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MAB21L2 Antibody

  • 货号：
    CSB-PA896901LA01HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Western Blot
      Positive WB detected in: Mouse liver tissue
      All lanes: MAB21L2 antibody at 3μg/ml
      Secondary
      Goat polyclonal to rabbit IgG at 1/50000 dilution
      Predicted band size: 41 kDa
      Observed band size: 41 kDa
    • Immunofluorescent analysis of Hela cells using CSB-PA896901LA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
  • 其他：

产品详情

  • 产品描述：

    To generate the MAB21L2 polyclonal antibody, the recombinant human MAB21L2 protein (1-300aa) is used to immunize a rabbit. The rabbit's immune system will recognize the immunogen as foreign and produce antibodies against it. After several rounds of immunization, blood is collected from the rabbit and the serum is isolated. The MAB21L2 polyclonal antibodies are purified from the rabbit's serum using protein G affinity chromatography. The purity of this MAB21L2 antibody is 95%+. This MAB21L2 antibody can be used to detect human and mouse MAB21L2 proteins in ELISA, WB, and IF applications.

    The MAB21L2 protein is a transcription factor that is involved in regulating the development of various tissues and organs in the body. Specifically, it plays a role in eye development, neural tube closure, and kidney development. Mutations in the MAB21L2 gene can lead to renal disorders and affect cell proliferation and differentiation in other tissues.

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) MAB21L2 Polyclonal antibody
  • Uniprot No.：
    Q9Y586
  • 基因名：
    MAB21L2
  • 别名：
    MAB21L2 antibody; Protein mab-21-like 2 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human, Mouse
  • 免疫原：
    Recombinant Human Protein mab-21-like 2 protein (1-300AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated

    本页面中的产品，MAB21L2 Antibody (CSB-PA896901LA01HU)，的标记方式是Non-conjugated。对于MAB21L2 Antibody，我们还提供其他标记。见下表：

    可提供标记
    标记方式 货号 产品名称 应用
    HRP CSB-PA896901LB01HU MAB21L2 Antibody, HRP conjugated ELISA
    FITC CSB-PA896901LC01HU MAB21L2 Antibody, FITC conjugated
    Biotin CSB-PA896901LD01HU MAB21L2 Antibody, Biotin conjugated ELISA
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    >95%, Protein G purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, WB, IF
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:500-1:5000
    IF 1:50-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Required for several aspects of embryonic development including normal development of the eye.
  • 基因功能参考文献：
    1. mab21 gene family members, mab21l1 and mab21l2, play important roles in regulating eye development. [review] PMID: 27558071
    2. The two unrelated individuals with a novel oculo-skeletal syndrome with intellectual disability described are heterozygous carriers of the same de novo missense mutation c.151C > T (p.Arg51Cys) in MAB21L2. PMID: 26116559
    3. These findings support the identification of MAB21L2 as a novel factor involved in human coloboma and highlight the power of genome editing manipulation in model organisms for analysis of the effects of whole exome variation in humans. PMID: 25719200
    4. This report provides compelling human genomic and genetic evidence that mutations in MAB21L2 cause major eye malformations. PMID: 24906020
  • 相关疾病：
    Microphthalmia/coloboma and skeletal dysplasia syndrome (MCSKS)
  • 亚细胞定位：
    Nucleus. Cytoplasm.
  • 蛋白家族：
    Mab-21 family
  • 数据库链接：

    HGNC: 6758

    OMIM: 604357

    KEGG: hsa:10586

    STRING: 9606.ENSP00000324701

    UniGene: Hs.584852