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  4. MAP2K5 Antibody

MAP2K5 Antibody

  • 货号：
    CSB-PA080231
  • 规格：
    ￥880
  • 图片：
    • Immunohistochemical analysis of paraffin-embedded Human Breast Carcinoma using MEK-5 Polyclonal Antibody.
    • Western blot analysis of 1) Hela, 2) 3T3, 3) PC12 using MEK-5 Polyclonal Antibody.
  • 其他：

产品详情

  • Uniprot No.：
    Q13163
  • 基因名：
  • 别名：
    Dual specificity mitogen activated protein kinase kinase 5 antibody; Dual specificity mitogen-activated protein kinase kinase 5 antibody; EC 2.7.12.2 antibody; HsT17454 antibody; MAP kinase kinase 5 antibody; MAP kinase kinase MEK5b antibody; MAP2K5 antibody; MAPK/ERK kinase 5 antibody; MAPKK 5 antibody; MAPKK5 antibody; MEK 5 antibody; mitogen-activated protein kinase kinase 5 antibody; MKK5 antibody; MP2K5_HUMAN antibody; PRKMK5 antibody; Protein kinase, mitogen-activated, kinase 5 antibody; SAPKK5 antibody; SKK5 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse,Rat
  • 免疫原：
    Recombinant Protein
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 抗体亚型：
    IgG
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    PBS, pH 7.4, containing 0.02% sodium azide as Preservative and 50% Glycerol.
  • 产品提供形式：
    Liquid
  • 应用范围：
    WB, IHC
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:1000-2000
    IHC 1:200-500
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Acts as a scaffold for the formation of a ternary MAP3K2/MAP3K3-MAP3K5-MAPK7 signaling complex. Activation of this pathway appears to play a critical role in protecting cells from stress-induced apoptosis, neuronal survival and cardiac development and angiogenesis.
  • 基因功能参考文献：
    1. When yeast genetic interaction partners held in common between human OPTN and ANG were validated in mammalian cells and zebrafish, MAP2K5 kinase emerged as a potential drug target for amyotrophic lateral sclerosis therapy PMID: 28596290
    2. results confirmed the association of BTBD9 and MAP2K5/SKOR1 with primary Restless Legs Syndrome in Chinese population PMID: 28329290
    3. Results revealed the expression of MEK5 was higher in tumor tissues and provide evidence that MEK5 plays an important role in colorectal cancer progression. PMID: 27160304
    4. Insights into a molecular mechanism by which MEK5 transcriptionally upregulated by Stat3 augments breast cancer cell EMT, which subsequently enhances cancer cell invasion and metastasis. This finding may suggest that Stat3 and MEK5/Erk5 pathways could be an effective therapeutic target for inhibition of breast cancer invasion and metastasis. PMID: 27878304
    5. Our findings confirm an association between the BTBD9, MEIS1, and MAP2K5/SKOR1 SNPs and periodic limb movements of sleep in an elderly cohort. PMID: 26498236
    6. Specifically, CKS1B and MAP2K5 significantly inhibited hepatitis C viral RNA replication. PACSIN1, by contrast, inhibited hepatitis C virus infection by decreasing the level of viral protein p7. PMID: 24205826
    7. High MEK5 expression is associated with colorectal cancer. PMID: 25662172
    8. SEC16B, MC4R, MAP2K5 and KCTD15 (rs17782313, rs543874, rs2241423 and rs11084753) polymorphisms are associated with the risk for children obesity in China. PMID: 25637721
    9. Periodic leg movements during sleep are associated with polymorphisms in BTBD9, TOX3/BC034767, MEIS1, MAP2K5/SKOR1, and PTPRD PMID: 25142570
    10. MiR-330-3p and MAP2K5 are potentially important contributors to mood and anxiety-related traits PMID: 24436253
    11. Single nucleotide polymorphism in the MAP2K5 gene is associated with BMI and obesity. PMID: 22594783
    12. data indicate that the rs3743354 polymorphism in the MEK5 promoter may affect the risk of developing colorectal cancer PMID: 21861603
    13. Variants in MEIS1, BTBD9, and MAP2K5/SKOR1 confer a significant risk of restless legs syndrome in a United States population. PMID: 21925394
    14. Genistein can affect the ERK5 MAPK signaling transduction pathway and induce the expressions of apoptosis related proteins to inhibit the proliferation of MDA-MB-231 cells. PMID: 16758967
    15. overexpression of MEK5 in APO- MCF-7 breast carcinoma cells shows that this MAPK signaling protein represents a potent survival molecule. PMID: 12219026
    16. MEK5 overexpression is associated with metastatic prostate cancer, and stimulates proliferation, MMP-9 expression and invasion. MEK5 is a key signalling molecule associated with prostate carcinogenesis. PMID: 12618764
    17. alternative splicing of MEK5alpha and MEK5beta may play a critical role in BMK1 activation and subsequent cell proliferation PMID: 14583600
    18. nuclear localization of MEK5 and ERK5 is different from that of ERK1/2 and MEK1/2 in resting cells, indicating that each MAPK cascade uses distinct mechanisms PMID: 15075238
    19. MEK5 may be one of the Stat3-regulated genes and plays its essential roles in oncogenesis PMID: 15378007
    20. Data suggest that HGF-induced effects in some mesothelioma cells are mediated via activation of a novel PI3K/ERK5/Fra-1 feedback pathway PMID: 17872495
    21. ERK5 nuclear staining has been shown to be an independent marker of prognosis in CaP, and may prove useful as a stratification tool to identify a more aggressive/metastatic phenotype PMID: 18071319

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  • 蛋白家族：
    Protein kinase superfamily, STE Ser/Thr protein kinase family, MAP kinase kinase subfamily
  • 组织特异性：
    Expressed in many adult tissues. Abundant in heart and skeletal muscle.
  • 数据库链接：

    HGNC: 6845

    OMIM: 602520

    KEGG: hsa:5607

    STRING: 9606.ENSP00000178640

    UniGene: Hs.114198