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LSAMP Antibody

  • 货号：
    CSB-PA013197LA01HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Western Blot
      Positive WB detected in: Rat brain tissue, Rat liver tissue, Mouse brain tissue, Mouse liver tissue
      All lanes: LSAMP antibody at 4.2μg/ml
      Secondary
      Goat polyclonal to rabbit IgG at 1/50000 dilution
      Predicted band size: 38 kDa
      Observed band size: 38 kDa
    • Immunofluorescence staining of A549 cells with CSB-PA013197LA01HU at 1:66, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) LSAMP Polyclonal antibody
  • Uniprot No.：
    Q13449
  • 基因名：
    LSAMP
  • 别名：
    IgLON family member 3 antibody; IGLON3 antibody; Lam antibody; LAMP antibody; Limbic system associated membrane protein antibody; Limbic system associated membrane protein precursor antibody; Limbic system-associated membrane protein antibody; LSAMP antibody; LSAMP_HUMAN antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human, Mouse, Rat
  • 免疫原：
    Recombinant Human Limbic system-associated membrane protein (168-287AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated

    本页面中的产品，LSAMP Antibody (CSB-PA013197LA01HU)，的标记方式是Non-conjugated。对于LSAMP Antibody，我们还提供其他标记。见下表：

    可提供标记
    标记方式 货号 产品名称 应用
    HRP CSB-PA013197LB01HU LSAMP Antibody, HRP conjugated ELISA
    FITC CSB-PA013197LC01HU LSAMP Antibody, FITC conjugated
    Biotin CSB-PA013197LD01HU LSAMP Antibody, Biotin conjugated ELISA
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    >95%, Protein G purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, WB, IF
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:500-1:5000
    IF 1:50-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Mediates selective neuronal growth and axon targeting. Contributes to the guidance of developing axons and remodeling of mature circuits in the limbic system. Essential for normal growth of the hyppocampal mossy fiber projection.
  • 基因功能参考文献：
    1. We detected African-specific SNPs at ZNF649 and LSAMP, with associations of genome-wide significance for ulcerative colitis. PMID: 27693347
    2. A novel genomic alteration of LSAMP associates with aggressive prostate cancer in African American men PMID: 26844274
    3. The results showed significant allelic and haplotypic associations between LSAMP gene and schizophrenia. PMID: 24491686
    4. The tumor suppressor function of LSAMP is most likely exerted by reducing the proliferation rate of the tumor cells, possibly by indirectly upregulating one or more of the genes HES1, CTAG2 or KLF10. PMID: 24885297
    5. This study presents the first evidence of a possible role of LSAMP gene in mood and anxiety disorders in humans. PMID: 22892717
    6. proteomic assessments of membrane microdomains in prefrontal cortex and validation in two brain series, strongly implicates LAMP, STXBP1 and BASP1 in schizophreina and supports the view of a neuritic and synaptic dysfunction in the neuropathology PMID: 18268500
    7. Single nucleotide polymorphisms of LSAMP is associated with the pathogenesis of coronary artery disease. PMID: 18318786
    8. LSAMP might play a role in pathoaetiology of suicidal behaviour but further studies are needed to understand its exact contribution PMID: 18433483
    9. results show that LSAMP is a novel candidate tumor suppressor gene in osteosarcomas PMID: 19441093
    10. Identification of chromosomal aberrations associated with disease progression and a novel 3q13.31 deletion involving LSAMP gene in osteosarcoma. PMID: 19724913

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  • 亚细胞定位：
    Cell membrane; Lipid-anchor, GPI-anchor.
  • 蛋白家族：
    Immunoglobulin superfamily, IgLON family
  • 组织特异性：
    Expressed on limbic neurons and fiber tracts as well as in single layers of the superior colliculus, spinal chord and cerebellum.
  • 数据库链接：

    HGNC: 6705

    OMIM: 603241

    KEGG: hsa:4045

    UniGene: Hs.26409