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LZTS1 Antibody

  • 货号：
    CSB-PA22699A0Rb
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • IHC image of CSB-PA22699A0Rb diluted at 1:500 and staining in paraffin-embedded human prostate tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
    • Immunofluorescence staining of HepG2 cells with CSB-PA22699A0Rb at 1:166, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) LZTS1 Polyclonal antibody
  • Uniprot No.：
    Q9Y250
  • 基因名：
    LZTS1
  • 别名：
    F37 antibody; F37/esophageal cancer related gene coding leucine zipper motif antibody; F37/esophageal cancer-related gene-coding leucine-zipper motif antibody; Fez1 antibody; Leucine zipper putative tumor suppressor 1 antibody; Lzts1 antibody; LZTS1_HUMAN antibody; Psdzip70 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Recombinant Human Leucine zipper putative tumor suppressor 1 protein (47-212AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated

    本页面中的产品，LZTS1 Antibody (CSB-PA22699A0Rb)，的标记方式是Non-conjugated。对于LZTS1 Antibody，我们还提供其他标记。见下表：

    可提供标记
    标记方式 货号 产品名称 应用
    HRP CSB-PA22699B0Rb LZTS1 Antibody, HRP conjugated ELISA
    FITC CSB-PA22699C0Rb LZTS1 Antibody, FITC conjugated
    Biotin CSB-PA22699D0Rb LZTS1 Antibody, Biotin conjugated ELISA
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    >95%, Protein G purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, IHC, IF
  • 推荐稀释比：
    Application Recommended Dilution
    IHC 1:500-1:1000
    IF 1:50-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Involved in the regulation of cell growth. May stabilize the active CDC2-cyclin B1 complex and thereby contribute to the regulation of the cell cycle and the prevention of uncontrolled cell proliferation. May act as a tumor suppressor.
  • 基因功能参考文献：
    1. missense variant in the LZTS1 gene was identified in two Ehlers-Danlos syndrome patients in an extended family. PMID: 26504261
    2. LZTS1 promoter was frequently methylated in IMPC samples. PMID: 25813822
    3. Compared with the normal hepatocyte cells, LZTS1 expression in hepatocellular carcinoma cells was significantly lower PMID: 26653561
    4. miR-135b expression inversely correlated with LZTS1 staining intensity and the Cutaneous Squamous Cell Carcinoma grade. PMID: 25938461
    5. Suggest that LZTS1 plays a potential tumor suppressor role in colorectal cancer progression and represents a valuable clinical prognostic marker of this disease. PMID: 25667121
    6. Lzts1 was significantly downregulated in breast cancer samples and its deregulation was associated with a higher incidence of tumor recurrence, and to a worse overall survival. PMID: 24448468
    7. miR-214 functions as an onco-miRNA in osteosarcoma, and its oncogenic effects are mediated chiefly through downregulation of LZTS1 PMID: 24802407
    8. Expression of miR-135b, LZTS1, LATS2 and nuclear TAZ predicts poor outcomes of non-small-cell lung cancer. PMID: 23695671
    9. Lower levels of leucine zipper putative tumor suppressor 1 correlated with high histologic grade, lymph node metastasis, and poor prognosis. PMID: 21419475
    10. variation in the germline sequence is associated with prostate cancer risk PMID: 12377406
    11. Down-regulation of FEZ1/LZTS1 gene with frequent loss of heterozygosity is associated with oral squamous cell carcinomas PMID: 12851677
    12. Forced expression of LZTS1 in metastasizing uveal melanoma cells inhibited their motility and invasion, whereas depletion of LZTS1 increased their motility. PMID: 18559591
    13. Down-regulation of tumor suppressor gene FEZ1/LZTS1 in breast carcinoma involves promoter methylation and associates with metastasis. PMID: 18686028
    14. The reduction or loss of FEZ1 protein could be an aid to the clinical management of patients affected by ovarian carcinoma. PMID: 19885841

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  • 相关疾病：
    Esophageal cancer (ESCR)
  • 亚细胞定位：
    Cytoplasm. Cell membrane. Cell projection, dendritic spine. Cell junction, synapse, postsynaptic density. Cell junction, synapse.
  • 蛋白家族：
    LZTS family
  • 组织特异性：
    Highly expressed in testis, prostate, spleen, thymus, ovary and brain. Detected at lower levels in heart, placenta, small intestine, colon, liver, kidney, skeletal muscle and pancreas. Not detectable in primary tumors from breast and prostate and in many
  • 数据库链接：

    HGNC: 13861

    OMIM: 133239

    KEGG: hsa:11178

    STRING: 9606.ENSP00000265801

    UniGene: Hs.521432