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LDOC1 Antibody

  • 货号：
    CSB-PA008425
  • 规格：
    ￥880
  • 其他：

产品详情

  • Uniprot No.：
    O95751
  • 基因名：
    LDOC1
  • 别名：
    BCUR1 antibody; Breast cancer up regulated 1 antibody; Breast cancer upregulated 1 antibody; Gm366 antibody; Ldoc1 antibody; LDOC1_HUMAN antibody; Leucine zipper down regulated in cancer 1 antibody; Leucine zipper protein down regulated in cancer cells antibody; Leucine zipper protein down regulated in cancer cells antibody; Leucine zipper protein down-regulated in cancer cells antibody; Mar7 antibody; Mart7 antibody; Protein LDOC1 antibody; RGD1565644 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse
  • 免疫原：
    Synthesized peptide derived from the Internal region of Human LDOC1.
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 抗体亚型：
    IgG
  • 纯化方式：
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 产品提供形式：
    Liquid
  • 应用范围：
    IHC, ELISA
  • 推荐稀释比：
    Application Recommended Dilution
    IHC 1:100-1:300
    ELISA 1:5000
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    May have an important role in the development and/or progression of some cancers.
  • 基因功能参考文献：
    1. that epigenetic silencing of LDOC1 in high-risk Group A ependymoma regulates tumor biology and drives inflammatory immune phenotype PMID: 28510691
    2. GNL3L-LDOC1 interplay regulates cell proliferation through the modulation of NF-kappaB pathway during tumorigenesis. PMID: 27764577
    3. These finding of this study suggested that the hypothesize that LDOC1 gene upregulation may play a role in the spermatogenesis derangement observed in patients with Klinefelter Syndrome. PMID: 27076087
    4. data show that LDOC1 is a tumor suppressor in osteosarcoma, and that it regulates metastasis of osteosarcoma cells. Furthermore, LDOC1 might be a valuable prognostic marker in osteosarcomas. PMID: 28240050
    5. Cigarette smoke-induced promoter methylation may contribute to LDOC1 downregulation, thereby conferring oncogenic features to oral cells. PMID: 26317789
    6. LDOC1 inhibits proliferation and promotes apoptosis by repressing NF-kappaB activation in papillary thyroid carcinoma PMID: 26637328
    7. It has potential roles in apoptosis of well differentiated carcinoma without metastases and in neurodegeneration of Alzheimer's disease. PMID: 23775301
    8. Silencing of LDOC1 is a frequent event in cervical cancer and may be of interest as a molecular marker in cervical cancer. PMID: 24125169
    9. Silencing of BEX1 and LDOC1 by promoter hypermethylation might represent a critical event in the molecular pathogenesis of oral squamous cell carcinoma (OSCC) and the male predominance of OSCC occurrence. PMID: 23362108
    10. Letter/Case Report: LDOC1/PARP1 are down-regulated in melanoma with repeated in-transit metastases. PMID: 21986234
    11. The aim of this study was to evaluate the possible differential expression of LDOC1 mRNA in leucocytes of peripheral blood of Down's syndrome subjects. compared with the normal population. PMID: 22546831
    12. Over expression of LDOC1 may explain the clinical manifestation found in patients with cryptochidism and Digeorge anomaly. PMID: 21547351
    13. LDOC1 is dramatically down-regulated in mutated chronic lymphocytic leukemia cases compared with unmutated cases, and have identified a new splice variant, LDOC1S PMID: 21310924
    14. These observations suggest that LDOC1 is a novel regulator of NF-kappaB that can affect the PMA or TNF-alpha-mediated pathway to apoptosis through inhibition of NF-kappaB activation in BxPC3 pancreatic cancer cells. PMID: 12712434
    15. MZF-1 was revealed to interact with LDOC1 and enhance the activity of LDOC1 for inducing apoptosis PMID: 15670815

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  • 亚细胞定位：
    Nucleus.
  • 蛋白家族：
    LDOC1 family
  • 组织特异性：
    Ubiquitously expressed with high levels in brain ant thyroid and low expression in placenta, liver and leukocytes. Expressed as well in six of the seven human breast cancer cell lines examined.
  • 数据库链接：

    HGNC: 6548

    OMIM: 300402

    KEGG: hsa:23641

    STRING: 9606.ENSP00000359557

    UniGene: Hs.45231