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MAPK8IP2 Antibody

  • 货号：
    CSB-PA008389
  • 规格：
    ￥880
  • 其他：

产品详情

  • Uniprot No.：
    Q13387
  • 基因名：
  • 别名：
    C jun amino terminal kinase interacting protein 2 antibody; C-jun-amino-terminal kinase-interacting protein 2 antibody; Homologous to mouse JIP 1 antibody; IB 2 antibody; IB-2 antibody; IB2 antibody; Islet brain 2 antibody; Islet-brain-2 antibody; JIP 2 antibody; JIP-2 antibody; JIP2 antibody; JIP2_HUMAN antibody; JNK interacting protein 2 antibody; JNK MAP kinase scaffold protein 2 antibody; JNK MAP kinase scaffold protein JIP2 antibody; JNK-interacting protein 2 antibody; MAPK8IP2 antibody; Mitogen activated protein kinase 8 interacting protein 2 antibody; Mitogen-activated protein kinase 8-interacting protein 2 antibody; PRKM8 interacting protein like antibody; PRKM8IPL antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse,Rat
  • 免疫原：
    Synthesized peptide derived from the C-terminal region of Human JIP-2.
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 抗体亚型：
    IgG
  • 纯化方式：
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 产品提供形式：
    Liquid
  • 应用范围：
    WB, IHC, IF, ELISA
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:500-1:2000
    IHC 1:100-1:300
    IF 1:200-1:1000
    ELISA 1:20000
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    The JNK-interacting protein (JIP) group of scaffold proteins selectively mediates JNK signaling by aggregating specific components of the MAPK cascade to form a functional JNK signaling module. JIP2 inhibits IL1 beta-induced apoptosis in insulin-secreting cells. May function as a regulator of vesicle transport, through interactions with the JNK-signaling components and motor proteins.
  • 基因功能参考文献：
    1. Human IB2 mutation has a role as a contributing genetic factor in chromosome 22-associated cognitive disorders. PMID: 21048139
    2. there is a signaling module in which IB2 scaffolds a MLK3/MKK/p38delta kinase cascade. PMID: 12244047
  • 亚细胞定位：
    Cytoplasm.
  • 蛋白家族：
    JIP scaffold family
  • 组织特异性：
    Expressed mainly in the brain and pancreas, including insulin-secreting cells. In the nervous system, more abundantly expressed in the cerebellum, pituitary gland, occipital lobe and the amygdala. Also expressed in fetal brain. Very low levels found in ut
  • 数据库链接：

    HGNC: 6883

    OMIM: 607755

    KEGG: hsa:23542

    STRING: 9606.ENSP00000330572

    UniGene: Hs.558180