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LAMC3 Antibody

  • 货号：
    CSB-PA006484
  • 规格：
    ￥880
  • 图片：
    • Western Blot analysis of SH-SY5Y cells using Laminin γ-3 Polyclonal Antibody
  • 其他：

产品详情

  • Uniprot No.：
    Q9Y6N6
  • 基因名：
  • 别名：
    LAMA 1 antibody; LAMA antibody; LAMA1 antibody; LAMB1 antibody; Lamc3 antibody; LAMC3_HUMAN antibody; Laminin A chain antibody; Laminin alpha 1 antibody; Laminin alpha 1 chain antibody; Laminin B1 chain antibody; Laminin subunit beta 1 antibody; Laminin subunit gamma-3 antibody; Laminin-12 subunit gamma antibody; Laminin-14 subunit gamma antibody; Laminin-15 subunit gamma antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse
  • 免疫原：
    Synthesized peptide derived from the C-terminal region of Human Laminin γ-3.
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 抗体亚型：
    IgG
  • 纯化方式：
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 产品提供形式：
    Liquid
  • 应用范围：
    WB, IHC, IF, ELISA
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:500-1:2000
    IHC 1:100-1:300
    IF 1:200-1:1000
    ELISA 1:40000
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components.
  • 基因功能参考文献：
    1. LAMC3 gene variation is associated with oral cavity and pharyngeal cancer. PMID: 27749845
    2. We found statistically significant association with AAO for three genes (WRN, NTN4 and LAMC3) with common associated variants. PMID: 26394601
    3. These data suggest that beta2 and gamma3-containing laminins play an important dose-dependent role in development of the cortical pial basement membrane PMID: 22961762
    4. Recessive LAMC3 mutations cause malformations of occipital cortical development. PMID: 21572413
    5. Laminin isoforms containing the gamma3 chain are unable to bind to integrins due to the absence of the glutamic acid residue conserved in the C-terminal regions of the gamma1 and gamma2 chains PMID: 18697739

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  • 相关疾病：
    Cortical malformations occipital (OCCM)
  • 亚细胞定位：
    Secreted, extracellular space, extracellular matrix, basement membrane.
  • 组织特异性：
    Broadly expressed in: skin, heart, lung, and the reproductive tracts.
  • 数据库链接：

    HGNC: 6494

    OMIM: 604349

    KEGG: hsa:10319

    STRING: 9606.ENSP00000354360

    UniGene: Hs.201805