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LMNB2 Antibody

  • 货号：
    CSB-PA013005LA01HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Immunohistochemistry of paraffin-embedded human glioma using CSB-PA013005LA01HU at dilution of 1:100
    • Immunofluorescent analysis of HepG2 cells using CSB-PA013005LA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) LMNB2 Polyclonal antibody
  • Uniprot No.：
    Q03252
  • 基因名：
  • 别名：
    LAMB 2 antibody; LAMB2 antibody; Lamin-B2 antibody; LMN 2 antibody; LMN B2 antibody; LMN2 antibody; LMNB 2 antibody; LMNB2 antibody; LMNB2_HUMAN antibody; MGC2721 antibody; RGD1563803 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Recombinant Human Lamin-B2 protein (442-615AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated

    本页面中的产品，LMNB2 Antibody (CSB-PA013005LA01HU)，的标记方式是Non-conjugated。对于LMNB2 Antibody，我们还提供其他标记。见下表：

    可提供标记
    标记方式 货号 产品名称 应用
    HRP CSB-PA013005LB01HU LMNB2 Antibody, HRP conjugated ELISA
    FITC CSB-PA013005LC01HU LMNB2 Antibody, FITC conjugated
    Biotin CSB-PA013005LD01HU LMNB2 Antibody, Biotin conjugated ELISA
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    >95%, Protein G purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, IHC, IF
  • 推荐稀释比：
    Application Recommended Dilution
    IHC 1:20-1:200
    IF 1:50-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Lamins are components of the nuclear lamina, a fibrous layer on the nucleoplasmic side of the inner nuclear membrane, which is thought to provide a framework for the nuclear envelope and may also interact with chromatin.
  • 基因功能参考文献：
    1. our studies strongly implicate an overarching role for Lamin B2 in the maintenance of nuclear architecture since loss of Lamin B2 relieves the spatial positional constraints required for maintaining conserved localization of aneuploid chromosome territories in the interphase nucleus. PMID: 26921073
    2. Mutation of the nuclear lamin gene LMNB2 in progressive myoclonus epilepsy with early ataxia. PMID: 25954030
    3. Nuclear envelope remodelling during human spermiogenesis involves somatic B-type lamins and a spermatid-specific B3 lamin isoform. PMID: 25477337
    4. Treating normal human fibroblasts with farnesyltransferase inhibitors causes the accumulation of unprocessed lamin B2 and lamin A and a decrease in mature lamin B1 PMID: 23475125
    5. Mutation in LMNB2 gene is associated with partial lipodystrophy. PMID: 22768673
    6. Studies indicate that the lamin-binding proteins implicated in laminopathies include lamin B2 and nuclear envelope proteins. PMID: 21400569
    7. These findings indicate that a lamin dimer principally has the freedom for a "combinatorial" head-to-tail association with all types of lamins, a property that might be of significant importance for the assembly of the nuclear lamina. PMID: 20004208
    8. analysis of protein-DNA interactions at the human lamin B2 replication origin PMID: 12902329
    9. The proteins bound in vivo at the LMNB2 replication origin were investigated along the cell cycle. PMID: 12912926
    10. This analysis reveals the modular structure of the lamin B2 origin and supports the idea that sequence elements close to the replication start site play an important role in origin activation. PMID: 15024083
    11. the distinctive ensemble of heterotypic lamin interactions in a particular cell type affects the stability of the lamin polymer PMID: 15284226
    12. the lamin B2 origin adopts a structure partly composed of intramolecular TAT triads PMID: 15611042
    13. lamin B was essential for the formation of the mitotic matrix that tethers a number of spindle assembly factors; propose that lamin B is a structural component of the spindle matrix that promotes microtubule assembly and organization in mitosis PMID: 16543417
    14. Three new rare heterozygous mutations are the first reported for LMNB2 and are the first reported among patients with acquired partial lipodystrophy. PMID: 16826530
    15. human lamin B(2) is indeed synthesized as a longer version than previously reported, because it contains these additional 20 amino acids PMID: 17070523
    16. The human DNA replication origin, located in the lamin B2 gene, interacts with the DNA topoisomerases I and II in a cell cycle-modulated manner. PMID: 17290216

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  • 相关疾病：
    Partial acquired lipodystrophy (APLD); Epilepsy, progressive myoclonic 9 (EPM9)
  • 亚细胞定位：
    Nucleus inner membrane; Lipid-anchor; Nucleoplasmic side.
  • 蛋白家族：
    Intermediate filament family
  • 数据库链接：

    HGNC: 6638

    OMIM: 150341

    KEGG: hsa:84823

    STRING: 9606.ENSP00000462730

    UniGene: Hs.538286