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KRT2 Antibody

  • 中文名称：
    KRT2兔多克隆抗体
  • 货号：
    CSB-PA005499
  • 规格：
    ￥880
  • 图片：
    • Western Blot analysis of Jurkat cells using Keratin-pan Polyclonal Antibody
  • 其他：

产品详情

  • Uniprot No.：
    P35908
  • 基因名：
    KRT2
  • 别名：
    KRT2 antibody; KRT2A antibody; KRT2E antibody; Keratin antibody; type II cytoskeletal 2 epidermal antibody; Cytokeratin-2e antibody; CK-2e antibody; Epithelial keratin-2e antibody; Keratin-2 epidermis antibody; Keratin-2e antibody; K2e antibody; Type-II keratin Kb2 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse,Rat
  • 免疫原：
    Synthesized peptide derived from Human Keratin-pan around the non-acetylation site of K185.
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 抗体亚型：
    IgG
  • 纯化方式：
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 产品提供形式：
    Liquid
  • 应用范围：
    WB, ELISA
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:500-1:2000
    ELISA 1:20000
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Probably contributes to terminal cornification. Associated with keratinocyte activation, proliferation and keratinization. Plays a role in the establishment of the epidermal barrier on plantar skin.
  • 基因功能参考文献：
    1. Report genetic/clinical spectrum of KRT2 mutations in keratinopathic ichthyosis. PMID: 26581228
    2. We describe two children with superficial epidermolytic ichthyosis confirmed by genetic testing, including one with a novel mutation. PMID: 22612346
    3. influence of keratinocyte activation, proliferation, and keratinization on K2e expression in samples of cutaneous and oral lesions (keratin K2e) PMID: 12598329
    4. novel H1 domain mutation in a family with icthyosis bullosa Siemens PMID: 17408392
  • 相关疾病：
    Ichthyosis bullosa of Siemens (IBS)
  • 蛋白家族：
    Intermediate filament family
  • 组织特异性：
    Expressed in the upper spinous and granular suprabasal layers of normal adult epidermal tissues from most body sites including thigh, breast nipple, foot sole, penile shaft and axilla. Not present in foreskin, squamous metaplasias and carcinomas. Expressi
  • 数据库链接：

    HGNC: 6439

    OMIM: 146800

    KEGG: hsa:3849

    STRING: 9606.ENSP00000310861

    UniGene: Hs.707