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Ltbp1 Antibody

  • 货号：
    CSB-PA807018LA01MO
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Mus musculus (Mouse) Ltbp1 Polyclonal antibody
  • Uniprot No.：
    Q8CG19
  • 基因名：
  • 别名：
    Ltbp1Latent-transforming growth factor beta-binding protein 1 antibody; LTBP-1 antibody; Transforming growth factor beta-1-binding protein 1 antibody; TGF-beta1-BP-1 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Mouse
  • 免疫原：
    Recombinant Mouse Latent-transforming growth factor beta-binding protein 1 protein (20-299AA)
  • 免疫原种属：
    Mus musculus (Mouse)
  • 标记方式：
    Non-conjugated

    本页面中的产品，Ltbp1 Antibody (CSB-PA807018LA01MO)，的标记方式是Non-conjugated。对于Ltbp1 Antibody，我们还提供其他标记。见下表：

    可提供标记
    标记方式 货号 产品名称 应用
    HRP CSB-PA807018LB01MO Ltbp1 Antibody, HRP conjugated ELISA
    FITC CSB-PA807018LC01MO Ltbp1 Antibody, FITC conjugated
    Biotin CSB-PA807018LD01MO Ltbp1 Antibody, Biotin conjugated ELISA
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    >95%, Protein G purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

引用文献

产品评价

靶点详情

  • 功能：
    Key regulator of transforming growth factor beta (TGFB1, TGFB2 and TGFB3) that controls TGF-beta activation by maintaining it in a latent state during storage in extracellular space. Associates specifically via disulfide bonds with the Latency-associated peptide (LAP), which is the regulatory chain of TGF-beta, and regulates integrin-dependent activation of TGF-beta. Outcompeted by LRRC32/GARP for binding to LAP regulatory chain of TGF-beta.
  • 基因功能参考文献：
    1. LTBP1 has a role in female reproduction PMID: 27956181
    2. Data show the complete knockout of both isoforms of LTBP-1 leads to defective cardiovascular development and subsequent perinatal lethality supporting the idea that LTBP-1 is essential in the development of the great arteries and cardiac cushions. PMID: 25805620
    3. Ltbp1 functions in a mechanosensory capacity to establish and maintain mammary gland ductal luminal cell fate, support and detect ductal distension, trigger irreversible involution, and facilitate nipple sphincter function. PMID: 24262428
    4. a detailed computational model for TGF-beta signalling that incorporates elements of previous models together with crosstalking between Smad1/5/8 and Smad2/3 channels through a negative feedback loop dependent on Smad7. PMID: 23804438
    5. miR-133a mediates TGF-beta-dependent derepression of collagen synthesis in hepatic stellate cells during liver fibrosis. PMID: 23183523
    6. High transforming Growth Factor beta1 expression is associated with myelofibrosis. PMID: 23462118
    7. results suggest a role for VEGFA-driven tumour growth by TGF-beta signalling inhibition via paracrine mechanisms in vivo PMID: 22045186
    8. Study reports that master transcription factors also are responsible for directing the gene targets of TGF-beta signaling and thus determine the cell-type-specific effects of TGF-beta signaling. PMID: 22036565
    9. requirement for TGF-beta signaling into T cells to achieve peripheral CD8 but not CD4 T-cell tolerance PMID: 21422469
    10. Ltbp1L is a major regulator of Tgf-beta activity during valvulogenesis since its absence results in a perturbed Tgf-beta pathway that causes all Ltbp1L(-/-) valvular defects. PMID: 21181942
    11. Shows that Latent Tgfbeta Binding protein 1 (LTBP1), which is a key extracellular modulator of Tgfbeta ligand bioavailability, is coexpressed with Tgfbetas in the early limb bud. PMID: 20565961
    12. IGFBP-3 can bind to LTBP-1 and provide a potential mechanism whereby IGFBP-3 can interact with the TGF-beta system PMID: 12962157
    13. fibronectin has a role in LTBP1 assembly in the ECM and in regulation of TGF beta via LTBP1 interactions PMID: 15677465
    14. integrin alphavbeta6-mediated activation of latent TGF-beta complexes containing LTBP-1 requires fibronectin PMID: 16260650
    15. Cleavage of LTBP1 by BMP1 is involved in TGFbeta1 activation. PMID: 17015622
    16. Data show that the lack of Ltbp1L in the extracellular matrix of the septating cardiac outflow tract and associated vessels results in altered gene expression and function of cardiac neural crest cells and decreased Tgf-beta activity in the OFT. PMID: 17804598
    17. LTBP-1 has essential functions in the control of TGF-beta activation PMID: 17950478
    18. AhR regulates Ltbp-1 transcription by a mechanism involving recruitment of co-activators such as CREB1 and co-repressors such as HDAC2 to the Ltbp-1 promoter. PMID: 18508077
    19. Blocking Tgfb-Smad2/3 innate immune signaling mitigates Alzheimer-like pathology. PMID: 18516051
    20. When TGF-beta activity would inhibit further maturation and mineralization, LTBP-1 containing large latent TGF-beta1 complexes that accumulate into the ECM and represent targets for osteoclast mediated release and activation of TGF-beta in bone tissue. PMID: 18672106
    21. Data suggest that association of latent TGF-beta binding protein (LTBP) with the latent TGF-beta complex is important for proper TGF-beta1 function. PMID: 19022904
    22. The long form of LTBP1 (LTBP-1L) is essential for proper heart development. PMID: 17804598

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  • 亚细胞定位：
    Secreted. Secreted, extracellular space, extracellular matrix.
  • 蛋白家族：
    LTBP family
  • 数据库链接：

    KEGG: mmu:268977

    STRING: 10090.ENSMUSP00000001927

    UniGene: Mm.269747