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LZTR1 Antibody

  • 货号：
    CSB-PA836674ESR1HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Immunohistochemistry of paraffin-embedded human heart tissue using CSB-PA836674ESR1HU at dilution of 1:100
    • Immunohistochemistry of paraffin-embedded human skeletal muscle tissue using CSB-PA836674ESR1HU at dilution of 1:100
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) LZTR1 Polyclonal antibody
  • Uniprot No.：
    Q8N653
  • 基因名：
    LZTR1
  • 别名：
    Leucine zipper like regulator 1 antibody; Leucine zipper like transcription regulator 1 antibody; Leucine-zipper-like transcriptional regulator 1 antibody; LZTR-1 antibody; Lztr1 antibody; LZTR1_HUMAN antibody; MGC21205 antibody; TCFL2 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Recombinant Human Leucine-zipper-like transcriptional regulator 1 protein (300-545AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen Affinity Purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, IHC
  • 推荐稀释比：
    Application Recommended Dilution
    IHC 1:20-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex that mediates ubiquitination of Ras (K-Ras/KRAS, N-Ras/NRAS and H-Ras/HRAS). Is a negative regulator of RAS-MAPK signaling that acts by controlling Ras levels and decreasing Ras association with membranes.
  • 基因功能参考文献：
    1. the malignancy risk in schwannomatosis is not well defined but may include an increased risk of malignant peripheral nerve sheath tumor in SMARCB1 Imaging protocols are also proposed for SMARCB1 and LZTR1 schwannomatosis and SMARCE1-related meningioma predisposition. PMID: 28620005
    2. Nerve lesions and LZTR1 germline mutations in segmental schwannomatosis. PMID: 27472264
    3. Data indicate that molecular analysis of leucine-zipper-like transcription regulator 1 (LZTR1) may contribute to the molecular characterization of schwannomatosis patients. PMID: 25335493
    4. We show for the first time that an inherited mutation in PBRM1 predisposes to RCC. PMID: 25795793
    5. Data confirm the relationship between mutations in LZTR1 and schwannomatosis. They indicate that germline mutations in LZTR1 confer an increased risk of vestibular schwannoma. PMID: 25480913
    6. Germline loss-of-function mutations in LZTR1 predispose to an inherited disorder of multiple schwannomas. PMID: 24362817
    7. LZTR-1 is the first BTB-kelch protein that exclusively localizes to the Golgi network PMID: 16356934

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  • 相关疾病：
    Schwannomatosis 2 (SWNTS2); Noonan syndrome 10 (NS10)
  • 亚细胞定位：
    Endomembrane system. Recycling endosome. Golgi apparatus.
  • 数据库链接：

    HGNC: 6742

    OMIM: 600574

    KEGG: hsa:8216

    STRING: 9606.ENSP00000215739

    UniGene: Hs.78788