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KYNU Antibody

  • 货号：
    CSB-PA621970ESR2HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Western blot
      All lanes: KYNU antibody at 1.44μg/ml
      Lane 1: A549 whole cell lysate
      Lane 2: HepG2 whole cell lysate
      Lane 3: Hela whole cell lysate
      Secondary
      Goat polyclonal to rabbit IgG at 1/10000 dilution
      Predicted band size: 53, 35 kDa
      Observed band size: 53 kDa
    • Immunohistochemistry of paraffin-embedded human liver tissue using CSB-PA621970ESR2HU at dilution of 1:100
    • Immunohistochemistry of paraffin-embedded human placenta tissue using CSB-PA621970ESR2HU at dilution of 1:100
    • Immunoprecipitating KYNU in Hela whole cell lysate
      Lane 1: Rabbit control IgG instead of (1μg) instead of CSB-PA621970ESR2HU in Hela whole cell lysate. For western blotting, a HRP-conjugated anti-rabbit IgG, specific to the non-reduced form of IgG was used as the Secondary antibody (1/50000)
      Lane 2: CSB-PA621970ESR2HU (4μg) + Hela whole cell lysate (500μg)
      Lane 3: Hela whole cell lysate (20μg)
  • 其他：

产品详情

  • 产品描述：
    KYNU polyclonal antibody CSB-PA621970ESR2HU was produced in the rabbit immunized by using the Recombinant Human Kynureninase protein (1-307AA) as the immunogen. The target protein KYNU is a pyridoxal-5'-phosphate (pyridoxal-P) dependent enzyme that catalyzes the cleavage of L-kynurenine and L-3-hydroxykynurenine into anthranilic and 3-hydroxyanthranilic acids, respectively. Kynureninase is involved in the biosynthesis of NAD cofactors from tryptophan through the kynurenine pathway. Diseases associated with KYNU include Hydroxykynureninuria and Vertebral, Cardiac, Renal, And Limb Defects Syndrome 2.
    This Rabbit anti-Homo sapiens (Human) KYNU Polyclonal antibody was tested in the ELISA, WB, IHC and IP applications. The non-conjugated IgG got purified by antigen affinity. It only reacts with the KYNU proteins of human-origin and may be used to detect the endogenous levels of KYNU protein.
  • 产品名称：
    Rabbit anti-Homo sapiens (Human) KYNU Polyclonal antibody
  • Uniprot No.：
    Q16719
  • 基因名：
    KYNU
  • 别名：
    kynU antibody; KYNU_HUMAN antibody; kynureninase (L-kynurenine hydrolase) antibody; Kynureninase antibody; L-kynurenine hydrolase antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Recombinant Human Kynureninase protein (1-307AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen Affinity Purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, WB, IHC, IP
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:1000-1:5000
    IHC 1:20-1:200
    IP 1:200-1:2000
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3-hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3-hydroxyanthranilic acid (3-OHAA), respectively. Has a preference for the L-3-hydroxy form. Also has cysteine-conjugate-beta-lyase activity.
  • 基因功能参考文献：
    1. Our results suggest that tryptophan metabolism might dichotomously modulate immune responses, with KYNU as a switch between immunosuppressive versus inflammatory outcomes. PMID: 26725996
    2. A rare variant at the KYNU gene is associated with essential hypertension in the Han Chinese population. PMID: 22012986
    3. The Lys412Glu polymorphism of the KYNU gene in a hypertensive candidate chromosomal region is associated with essential hypertension in Han Chinese. PMID: 16080802
  • 相关疾病：
    Hydroxykynureninuria (HYXKY); Vertebral, cardiac, renal, and limb defects syndrome 2 (VCRL2)
  • 亚细胞定位：
    Cytoplasm, cytosol.
  • 蛋白家族：
    Kynureninase family
  • 组织特异性：
    Expressed in all tissues tested (heart, brain placenta, lung, liver, skeletal muscle, kidney and pancreas). Highest levels found in placenta, liver and lung. Expressed in all brain regions.
  • 数据库链接：

    HGNC: 6469

    OMIM: 236800

    KEGG: hsa:8942

    STRING: 9606.ENSP00000264170

    UniGene: Hs.470126