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  4. LARP1 Antibody

LARP1 Antibody

  • 货号：
    CSB-PA012750GA01HU
  • 规格：
    ￥3,900
  • 其他：

产品详情

  • Uniprot No.：
    Q6PKG0
  • 基因名：
  • 别名：
    LARP1 antibody; KIAA0731 antibody; LARP antibody; La-related protein 1 antibody; La ribonucleoprotein domain family member 1 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse,Rat
  • 免疫原：
    Human LARP1
  • 免疫原种属：
    Homo sapiens (Human)
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen Affinity Purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,WB
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    RNA-binding protein that regulates the translation of specific target mRNA species downstream of the mTORC1 complex, in function of growth signals and nutrient availability. Interacts on the one hand with the 3' poly-A tails that are present in all mRNA molecules, and on the other hand with the 7-methylguanosine cap structure of mRNAs containing a 5' terminal oligopyrimidine (5'TOP) motif, which is present in mRNAs encoding ribosomal proteins and several components of the translation machinery. The interaction with the 5' end of mRNAs containing a 5'TOP motif leads to translational repression by preventing the binding of EIF4G1. When mTORC1 is activated, LARP1 is phosphorylated and dissociates from the 5' untranslated region (UTR) of mRNA. Does not prevent binding of EIF4G1 to mRNAs that lack a 5'TOP motif. Interacts with the free 40S ribosome subunit and with ribosomes, both monosomes and polysomes. Under normal nutrient availability, interacts primarily with the 3' untranslated region (UTR) of mRNAs encoding ribosomal proteins and increases protein synthesis. Associates with actively translating ribosomes and stimulates translation of mRNAs containing a 5'TOP motif, thereby regulating protein synthesis, and as a consequence, cell growth and proliferation. Stabilizes mRNAs species with a 5'TOP motif, which is required to prevent apoptosis.; (Microbial infection) Positively regulates the replication of dengue virus (DENV).
  • 基因功能参考文献：
    1. we suggest that the dysfunction of the XIST/miR-374a/LARP1 axis contributes to non-small cell lung cancer (NSCLC)and may serve as a promising therapeutic strategy for treatment. PMID: 29039571
    2. Thus, in response to cellular mTOR activity, LARP1 serves as a phosphorylation-sensitive molecular switch for turning off or on ribosomal protein mRNA translation and subsequent ribosome biogenesis. PMID: 28650797
    3. A cytoplasmic isoform of La protein as well as LARPs 6, 4, and 1 function in mRNA metabolism and translation in distinct but similar ways, sometimes with the poly(A)-binding protein, and in some cases by direct binding to poly(A)-RNA. PMID: 28782243
    4. The s show that LARP1 directly binds the cap and adjacent 5'TOP motif of TOP mRNAs, effectively impeding access of eIF4E to the cap and preventing eIF4F assembly. Thus, LARP1 is a specialized TOP mRNA cap-binding protein that controls ribosome biogenesis. PMID: 28379136
    5. LARP1 plays an important role in the proliferation of colorectal cancer and represents a new prognostic indicator. PMID: 27614686
    6. Data indicate that RNA-binding protein LARP1 promotes ovarian cancer progression and chemotherapy resistance. PMID: 26717985
    7. Data showed that LARP1 was upregulated in prostate cancer (PCa) and contributed to cancer cell invasion, indicating that it functioned as an oncogene. Its 3'UTR is the binding site for miR-26a and miR-26b. PMID: 26063484
    8. The first evidence that the DM15 region of human LARP1 mediates its RNA binding activity. PMID: 26206669
    9. conclude that, through the post-transcriptional regulation of genes such as mTOR within cancer pathways, LARP1 contributes to cancer progression PMID: 25531318
    10. LARP1 is a target of mTORC1 that associates with TOP mRNAs via their 5'TOP motif to repress their translation. PMID: 25940091
    11. LARP1 associates with actively translating ribosomes via PABP and that LARP1 stimulates the translation of mRNAs containing a 5' terminal oligopyrimidine (TOP) motif PMID: 24532714
    12. LARP1 may be involved in the post-transcriptional regulation of gene expression through the binding to 3' terminus of the poly(A) tail. PMID: 23711370
    13. Nuclear trafficking of La protein depends on a newly identified nucleolar localization signal and the ability to bind RNA PMID: 15060081

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  • 亚细胞定位：
    Cytoplasm. Cytoplasmic granule.
  • 蛋白家族：
    LARP family
  • 数据库链接：

    HGNC: 29531

    OMIM: 612059

    KEGG: hsa:23367

    STRING: 9606.ENSP00000336721

    UniGene: Hs.292078