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LMAN2L Antibody

  • 货号：
    CSB-PA863945LA01HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) LMAN2L Polyclonal antibody
  • Uniprot No.：
    Q9H0V9
  • 基因名：
    LMAN2L
  • 别名：
    LMAN2L antibody; VIPL antibody; PSEC0028 antibody; UNQ368/PRO704 antibody; VIP36-like protein antibody; Lectin mannose-binding 2-like antibody; LMAN2-like protein antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Recombinant Human VIP36-like protein (45-313AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated

    本页面中的产品，LMAN2L Antibody (CSB-PA863945LA01HU)，的标记方式是Non-conjugated。对于LMAN2L Antibody，我们还提供其他标记。见下表：

    可提供标记
    标记方式 货号 产品名称 应用
    HRP CSB-PA863945LB01HU LMAN2L Antibody, HRP conjugated ELISA
    FITC CSB-PA863945LC01HU LMAN2L Antibody, FITC conjugated
    Biotin CSB-PA863945LD01HU LMAN2L Antibody, Biotin conjugated ELISA
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    >95%, Protein G purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    May be involved in the regulation of export from the endoplasmic reticulum of a subset of glycoproteins. May function as a regulator of ERGIC-53.
  • 基因功能参考文献：
    1. Homozygous missense mutation p.R53Q in the LMAN2L gene causes autosomal recessive intellectual disability and seizures. PMID: 26566883
    2. Study showed a significant association between LMAN2L and risk of both bipolar disorder and schizophrenia PMID: 24914473
    3. The results of this study suggested that significant novel association signals near the genes LMAN2L and provide supportive evidence for the previously reported association signals near ANK3 and within the 3p21.1 locus. PMID: 22182935
    4. VIPL terminates in the sequence KRFY, characteristic for proteins recycling between the ER and ERGIC/cis-Golgi; and knock-down of VIPL mRNA slowed secretion of two glycoproteins (35 and 250 kDa), suggesting that VIPL may function as an ER export receptor. PMID: 12878160
    5. selective interaction of VIPL and VIP36 with the deglucosylated trimannose in the D1 branch of high-mannose-type oligosaccharides but with different pH dependence. PMID: 18025080

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  • 相关疾病：
    Mental retardation, autosomal recessive 52 (MRT52)
  • 亚细胞定位：
    Endoplasmic reticulum membrane; Single-pass type I membrane protein. Golgi apparatus membrane; Single-pass type I membrane protein. Note=Predominantly found in the endoplasmic reticulum. Partly found in the Golgi.
  • 组织特异性：
    Expressed in numerous tissues. Highest expression in skeletal muscle and kidney, intermediate levels in heart, liver and placenta, low levels in brain, thymus, spleen, small intestine and lung.
  • 数据库链接：

    HGNC: 19263

    OMIM: 609552

    KEGG: hsa:81562

    STRING: 9606.ENSP00000366280

    UniGene: Hs.655743