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  4. LMO4 Antibody

LMO4 Antibody

  • 货号：
    CSB-PA013011ESR2HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Immunohistochemistry of paraffin-embedded human prostate cancer using CSB-PA013011ESR2HU at dilution of 1:100
    • Immunohistochemistry of paraffin-embedded human colon cancer using CSB-PA013011ESR2HU at dilution of 1:100
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) LMO4 Polyclonal antibody
  • Uniprot No.：
    P61968
  • 基因名：
    LMO4
  • 别名：
    Breast tumor autoantigen antibody; LIM domain only 4 antibody; LIM domain only protein 4 antibody; LIM domain transcription factor LMO 4 antibody; LIM domain transcription factor LMO4 antibody; LMO 4 antibody; LMO-4 antibody; LMO4 antibody; LMO4_HUMAN antibody; OTTHUMP00000011905 antibody; OTTHUMP00000011906 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Recombinant Human LIM domain transcription factor LMO4 protein (1-165AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen Affinity Purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, IHC
  • 推荐稀释比：
    Application Recommended Dilution
    IHC 1:20-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Probable transcriptional factor.
  • 基因功能参考文献：
    1. Lmo4 participates in the regulation of lung epithelial cell proliferation but is not essential for tumor progression. PMID: 26048572
    2. LMO4 appears to form a hub in protein-protein interaction networks, linking numerous pathways within cells. PMID: 25310299
    3. Clim2, in a complex with LMO4, supports mammary stem cells by directly targeting the Fgfr2 promoter in basal cells to increase its expression PMID: 25079073
    4. Existence of a region in the lateral portion of the mammalian cochlea that is competent to make an organ of Corti is demonstrated in the absence of LMO4 function. PMID: 25057208
    5. Low LMO4 mRNA levels were associated with response to erlotinib in non-small-cell lung cancer. PMID: 23407556
    6. oncoprotein HBXIP is able to activate the transcriptional coregulatory protein LMO4 through transcription factor Sp1 in promotion of proliferation of breast cancer cells. PMID: 23291272
    7. Data suggest that overexpression of LMO4 may disrupt some of the normal tumour suppressor activities of CtIP, thereby contributing to breast cancer progression. PMID: 23353824
    8. the association of high levels of LMO4 with aggressive neuroblastomas is dependent on LMO4 regulation of cadherin expression and hence, tumor invasiveness PMID: 23407937
    9. LMO4 is a direct target of p53 and inhibits p53-mediated proliferative inhibition of breast cancer cells through interacting p53 PMID: 22906635
    10. LMO4 is over-expressed in highly invasive rhabdomyosarcoma, alveolar cells PMID: 21271214
    11. LMO4 expression in squamous cell carcinoma of the anterior tongue PMID: 21362019
    12. data indicate that LMO4 has similar cellular effects in normal mammary epithelial cells and breast cancer cells, and also provide direct evidence for the idea that normal development and carcinogenesis share conserved molecular mechanisms PMID: 20526802
    13. LMO4 protects neurons from ischemic brain injury, in part through its requirement as an essential cofactor of PPAR gamma PMID: 19020036
    14. These findings reveal a novel complex between BRCA1, LMO4, and CtIP and indicate a role for LMO4 as a repressor of BRCA1 activity in breast tissue. PMID: 11751867
    15. 1H, 15N and 13C assignments of FLIN4, an intramolecular LMO4:ldb1 complex PMID: 12153047
    16. Lmo4 RNA overexpression interferes with neuritic outgrowth,anti-sense Lmo4 RNA expression favors neuritogenesis in SH-SY5Y cells. Changes in Lmo4 RNA expression levels might alter the rate of neuritic outgrowth in the developing and adult nervous system. PMID: 12877980
    17. LMO4 interaction modulates the interleukin-6 receptor subunit glycoprotein 130 complex and its signaling PMID: 15677447
    18. LMO4 is consistently more highly expressed in the embryonic right perisylvian cerebral cortex than in the left PMID: 15894532
    19. LMO4 in breast epithelium contributes directly to breast neoplasia by altering the rate of cellular proliferation and promoting cell invasion. PMID: 15897450
    20. Artificial intramolecular cyclic protein complex between two interacting proteins: the largely unstable LIM-only protein 4 (LMO4) and an unstructured domain of LIM domain binding protein 1 (ldb1). PMID: 17001033
    21. In this study, patients whose tumours exhibited high LMO4 expression had a significant survival advantage following operative resection PMID: 18231110
    22. Results suggested that LMO4 is overexpressed at late stages in carcinogenesis of pancreatic cancer. PMID: 19099607
    23. Lmo4 expression coincides with the timing of the development of the somatosensory barrel field. PMID: 19111533
    24. LMO4 is a novel cell cycle regulator with a key role in mediating ErbB2-induced proliferation, a hallmark of ErbB2-positive disease. PMID: 19648968

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  • 数据库链接：

    HGNC: 6644

    OMIM: 603129

    KEGG: hsa:8543

    STRING: 9606.ENSP00000359573

    UniGene: Hs.436792