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MAN2A1 Antibody

  • 货号：
    CSB-PA613697LA01HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Western Blot
      Positive WB detected in: HEK293 whole cell lysate, HepG2 whole cell lysate
      All lanes: MAN2A1 antibody at 3.5μg/ml
      Secondary
      Goat polyclonal to rabbit IgG at 1/50000 dilution
      Predicted band size: 132 kDa
      Observed band size: 150 kDa
    • Immunohistochemistry of paraffin-embedded human lung cancer using CSB-PA613697LA01HU at dilution of 1:100
    • Immunohistochemistry of paraffin-embedded human cervical cancer using CSB-PA613697LA01HU at dilution of 1:100
    • Immunofluorescent analysis of Hela cells using CSB-PA613697LA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) MAN2A1 Polyclonal antibody
  • Uniprot No.：
    Q16706
  • 基因名：
    MAN2A1
  • 别名：
    3-1 antibody; 6-alpha-mannosidase antibody; Alpha mannosidase 2 antibody; alpha Mannosidase II antibody; Alpha-mannosidase 2 antibody; AMAN II antibody; Golgi alpha mannosidase II antibody; Golgi alpha-mannosidase II antibody; Golgi integral membrane protein 7 antibody; GOLIM7 antibody; MA2A1_HUMAN antibody; MAN II antibody; Man2a1 antibody; MANA 2 antibody; MANA2 antibody; MANII antibody; Mann II antibody; Mannosidase alpha class 2A member 1 antibody; Mannosidase Two antibody; Mannosidase; alpha type II antibody; Mannosidase; alpha; II antibody; Mannosyl oligosaccharide 1 3 1 6 alpha mannosidase antibody; Mannosyl oligosaccharide 1,3 1,6 alpha mannosidase antibody; Mannosyl-oligosaccharide 1 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Recombinant Human Alpha-mannosidase 2 protein (31-181AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated

    本页面中的产品，MAN2A1 Antibody (CSB-PA613697LA01HU)，的标记方式是Non-conjugated。对于MAN2A1 Antibody，我们还提供其他标记。见下表：

    可提供标记
    标记方式 货号 产品名称 应用
    HRP CSB-PA613697LB01HU MAN2A1 Antibody, HRP conjugated ELISA
    FITC CSB-PA613697LC01HU MAN2A1 Antibody, FITC conjugated
    Biotin CSB-PA613697LD01HU MAN2A1 Antibody, Biotin conjugated ELISA
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    >95%, Protein G purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, WB, IHC, IF
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:500-1:5000
    IHC 1:20-1:200
    IF 1:50-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Catalyzes the first committed step in the biosynthesis of complex N-glycans. It controls conversion of high mannose to complex N-glycans; the final hydrolytic step in the N-glycan maturation pathway.
  • 基因功能参考文献：
    1. he QSAR models with the fragmented QM-DFT descriptors may find a useful application in structure-based drug design where pure empirical and force field methods reached their limits and where quantum mechanics effects are critical for ligand-receptor interactions. The optimized models will apply in lead optimization processes for GMII drug developments. PMID: 27035259
    2. Many human tumor types and cancer cell lines express the MAN2A1-FER fusion, which increases proliferation and invasiveness of cancer cell lines and has liver oncogenic activity in mice. PMID: 28245430
    3. The disruption of Golgi alpha-mannosidase II activity by swainsonine in human embryonic kidney cells is capable of inducing a novel class of hybrid-type glycosylation containing a partially processed mannose moiety. PMID: 17466984
    4. This article discribes experiments in which the MAN2A1 homologue in mouse was deleted, resulting in a systemic autoimmune disease in the mice which is similar to human systemic lupus erythematosus. PMID: 11158608
  • 亚细胞定位：
    Golgi apparatus membrane; Single-pass type II membrane protein.
  • 蛋白家族：
    Glycosyl hydrolase 38 family
  • 数据库链接：

    HGNC: 6824

    OMIM: 154582

    KEGG: hsa:4124

    STRING: 9606.ENSP00000261483

    UniGene: Hs.432822