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  4. LPHN3 Antibody

LPHN3 Antibody

  • 货号：
    CSB-PA013061GA01HU
  • 规格：
    ￥3,900
  • 其他：

产品详情

  • Uniprot No.：
    Q9HAR2
  • 基因名：
  • 别名：
    ADGRL3 antibody; Adhesion G protein coupled receptor L3 antibody; Calcium independent alpha latrotoxin receptor 3 antibody; Calcium-independent alpha-latrotoxin receptor 3 antibody; CIRL 3 antibody; CIRL-3 antibody; CIRL3 antibody; CL3 antibody; cl3 latrotoxin receptor antibody; KIAA0768 antibody; Latrophilin 3 antibody; Latrophilin homolog 3 (cow) antibody; Latrophilin homolog 3 antibody; Latrophilin-3 antibody; Latrophilin3 antibody; LEC 3 antibody; LEC3 antibody; Lectomedin 3 antibody; Lectomedin-3 antibody; Lectomedin3 antibody; lph3 antibody; LPHN 3 antibody; Lphn3 antibody; LPHN3_HUMAN antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse,Rat
  • 免疫原：
    Human LPHN3
  • 免疫原种属：
    Homo sapiens (Human)
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen Affinity purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,WB
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Plays a role in cell-cell adhesion and neuron guidance via its interactions with FLRT2 and FLRT3 that are expressed at the surface of adjacent cells. Plays a role in the development of glutamatergic synapses in the cortex. Important in determining the connectivity rates between the principal neurons in the cortex.
  • 基因功能参考文献：
    1. An ultraconserved brain-specific enhancer within LPHN3 is associated with ADHD susceptibility. PMID: 27692237
    2. Associations between LPHN1 and LPHN3 polymorphisms and severity of bronchial hyper-responsiveness in asthmatics were conducted; however, no associations were found. PMID: 27325752
    3. Results suggest that UNC5 and LPHN3 can simultaneously bind to FLRT3, forming a trimeric complex, and that FLRT3 may form transsynaptic complexes with both LPHN3 and UNC5. PMID: 26235030
    4. LPHN3 confers ADHD susceptibility, and moderates methylphenidate treatment response in children and adolescents with ADHD. PMID: 25989180
    5. Study examined the association between the LPHN3 rs6551665 A/G polymorphism and Attention deficit hyperactivity disorder (ADHD) in Korea; samples used in the study consisted of 150 ADHD children and 322 controls; ADHD children appeared to have a surplus of GG genotype, studies with larger sample sizes needed. PMID: 25871512
    6. genetic association studies in Germany: Data suggest that, within a sample of patients with attention deficit disorder hyperactivity, SNPs in LPHN3 gene impacts behavioral and neurophysiological measures of cognitive response control. PMID: 23245769
    7. Increased LPHN3 mRNA expression levels correlated with axillary-node metastasis in breast cancer. PMID: 23317273
    8. The influence of LPHN3 genotype on attention deficit-hyperactivity disorder (ADHD) and addiction is mediated through alterations in transgenic monoamine signaling. PMID: 22575564
    9. A two-locus genetic interaction between LPHN3 and 11q predicts ADHD severity and long-term outcome. PMID: 22832519
    10. This study identifying loci for aADHD and led to the identification of LPHN3 as novel genes associated with ADHD across the lifespan. PMID: 22105624
    11. highly significant interaction between four SNPs and maternal stress during pregnancy and development of attention-deficit/hyperactivity disorder PMID: 22486528
    12. single-nucleotide polymorphisms harbored in the LPHN3 gene interact with SNPs spanning the 11q region that contains DRD2 and NCAM1 genes, to double the risk of developing ADHD. PMID: 21606926
    13. This study demonistrated that LPHN3 and its ligand FLRT3 play an important role in glutamatergic synapse development. PMID: 22405201
    14. LPHN3, a new gene in which variants have recently been shown to be associated with adhd. PMID: 21432600
    15. These results further support the LPHN3 contribution to combined type ADHD, and specifically to the persistent form of the disorder PMID: 21040458
    16. The mutational analysis of the entire coding region of LPHN3 in a cohort of 139 attention deficit hyperactivity disorder subjects and 52 controls, is reported. PMID: 21184580

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  • 亚细胞定位：
    Cell membrane; Multi-pass membrane protein. Cell projection, axon. Cell junction.
  • 蛋白家族：
    G-protein coupled receptor 2 family, LN-TM7 subfamily
  • 数据库链接：

    HGNC: 20974

    OMIM: 616417

    KEGG: hsa:23284

    STRING: 9606.ENSP00000422533

    UniGene: Hs.28391