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MAP3K21 Antibody

  • 货号：
    CSB-PA719421LA01HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Western Blot
      Positive WB detected in: 293T whole cell lysate, HepG2 whole cell lysate, Hela whole cell lysate
      All lanes: MAP3K21 antibody at 3.3µg/ml
      Secondary
      Goat polyclonal to rabbit IgG at 1/50000 dilution
      Predicted band size: 114, 64, 53 kDa
      Observed band size: 114 kDa
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) MAP3K21 Polyclonal antibody
  • Uniprot No.：
    Q5TCX8
  • 基因名：
    MAP3K21
  • 别名：
    dJ862P8.3 antibody; KIAA1804 antibody; M3KL4_HUMAN antibody; Mitogen activated protein kinase kinase kinase antibody; Mitogen-activated protein kinase kinase kinase MLK4 antibody; Mixed lineage kinase 4 antibody; MLK 4 antibody; Mlk4 antibody; RP5 862P8.2 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Recombinant Human Mitogen-activated protein kinase kinase kinase 21 protein (640-794AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated

    本页面中的产品，MAP3K21 Antibody (CSB-PA719421LA01HU)，的标记方式是Non-conjugated。对于MAP3K21 Antibody，我们还提供其他标记。见下表：

    可提供标记
    标记方式 货号 产品名称 应用
    HRP CSB-PA719421LB01HU MAP3K21 Antibody, HRP conjugated ELISA
    FITC CSB-PA719421LC01HU MAP3K21 Antibody, FITC conjugated
    Biotin CSB-PA719421LD01HU MAP3K21 Antibody, Biotin conjugated ELISA
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    >95%, Protein G purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, WB
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:500-1:5000
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Negative regulator of TLR4 signaling. Does not activate JNK1/MAPK8 pathway, p38/MAPK14, nor ERK2/MAPK1 pathways.
  • 基因功能参考文献：
    1. These results suggest that in the early response to stressful stimuli, MLK4beta-MLK3 binding is important for regulating MLK3 activity and MAPK signalling, and after prolonged periods of stress exposure, MLK4beta and MLK3 proteins decline via CHIP-dependent degradation. PMID: 28757353
    2. results uncover MLK4 as an upstream regulator of NF-kappaB signaling and a potential molecular target for the MES subtype of glioblastomas PMID: 26859459
    3. In establishing the role of MLK4 in intracellular signaling, we show it directly phosphorylates MEK1 (MAP2K1) and that MEK/ERK (MAPK1) signaling is impaired in MLK4 knockout cells PMID: 23319808
    4. MLK4 is a negative regulator of TLR4 signaling. PMID: 21602844
  • 蛋白家族：
    Protein kinase superfamily, STE Ser/Thr protein kinase family, MAP kinase kinase kinase subfamily
  • 数据库链接：

    HGNC: 29798

    OMIM: 614793

    KEGG: hsa:84451

    STRING: 9606.ENSP00000355583

    UniGene: Hs.547779