regulates cytosolic calcium homeostasis and EB3 phosphorylation. PMID: 23159740
    7. study found a polycytosine repeat (C8) in exon 5 of MAPRE3 that could be a potential mutation target in cancers with microsatellite instability (MSI); found that the C8 is frequently mutated in gastric and colorectal carcinomas with MSI PMID: 20632835
    8. The RP3 protein is involved in SATB1-mediated gene repression of Bcl2 and dynein subunit rp3 has functions independent of the dynein motor. PMID: 16079286
    9. Data show that two mitotic kinases, Aurora-A and Aurora-B, phosphorylate endogenous EB3 at Ser-176, and the phosphorylation triggers disruption of the EB3-SIAH-1 complex, resulting in EB3 stabilization during mitosis. PMID: 19696028

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  • 亚细胞定位：
    Cytoplasm, cytoskeleton.
  • 蛋白家族：
    MAPRE family
  • 组织特异性：
    Predominantly expressed in brain and muscle.
  • 数据库链接：

    HGNC: 6892

    OMIM: 605788

    KEGG: hsa:22924

    STRING: 9606.ENSP00000233121

    UniGene: Hs.515860