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LYL1 Antibody

  • 货号：
    CSB-PA009891
  • 规格：
    ￥880
  • 其他：

产品详情

  • Uniprot No.：
    P12980
  • 基因名：
    LYL1
  • 别名：
    bHLHa18 antibody; Class A basic helix-loop-helix protein 18 antibody; Lyl1 antibody; LYL1_HUMAN antibody; Lymphoblastic leukemia derived sequence 1 antibody; Lymphoblastic leukemia-derived sequence 1 antibody; lymphoblastomic leukemia 1 antibody; Protein lyl 1 antibody; Protein lyl-1 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse,Rat
  • 免疫原：
    Synthesized peptide derived from the Internal region of Human Lyl-1.
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 抗体亚型：
    IgG
  • 纯化方式：
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 产品提供形式：
    Liquid
  • 应用范围：
    IHC, ELISA
  • 推荐稀释比：
    Application Recommended Dilution
    IHC 1:100-1:300
    ELISA 1:10000
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 基因功能参考文献：
    1. Despite not being identified as an independent prognostic factor in UCEC, LYL1 gene amplification is associated with other poor prognostic factors and correlated with upregulation of cancer-related pathways. PMID: 29716549
    2. In t(8;21) leukemia cells, LYL1 functions as a component of the stable AML1-ETO-containing transcription factor complex (AETFC). The AETFC components cooperatively regulate gene expression and contribute to leukemogenesis. PMID: 23812588
    3. LYL1 degradation is directed by a N-terminal PEST rich site in a phosphorylation-independent manner. PMID: 20844761
    4. LYL1 activity is required for the maturation of newly formed blood vessels in adulthood. PMID: 20418284
    5. Over-expression of LYL1 is highly associated with AML as well as ALL. PMID: 19176012
    6. Multiple mechanisms which activate LYL1 in leukemic cells, including structural genomic alterations, namely microdeletion or amplification, together with the involvement of prominent oncogenic transcription factors. PMID: 19608273
    7. LYL1 may play a role in early hematopoiesis and may be a potential oncogenic factor in AML PMID: 16094422
    8. Lyl1 interacts with CREB1 and alters expression of CREB1 target genes. PMID: 18160048

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  • 相关疾病：
    A chromosomal aberration involving LYL1 may be a cause of a form of T-cell acute lymphoblastic leukemia (T-ALL). Translocation t(7;19)(q35;p13) with TCRB.
  • 亚细胞定位：
    Nucleus.
  • 数据库链接：

    HGNC: 6734

    OMIM: 151440

    KEGG: hsa:4066

    STRING: 9606.ENSP00000264824

    UniGene: Hs.46446