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MAF Antibody

  • 货号：
    CSB-PA903964
  • 规格：
    ￥1100
  • 图片：
    • The image on the left is immunohistochemistry of paraffin-embedded Human liver cancer tissue using CSB-PA903964(MAF Antibody) at dilution 1/50, on the right is treated with synthetic peptide. (Original magnification: ×200)
    • The image on the left is immunohistochemistry of paraffin-embedded Human esophagus cancer tissue using CSB-PA903964(MAF Antibody) at dilution 1/50, on the right is treated with synthetic peptide. (Original magnification: ×200)
    • Gel: 8%SDS-PAGE, Lysate: 40 μg, Lane 1-4: A431 cells, A375 cells, hela cells, Jurkat cells, Primary antibody: CSB-PA903964(MAF Antibody) at dilution 1/1100, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 5 seconds
  • 其他：

产品详情

  • Uniprot No.：
    O75444
  • 基因名：
  • 别名：
    AS42 oncogene homolog antibody; Avian musculoaponeurotic fibrosarcoma (MAF) protooncogene antibody; Avian musculoaponeurotic fibrosarcoma (v maf) antibody; c maf proto oncogene antibody; cMaf antibody; maf antibody; MAF_HUMAN antibody; MAF2 antibody; MGC71685 antibody; Proto oncogene c Maf antibody; Proto-oncogene c-maf antibody; Transcription factor Maf antibody; v maf musculoaponeurotic fibrosarcoma oncogene homolog (avian) antibody; v maf musculoaponeurotic fibrosarcoma oncogene homolog antibody; V-maf musculoaponeurotic fibrosarcoma oncogene homolog antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse,Rat
  • 免疫原：
    Synthetic peptide of Human MAF
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen affinity purification
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,WB,IHC
  • 推荐稀释比：
    Application Recommended Dilution
    ELISA 1:1000-1:5000
    WB 1:1000-1:5000
    IHC 1:50-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Acts as a transcriptional activator or repressor. Involved in embryonic lens fiber cell development. Recruits the transcriptional coactivators CREBBP and/or EP300 to crystallin promoters leading to up-regulation of crystallin gene during lens fiber cell differentiation. Activates the expression of IL4 in T helper 2 (Th2) cells. Increases T-cell susceptibility to apoptosis by interacting with MYB and decreasing BCL2 expression. Together with PAX6, transactivates strongly the glucagon gene promoter through the G1 element. Activates transcription of the CD13 proximal promoter in endothelial cells. Represses transcription of the CD13 promoter in early stages of myelopoiesis by affecting the ETS1 and MYB cooperative interaction. Involved in the initial chondrocyte terminal differentiation and the disappearance of hypertrophic chondrocytes during endochondral bone development. Binds to the sequence 5'-[GT]G[GC]N[GT]NCTCAGNN-3' in the L7 promoter. Binds to the T-MARE (Maf response element) sites of lens-specific alpha- and beta-crystallin gene promoters. Binds element G1 on the glucagon promoter. Binds an AT-rich region adjacent to the TGC motif (atypical Maf response element) in the CD13 proximal promoter in endothelial cells. When overexpressed, represses anti-oxidant response element (ARE)-mediated transcription. Involved either as an oncogene or as a tumor suppressor, depending on the cell context. Binds to the ARE sites of detoxifying enzyme gene promoters.
  • 基因功能参考文献：
    1. common variant , rs889472, of c-MAF is associated with gout susceptibility. PMID: 29080939
    2. we identified two heterozygous rare variants in genes that are involved in early cataract development; the novel c.809C>A; p.(Ser270Tyr) in MAF and the c.168C>G; p.(Tyr56 *) variant in CRYGD, previously reported as pathogenic PMID: 28849415
    3. UBE2O mediates c-Maf polyubiquitination and degradation, induces MM cell apoptosis, and suppresses myeloma tumor growth, which provides a novel insight in understanding myelomagenesis and UBE2O biology. PMID: 28673317
    4. The interaction between c-Maf and RORgammat, and Blimp-1. PMID: 28300844
    5. Polymorphisms rs9939609 (FTO gene) and rs1424233 (MAF gene) were genotyped using allelic discrimination assays in a prospective multicenter cohort study; these polymorphisms did not show associations with birth weight, BMI and Ponderal Index at discharge, and weight gain, neither testing for a dominant, additive nor for a recessive model. PMID: 23840443
