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LCMT1 Antibody

  • 中文名称：
    LCMT1兔多克隆抗体
  • 货号：
    CSB-PA012808LA01HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Western Blot
      Positive WB detected in: HepG2 whole cell lysate, NTERA-2 whole cell lysate
      All lanes: LCMT1 antibody at 1:2000
      Secondary
      Goat polyclonal to rabbit IgG at 1/50000 dilution
      Predicted band size: 39, 42, 33 kDa
      Observed band size: 39 kDa
    • Immunofluorescence staining of A549 cells with CSB-PA012808LA01HU-IF at 1:100, counter-stained with DAPI. The cells were fixed in 4% formaldehyde and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) LCMT1 Polyclonal antibody
  • Uniprot No.：
    Q9UIC8
  • 基因名：
    LCMT1
  • 别名：
    Leucine carboxyl methyltransferase 1 (EC 2.1.1.233) (Protein-leucine O-methyltransferase) ([Phosphatase 2A protein]-leucine-carboxy methyltransferase 1), LCMT1, LCMT
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Recombinant Human Leucine carboxyl methyltransferase 1 protein (157-357aa)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated

    本页面中的产品，LCMT1 Antibody (CSB-PA012808LA01HU)，的标记方式是Non-conjugated。对于LCMT1 Antibody，我们还提供其他标记。见下表：

    可提供标记
    标记方式 货号 产品名称 应用
    HRP CSB-PA012808LB01HU LCMT1 Antibody, HRP conjugated ELISA
    FITC CSB-PA012808LC01HU LCMT1 Antibody, FITC conjugated
    Biotin CSB-PA012808LD01HU LCMT1 Antibody, Biotin conjugated ELISA
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    >95%, Protein G purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, WB, IF
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:1000-1:5000
    IF 1:100-1:500
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Methylates the carboxyl group of the C-terminal leucine residue of protein phosphatase 2A catalytic subunits to form alpha-leucine ester residues.
  • 基因功能参考文献：
    1. alterations in the membrane localization of PP2A and Tau following down-regulation of LCMT1 may lead to PP2A and Tau dysfunction in AD. PMID: 23943618
    2. determined crystal structures of human LCMT-1 in isolation and in complex with PP2A stabilized by a cofactor mimic. The structures show that the LCMT-1 active-site pocket recognizes the carboxyl terminus of PP2A PMID: 21292165
    3. X-ray crystal structure of human LCMT1 protein in complex with the cofactor S-adenosylmethionine (AdoMet) has been solved to a resolution of 2 A. PMID: 21206058
    4. LCMT-1 is important for normal progression through mitosis and cell survival and is essential for embryonic development PMID: 17724024
  • 蛋白家族：
    Methyltransferase superfamily, LCMT family
  • 数据库链接：

    HGNC: 17557

    OMIM: 610286

    KEGG: hsa:51451

    STRING: 9606.ENSP00000382021

    UniGene: Hs.337730