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MAL Antibody

  • 货号：
    CSB-PA913398
  • 规格：
    ￥1100
  • 图片：
    • The image on the left is immunohistochemistry of paraffin-embedded Human liver cancer tissue using CSB-PA913398(MAL Antibody) at dilution 1/30, on the right is treated with synthetic peptide. (Original magnification: ×200)
    • The image on the left is immunohistochemistry of paraffin-embedded Human brain tissue using CSB-PA913398(MAL Antibody) at dilution 1/30, on the right is treated with synthetic peptide. (Original magnification: ×200)
  • 其他：

产品详情

  • Uniprot No.：
    P21145
  • 基因名：
    MAL
  • 别名：
    MAL; Myelin and lymphocyte protein; T-lymphocyte maturation-associated protein
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse,Rat
  • 免疫原：
    Synthetic peptide of Human MAL
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen affinity purification
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,IHC
  • 推荐稀释比：
    Application Recommended Dilution
    ELISA 1:2000-1:5000
    IHC 1:50-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Could be an important component in vesicular trafficking cycling between the Golgi complex and the apical plasma membrane. Could be involved in myelin biogenesis and/or myelin function.
  • 基因功能参考文献：
    1. In high-grade serous ovarian carcinoma patients, MAL was overexpressed in platinum-resistant compared to platinum-sensitive patients and resulted as an independent prognostic marker of survival. PMID: 28545541
    2. MAL and TMEM220 were specifically methylated and were down-regulated in human gastric cancer. PMID: 27329150
    3. This study revealed that Merkel cell polyomavirus -negative Merkel cell carcinomas significantly expressed higher CADM1 and lower MAL than Merkel cell polyomavirus -positive Merkel cell carcinomas PMID: 26772392
    4. CADM1/MAL methylation increases with severity of cervical intraepithelial neoplasia PMID: 26219541
    5. Hypermethylation of the selected markers (MAL, PRIMA1, PTGDR and SFRP1) can result in reduced gene expression and may contribute to the formation of colorectal cancer. PMID: 26482433
    6. Data suggest that expression of MAL in cells confers both ETX (Clostridium perfringens epsilon-toxin) binding and susceptibility to ETX-mediated cell death; cells expressing rat MAL are 100 times more sensitive to ETX than cells expressing human MAL. PMID: 25993478
    7. The use of CADM1, MAL, and MIR124-2 as biomarkers for full molecular screening in HIV infected women who are also positive for human papillomavirus. PMID: 26473640
    8. MAL is a critical element of the machinery for exosome secretion and may constitute a target for modulating exosome secretion by human T cells. PMID: 26109641
    9. MAL hypermethylation is associated with esophageal carcinoma progression. PMID: 24088706
    10. Cytology and bi-marker CADM1/MAL-methylation analysis perform complementary for CIN2+/CIN3+ detection when used as triage tool on cervical scrapes of HPV positive women. PMID: 25667975
    11. DNA methylation analysis of CADM1, MAL and miR124-2 in cervical scrapes consistently detects cervical cancer PMID: 25281766
    12. The MAL gene repression related with lymph node metastasis and poor prognosis in gastric cancer, suggesting that the MAL may be a new candidate node metastasis-suppressor gene for gastric cancer. PMID: 24511665
    13. CADM1 and MAL methylation levels increased proportional to severity of the underlying lesion PMID: 23456988
    14. hypomethylation of LINE-1 and hypermethylation of SLIT2, MAL and IGFBP7 were frequently detected in NSCLCs and associated with various clinical features. PMID: 23381221
    15. MAL protein plays an important role during oral carcinogenesis, MAL gene expression was significantly decreased in oral squamous cell carcinoma compared with normal epithelium. PMID: 23224601
    16. Data indicate that DNA methylation status of multiple genes CADM1, MAL and hsa-miR-124-2 was analyzed in human papillomavirus (hrHPV)-positive cervical scrape. PMID: 23176198
    17. the methylation marker panel CADM1-M18 and MAL-M1 may serve as an alternative molecular triage tool for hrHPV-positive women. PMID: 21190187
    18. Data show that a combination of CADM1 and MAL methylation could represent a promising candidate triage tool for hrHPV-positive women. PMID: 21389098
    19. MAL is normally expressed in laryngeal epithelial cells and its expression changes at early stages of carcinoma development. PMID: 19670627
    20. This study supports roles for tyrosines 86 and 106 in signaling pathways involving MAL. PMID: 20822478
    21. Data suggest that the epigenetic inactivation of MAL, as a candidate tumor suppressor gene, can contribute to human epithelial cell carcinoma and may be served as a biomarker in HNSCC. PMID: 21092172
    22. The caspase-1 cleavage site in Mal is part of a TIR-domain interaction site. PMID: 20048342
    23. Data show that MAL transcript levels were higher in the resistant ovarian cell lines. PMID: 19642140
    24. The mal gene which is switched-off in all esophageal squamous cell carcinoma samples can be considered as a tumor suppressor gene PMID: 15188492
    25. Caveolin-1 and MAL are located on prostasomes secreted by prostate cancer cells PMID: 15466889
    26. Quantitative analysis carried out using pixel intensity variance demonstrated that the MAL protein is capable of modifying the plasma membrane, thereby increasing its resistance to detergent-induced pore formation. PMID: 16785208
    27. Loss of MAL expression is aasociated with precancerous lesions of the esophagus PMID: 17151798
    28. Promoter hypermethylation of MAL, shown to be present in colorectal adenomas and carcinomas and only rarely in normal mucosa. PMID: 17408629
    29. promoter hypermethylation of MAL was present in the vast majority of benign and malignant colorectal tumors, and only rarely in normal mucosa PMID: 18346269
    30. MAL has a putative tumour-suppressor gene function in gastric cancer, and detection of promoter hypermethylation may be useful as a prognostic marker. PMID: 19002170
    31. Inactivation of the MAL gene in breast cancer is a common event that predicts benefit from adjuvant chemotherapy. PMID: 19208741
    32. suggesting the MAL gene as a new metastasis-suppressor candidate for head and neck cancer PMID: 19445022

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  • 亚细胞定位：
    Membrane; Multi-pass membrane protein.
  • 蛋白家族：
    MAL family
  • 数据库链接：

    HGNC: 6817

    OMIM: 188860

    KEGG: hsa:4118

    STRING: 9606.ENSP00000310880

    UniGene: Hs.80395