    6. this study shows that genes associated with MAF-binding enhancers are suppressed in macrophages isolated from rheumatoid-arthritis patients, revealing a disease-associated signature of IFN-gamma-mediated repression PMID: 28813657
    7. Our results argued that increased expression of sIL6R from myeloid cells and subsequent c-Maf induction were adverse events for counteracting tumor-specific Th1 generation. Overall, this work provides a mechanistic rationale for sIL6R targeting to improve the efficacy of T-cell-mediated cancer immunotherapy PMID: 28235765
    8. These results define the role of MAF and GSK3 in the resistance of t(14;16) multiple myeloma to proteasome inhibitors. PMID: 27793878
    9. interplay between MATalpha1, c-Myc, and Maf proteins, and their deregulation during chronic cholestasis may facilitate cholangiocarcinoma oncogenesis PMID: 26969892
    10. Epidermal differentiation gene regulatory networks are controlled by MAF and MAFB. PMID: 27097296
    11. Findings implicate the strong effects of ROS on multiple stem cell functions with a central role for c-Maf in stem cell senescence. PMID: 26496036
    12. Collectively, these studies show that FGF signaling up-regulates expression of alphaA-crystallin both directly and indirectly via up-regulation of c-Maf. PMID: 26719333
    13. Results suggest that MAF is a mediator of breast cancer bone metastasis. 16q23 gain or MAF protein overexpression in tumors may help to select patients at risk of bone relapse. PMID: 26376684
    14. Differential effect of cataract-associated mutations in MAF on transactivation of MAF target crystalline genes. PMID: 25064449
    15. Study added a novel insight for c-MAF ubiquitination and degradation, suggesting that c-MAF stability is strictly regulated. PMID: 25448412
    16. Disease-causing mutations were demonstrated to impair proper MAF phosphorylation, ubiquitination and proteasomal degradation, perturbed gene expression in primary skin fibroblasts, and induced neurodevelopmental defects in an in vivo model. PMID: 25865493
    17. MAF has a role in mediating crosstalk between Ras-MAPK and mTOR signaling in NF1 PMID: 24509877
    18. LPS promotes PDCD4 degradation via a pathway involving PI3K and mTOR, releasing Twist2, which induces IL-10 via c-Maf. PMID: 24982420
    19. Results imply a regulatory role for TMEM18, BDNF, MTCH2 and NEGR1 in adipocyte differentiation and biology. In addition, we show a variation of MAF expression during adipogenesis, while NPC1, PTER and SH2B1 were not regulated. PMID: 23229156
    20. c-Maf increases human immunodeficiency virus (HIV)-1 expression in interleukin (IL)-4-producing CD4 T cells by binding the proximal HIV-1 long terminal repeat region (LTR) and augmenting HIV-1 transcription. PMID: 22875803
    21. Bcl6 and Maf collaborate to orchestrate a suite of genes that define core characteristics of human Tfh cell biology. PMID: 22427637
    22. findings show that the transcription factor c-Maf/c-MAF is crucial for mechanosensory function; sensitivity to high-frequency vibration is reduced in humans carrying a dominant mutation in the c-MAF gene PMID: 22345400
    23. we studied the mechanisms underlying IL-2 regulation of C-MAF expression in human T cells PMID: 21876034
    24. Hepatitis C virus impairs the induction of cytoprotective Nrf2 target genes by delocalization of small Maf proteins. PMID: 21216956
    25. the MEK-ERK pathway regulates MAF transcription PMID: 21163924
    26. Methionine adenosyltransferase II serves as a transcriptional corepressor of Maf oncoprotein PMID: 21362551
    27. Monocyte-derived macrophages with CD14 of high-antigen positivity display increased expression of c-Maf, which upregulates production of two key factors (hyaluronan and interleukin-10) that promote growth of Mycobacterium tuberculosis. PMID: 21209279
    28. c-Maf interacts with Ubc9 & PIAS1. c-Maf can be SUMOylated at Lys-33 in vitro. SUMOylation attenuates its transcriptional activity. PMID: 20127678
    29. Taken together, these studies demonstrate a new level of transcriptional regulation of MMP-13 expression by the c-maf. PMID: 20067416
