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LHB Antibody

  • 货号：
    CSB-PA031640
  • 规格：
    ￥1100
  • 图片：
    • Gel: 10+12%SDS-PAGE, Lysate: 40 μg, Lane 1-2: 293T cells, Human fetal brain tissue, Primary antibody: CSB-PA031640(LHB Antibody) at dilution 1/250, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 5 minutes
  • 其他：

产品详情

  • Uniprot No.：
    P01229
  • 基因名：
    LHB
  • 别名：
    CGB4 antibody; CHORIONIC GONADOTROPIN; BETA POLYPEPTIDE 4 antibody; hLHB antibody; Interstitial cell stimulating hormone beta chain antibody; Leutropin antibody; LH-B antibody; LHB antibody; LSH beta antibody; LSH-B antibody; LSH-beta antibody; LSHB antibody; LSHB_HUMAN antibody; Luteinizing hormone beta polypeptide antibody; Luteinizing hormone subunit beta antibody; Lutropin beta chain antibody; Lutropin subunit beta antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Synthetic peptide of Human LHB
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen affinity purification
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,WB
  • 推荐稀释比：
    Application Recommended Dilution
    ELISA 1:1000-1:2000
    WB 1:200-1:1000
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Promotes spermatogenesis and ovulation by stimulating the testes and ovaries to synthesize steroids.
  • 基因功能参考文献：
    1. The rs34349826 and rs6521 loci of the LHB gene were not related to male infertility, which can be further confirmed by larger-sample studies. The GG genotype combination is a protective factor against male infertility. PMID: 30173455
    2. Homozygous nonsense mutation Trp28X in the LHB gene causes LH deficiency. PMID: 29476300
    3. A 20-year-old male from a consanguineous family had pubertal delay, hypogonadism and undetectable LH. A homozygous c.118_120del (p.Lys40del) mutation was identified in the patient and his brother, who subsequently had the same phenotype. PMID: 27656125
    4. In girls with central precocious puberty, increased body mass index (BMI) was associated with slightly lower peak stimulated luteinizing hormone (LH) levels at early pubertal stages (Tanner stages 2 and 3). PMID: 27215137
    5. LHbeta G1052A and LHCGR G935A genes polymorphisms are associated with increased risk of polycystic ovary syndrome in Egyptian women especially in obese cases. PMID: 26662070
    6. The Trp8Arg/Ile15Thr polymorphism within the LHB gene was not associated with endometriosis and infertility. PMID: 25935136
    7. This paper shows a conclusive contribution of Variant-Luteinizing hormone to the natural variance in male serum Luteinizing hormone levels PMID: 25820123
    8. the frequency of v-betaLH in Denmark is similar to a number of European countries PMID: 23725475
    9. LH, progesterone, and TSH can stimulate aldosterone. PMID: 24297486
    10. Data indicate a modulatory effect of luteinizing hormone beta-subunit (LHB) gene polymorphisms on hyperandrogenemia phenotype of Polycystic Ovary Syndrome (PCOS) was observed. PMID: 25111116
    11. No association was found between poor ovarian response to ovarian stimulation and variant-betaLH. PMID: 24625195
    12. Both estradiol and progesterone uniquely modulate basal and GnRH-stimulated gonadotropin promoters without affecting cell growth. PMID: 23160221
    13. FOXO1 transcription factor inhibits luteinizing hormone beta gene expression in pituitary gonadotrope cells PMID: 22865884
    14. Results suggested LH G1052A mutation might influence polycystic ovary syndrome susceptibility and phenotypes. PMID: 22546001
    15. Polymorphisms of Trp8Arg and Ile15Thr in the LH-beta subunit gene occur in infertile women. PMID: 22108961
    16. We identified seven SNPs in the LH beta gene; one SNP in exon 3 (rs#1056917) exhibited significant difference in the allele frequency between the PCOS cases and controls PMID: 22209983
    17. the presence of LHbeta G1502A and ERbeta G+1730A polymorphisms is associated with infertility and endometriosis associated infertility.When two polymorphisms are present it does not appear to increase the chance of developing endometriosis or infertility. PMID: 21764500
    18. Both normal-weight and overweight women with classic PCOS phenotypes present higher LH levels and LH-to-FSH ratios than women with similar BMI but the newer phenotypes. PMID: 21353371
    19. A dileucine determinant in the carboxyl terminal sequence of the luteinizing hormone beta subunit is implicated in the regulated secretion of lutropin PMID: 21458524
    20. Variant LH remains longer in circulation than wild type during GnRH receptor blockade in heterozygous women, in accord with its higher content of sialic acid. PMID: 19890021
    21. relationship between endometriosis and a variant of the beta-subunit of luteinizing hormone PMID: 12042273
    22. findings demonstrate that Gly(102)Ser mutation of the LHbeta gene does not affect receptor binding and bioactivity of the hormone, when tested in vitro PMID: 12356936
    23. Results suggest that a single nucleotide polymorphism alters the post-translational modification of luteinizing hormone beta and hence its structural phenotype. PMID: 12683946
    24. MIP-2A (MBP-1 interacting protein-2A) preferentially expresses in certain tissues, including the pituitary gland, and negatively regulates the LHbeta gene transcription PMID: 12700240
    25. genetically determined variation in LH function might affect susceptibility to prostate cancer via altered testosterone secretion. PMID: 12746844
    26. pituitary exit of LH and FSH occur via different secretion pathways, and are released spatially from the pituitary via different circulatory routes. PMID: 14585810
    27. LH modulates the processing of amyloid-beta precursor protein and amyloid-beta deposition PMID: 14871891
    28. LHbeta-null mice are viable but demonstrate postnatal defects in gonadal growth and function resulting in infertility. PMID: 15569941
    29. The tight linkage between the two missense substitutions in the coding region and the eight nucleotide substitutions in the promoter region of LHB appears to be common to various ethnic groups. PMID: 16410673
    30. homozygous mutation of a 5' splice site in LHB: IVS2+1G-->C disrupts the splicing of messenger RNA, generating a gross abnormality in the processing of the luteinizing hormone beta-subunit mRNA, which abrogates the secretion of luteinizing hormone PMID: 17761593
    31. GnRH stimulation of signaling pathway for annexin A5 mRNA expression is distinct from that of LHbeta mRNA and dependent more on MAPK. PMID: 18703851
    32. Progesterone feedback at the level of the pituitary gonadotrope is likely to play a key role in differential production of the gonadotropin genes. PMID: 19106225
    33. Inactivating mutations of luteinizing hormone beta-subunit or luteinizing hormone receptor cause oligo-amenorrhea and infertility in women. PMID: 19129711
    34. v-betaLH is more frequent in women with ovarian resistance to rhFSH. PMID: 19146763

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  • 相关疾病：
    Hypogonadotropic hypogonadism 23 without anosmia (HH23)
  • 亚细胞定位：
    Secreted.
  • 蛋白家族：
    Glycoprotein hormones subunit beta family
  • 组织特异性：
    Pituitary gland.
  • 数据库链接：

    HGNC: 6584

    OMIM: 152780

    KEGG: hsa:3972

    STRING: 9606.ENSP00000221421

    UniGene: Hs.154704