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L3MBTL2 Antibody

  • 货号：
    CSB-PA839279LA01HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Western Blot
      Positive WB detected in: K562 whole cell lysate, Rat heart tissue
      All lanes: L3MBTL2 antibody at 3µg/ml
      Secondary
      Goat polyclonal to rabbit IgG at 1/50000 dilution
      Predicted band size: 80, 70 kDa
      Observed band size: 70 kDa
    • Immunofluorescent analysis of Hela cells using CSB-PA839279LA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) L3MBTL2 Polyclonal antibody
  • Uniprot No.：
    Q969R5
  • 基因名：
    L3MBTL2
  • 别名：
    3bt like 2 protein antibody; 3bt like protein antibody; DKFZP761I141 antibody; H-l(3)mbt-like protein 2 antibody; H-l(3)mbt-like protein antibody; Hl antibody; Hl(3)mbt like protein antibody; Hl(3)mbtl antibody; L antibody; l(3)mbt like 2 (Drosophila) antibody; l(3)mbt like 2 antibody; L(3)mbt-like 2 protein antibody; L(3)mbt-like protein 2 antibody; L3MBTL2 antibody; Lethal antibody; Lethal(3)malignant brain tumor-like 2 protein antibody; Lethal(3)malignant brain tumor-like protein 2 antibody; LMBL2_HUMAN antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human, Rat
  • 免疫原：
    Recombinant Human Lethal(3)malignant brain tumor-like protein 2 protein (1-230AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated

    本页面中的产品，L3MBTL2 Antibody (CSB-PA839279LA01HU)，的标记方式是Non-conjugated。对于L3MBTL2 Antibody，我们还提供其他标记。见下表：

    可提供标记
    标记方式 货号 产品名称 应用
    HRP CSB-PA839279LB01HU L3MBTL2 Antibody, HRP conjugated ELISA
    FITC CSB-PA839279LC01HU L3MBTL2 Antibody, FITC conjugated
    Biotin CSB-PA839279LD01HU L3MBTL2 Antibody, Biotin conjugated ELISA
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    >95%, Protein G purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, WB, IF
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:200-1:2000
    IF 1:50-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Putative Polycomb group (PcG) protein. PcG proteins maintain the transcriptionally repressive state of genes, probably via a modification of chromatin, rendering it heritably changed in its expressibility. Its association with a chromatin-remodeling complex suggests that it may contribute to prevent expression of genes that trigger the cell into mitosis. Binds to monomethylated and dimethylated 'Lys-20' on histone H4. Binds histone H3 peptides that are monomethylated or dimethylated on 'Lys-4', 'Lys-9' or 'Lys-27'.
  • 基因功能参考文献：
    1. L3MBTL2 polymorphism is associated with neuroticism. PMID: 27918536
    2. Our findings highlight a PcG/L3MBTL2 collaboration that attains repressive chromatin without entailing histone lysine methylation marks. PMID: 21596310
    3. High-resolution crystallographic analysis of the four MBT repeats of L3MBTL2 reveals its unique asymmetric rhomboid architecture, as well as binding mechanism, which preclude the interaction of the first three MBT repeats with methylated peptides. PMID: 19233876
    4. determination of the solution structure of the FCS zinc finger of L3MBTL2; structure consists of a beta-hairpin followed by an alpha-helix; structure is consistent with the proposal that FCS zinc fingers bind to regulatory RNAs PMID: 19241375
  • 亚细胞定位：
    Nucleus.
  • 数据库链接：

    HGNC: 18594

    OMIM: 611865

    KEGG: hsa:83746

    STRING: 9606.ENSP00000216237

    UniGene: Hs.517641