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  4. LSM4 Antibody

LSM4 Antibody

  • 货号：
    CSB-PA013207GA01HU
  • 规格：
    ￥3,900
  • 其他：

产品详情

  • Uniprot No.：
    Q9Y4Z0
  • 基因名：
    LSM4
  • 别名：
    LSM4U6 snRNA-associated Sm-like protein LSm4 antibody; Glycine-rich protein antibody; GRP antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse,Rat
  • 免疫原：
    Human LSM4
  • 免疫原种属：
    Homo sapiens (Human)
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen Affinity Purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,WB,IHC
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Plays role in pre-mRNA splicing as component of the U4/U6-U5 tri-snRNP complex that is involved in spliceosome assembly, and as component of the precatalytic spliceosome (spliceosome B complex). The heptameric LSM2-8 complex binds specifically to the 3'-terminal U-tract of U6 snRNA.
  • 基因功能参考文献：
    1. Results show that the RGG domain of human Lsm4 stimulates processing bodies formation. Also, a novel interaction of the Lsm4 RGG domain with HAT1 and RBBP7 was discovered, leading to the possibility of a posttranslational modifications network involved in mRNP regulation. PMID: 27247266
    2. C-terminal extension of Lsm4 interacts directly with the histone mRNP, contacting both SLBP and 3'hExo. PMID: 24255165
    3. Data show that ICln159, a truncated ICln mutant, belongs to the pleckstrin homology (PH) domain family of proteins and interacts with LSm4, a protein involved in splicing and mRNA degradation. PMID: 15905169
    4. Gene induces transformed phenotype when overexpressed in a cancer breast cell line. PMID: 17178857
    5. LSm4 not only acts in RNA processing, but also as a co-factor in cell volume regulation. PMID: 19088440

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  • 亚细胞定位：
    Nucleus.
  • 蛋白家族：
    SnRNP Sm proteins family
  • 数据库链接：

    HGNC: 17259

    OMIM: 607284

    KEGG: hsa:25804

    STRING: 9606.ENSP00000469468

    UniGene: Hs.515255