    30. novel role for MAF as a transcriptional repressor, preventing expression of blood vessel endothelial cells-specific genes, thereby maintaining the differentiation status of lymphatic endothelial cells PMID: 20080955
    31. results suggest that Tc-mip plays a critical role in Th2 signaling pathway and represents the first proximal signaling protein which links TCR-mediated signal to the activation of c-maf Th2 specific factor PMID: 12939343
    32. The short form of the proto-oncogene c-maf is highly induced in minimal change nephrotic syndrome T cells during relapse, where it translocates to the nuclear compartment and binds to the DNA responsive element. PMID: 14688382
    33. High levels of c-maf mRNA is associated with multiple myeloma PMID: 14692531
    34. c-maf transforms plasma cells by stimulating cell cycle progression and by altering bone marrow stromal interactions PMID: 14998494
    35. role of c-Maf in the transcriptional regulation of IL-10 and the underlying molecular mechanism in macrophages PMID: 15749884
    36. results suggest that c-Maf might cause a type of T-cell lymphoma in both mice and humans and that ARK5, in addition to cyclin D2 and integrin beta(7), might be downstream target genes of c-Maf leading to malignant transformation PMID: 16424013
    37. Findings expand the mutation spectrum of MAF in association with congenital cataract and highlight the genetic and phenotypic heterogeneity of congenital cataract. PMID: 16470690
    38. Segmental allergen challenge in asthmatics leads to increased GATA-3, c-maf and T-bet expression in BAL cells but not in bronchial biopsies PMID: 16498264
    39. OPN is significantly upregulated in MM patients with maf translocations, particularly in the fraction lacking bone disease PMID: 17044113
    40. c-Maf is capable of interactions with c-Myb that lead to reduced promoter binding and decreased Bcl-2 expression, rendering CD4 T cells more prone to apoptosis. PMID: 17823980
    41. the differential DNA binding specificity between Maf homodimers and Nrf2-Maf heterodimers establishes the differential gene regulation by these dimer-forming transcription factors PMID: 17875642
    42. CD13 transcription is regulatd by MAF via an atypical response element. PMID: 17897790
    43. Pax-6 and c-Maf interact with G1 to activate basal expression of the glucagon gene PMID: 17901057
    44. MAF mutation p.Arg299Ser is the third mutation identified in association with the CCMC phenotype, and all three mutations are located in the basic region of the DNA binding domain in the MAF protein (OMIM 177075). PMID: 17982426
    45. Angioimmunoblastic T-cell lymphoma(AILT) shows c-Maf expression and provide new insight into the pathogenesis of AILT suggesting c-Maf to be a useful diagnostic marker. PMID: 18059226
    46. MafG-mediated nuclear retention may enable Nrf2 proteins to evade cytosolic proteasomal degradation and consequently stabilize Nrf2 signaling PMID: 18585411
    47. The exclusion of these genes as likely candidates supports the hypothesis that the ocular phenotype associated with peters' anomaly segregating in this family is a distinct, new, autosomal dominant entity in the anterior segment dysgenesis spectrum. PMID: 18616618
    48. In addition to FTO and MC4R, we detected significant association of obesity with three new risk loci in NPC1 (endosomal/lysosomal Niemann-Pick C1 gene), near MAF (encoding the transcription factor c-MAF) and near PTER (phosphotriesterase-related gene). PMID: 19151714
    49. c-maf may be important in chondrocyte hypertrophy and terminal differentiation, and may be involved in the pathogenesis of osteoarthritis PMID: 19215682
    50. detection of c-Maf may be of particular value in the differential diagnosis of small cell lymphomas. PMID: 19687312

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  • 相关疾病：
    Cataract 21, multiple types (CTRCT21); Ayme-Gripp syndrome (AYGRP)
  • 亚细胞定位：
    Nucleus.
  • 蛋白家族：
    BZIP family, Maf subfamily
  • 组织特异性：
    Expressed in endothelial cells.
  • 数据库链接：

    HGNC: 6776

    OMIM: 177075

    KEGG: hsa:4094

    STRING: 9606.ENSP00000327048

    UniGene: Hs.134859