Your Good Partner in Biology Research

  1. Home
  2. 抗体
  3. 多克隆抗体
  4. LPCAT1 Antibody

LPCAT1 Antibody

  • 货号：
    CSB-PA013052GA01HU
  • 规格：
    ￥3,900
  • 其他：

产品详情

  • Uniprot No.：
    Q8NF37
  • 基因名：
    LPCAT1
  • 别名：
    1 acylglycerophosphocholine O acyltransferase antibody; 1 alkylglycerophosphocholine O acetyltransferase antibody; 1-acylglycerophosphocholine O-acyltransferase antibody; 1-alkylglycerophosphocholine O-acetyltransferase antibody; Acetyl CoA:lyso PAF acetyltransferase antibody; Acetyl CoA:lyso platelet activating factor acetyltransferase antibody; Acetyl-CoA:lyso-PAF acetyltransferase antibody; Acetyl-CoA:lyso-platelet-activating factor acetyltransferase antibody; Acyl CoA:lysophosphatidylcholine acyltransferase 1 antibody; Acyltransferase like 2 antibody; Acyltransferase-like 2 antibody; AGPAT10 antibody; AGPAT9 antibody; AYTL1 antibody; AYTL2 antibody; FLJ12443 antibody; FLJ41609 antibody; LPC acyltransferase 1 antibody; LPC acyltransferase antibody; lpcat antibody; LPCAT-1 antibody; LPCAT1 antibody; Lyso PAF acetyltransferase antibody; Lyso-PAF acetyltransferase antibody; LysoPAFAT antibody; LysoPC acyltransferase 1 antibody; Lysophosphatidylcholine acyltransferase 1 antibody; PCAT1_HUMAN antibody; PFAAP3 antibody; Phosphonoformate immuno associated protein 3 antibody; Phosphonoformate immuno-associated protein 3 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse,Rat
  • 免疫原：
    Human LPCAT1
  • 免疫原种属：
    Homo sapiens (Human)
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen Affinity purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,WB,IHC,IF
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Exhibits acyltransferase activity. Exhibits acetyltransferase activity. Activity is calcium-independent. Catalyzes the conversion of lysophosphatidylcholine (1-acyl-sn-glycero-3-phosphocholine or LPC) into phosphatidylcholine (1,2-diacyl-sn-glycero-3-phosphocholine or PC). Catalyzes the conversion 1-acyl-sn-glycerol-3-phosphate (lysophosphatidic acid or LPA) into 1,2-diacyl-sn-glycerol-3-phosphate (phosphatidic acid or PA) by incorporating an acyl moiety at the sn-2 position of the glycerol backbone. Displays a clear preference for saturated fatty acyl-CoAs, and 1-myristoyl or 1-palmitoyl LPC as acyl donors and acceptors, respectively. Involved in platelet-activating factor (PAF) biosynthesis by catalyzing the conversion of the PAF precursor, 1-O-alkyl-sn-glycero-3-phosphocholine (lyso-PAF) into 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine (PAF). May synthesize phosphatidylcholine in pulmonary surfactant, thereby playing a pivotal role in respiratory physiology. Involved in the regulation of lipid droplet number and size.
  • 基因功能参考文献：
    1. fetal LPCAT1 mRNA present in maternal blood in quantity that correlates with lamellar body count PMID: 28926341
    2. The overexpression of LPCAT1 promotes the development and progression of ccRCC, likely through the conversion of LPC to PC. PMID: 28494778
    3. We found a direct correlation between LPCAT1 mRNA copies and the amniotic fluid lamellar body count. This finding corroborates an association between LPCAT1 and surfactant phospholipid biosynthesis. PMID: 25968427
    4. Overexpression of Lysophosphatidylcholine Acyltransferase 1 and Concomitant Lipid Alterations are associated with Gastric Cancer PMID: 25752890
    5. No disease causing mutations in the LPCAT1 gene were identified, indicating that LPCAT1 either does not confer a genetic predisposition to retinitis pigmentosa, or incidence of mutations in LPCAT1 is particularly rare in patients with retinitis pigmentosa. PMID: 26260533
    6. Down-regulation of LPCAT1 resulted in a decreased intercellular platelet-activating factor concentration and PAFR expression. PMID: 25803864
    7. LPCAT1 is an independent predictor of early tumor recurrence of breast carcinoma and represents a novel prognostic biomarker that reflects underlying biological alterations PMID: 25683484
    8. LPCAT1, a gene involved in the remodeling of phospholipids, was nominally associated with incident SCA risk. PMID: 24418166
    9. The prognostic impact of LPCAT1 expression was independent of histological and clinical parameters. It is concluded, that LPCAT1 measurement, either alone or in combination, may be utilized for better clinical decision-making. PMID: 23941784
    10. effect of LPCAT1 overexpression or knockdown on cell proliferation, migration, and invasion in hepatocellular carcinoma cell lines PMID: 23567080
    11. LPCAT1 correlates with the progression of prostate cancer. PMID: 22101258
    12. full LPCAT1 activity is required to achieve the levels of SatPC essential for the transition to air breathing PMID: 20407208
    13. hLPCAT1 is the biosynthetic enzyme of pulmonary surfactant phospholipids. PMID: 19383981
    14. Aytl2 gene is the phosphatidylcholine reacylating enzyme in RBCs; this represents the identification of a plasma membrane lysophospholipid acyltransferase and establishes the function of a LPCAT protein PMID: 18156367
    15. LPCAT1 may contribute to total choline metabolite accumulation via phosphatidylcholine remodeling, thereby altering the CRC lipid profile, a characteristic of malignancy. PMID: 18974965

    显示更多

    收起更多

  • 亚细胞定位：
    Endoplasmic reticulum membrane; Single-pass type II membrane protein. Golgi apparatus membrane; Single-pass type II membrane protein. Cell membrane; Single-pass type II membrane protein. Lipid droplet.
  • 蛋白家族：
    1-acyl-sn-glycerol-3-phosphate acyltransferase family
  • 组织特异性：
    Erythrocytes.
  • 数据库链接：

    HGNC: 25718

    OMIM: 610472

    KEGG: hsa:79888

    STRING: 9606.ENSP00000283415

    UniGene: Hs.368853