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KREMEN1 Antibody

  • 货号：
    CSB-PA850397ESR2HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Immunohistochemistry of paraffin-embedded human skin tissue using CSB-PA850397ESR2HU at dilution of 1:100
    • Immunohistochemistry of paraffin-embedded human pancreatic tissue using CSB-PA850397ESR2HU at dilution of 1:100
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) KREMEN1 Polyclonal antibody
  • Uniprot No.：
    Q96MU8
  • 基因名：
  • 别名：
    AV002070 antibody; Dickkopf receptor antibody; KREM1_HUMAN antibody; KREMEN antibody; Kremen protein 1 antibody; Kremen protein 1 precursor antibody; Kremen1 antibody; Kringle coding gene marking the eye and the nose antibody; Kringle containing protein marking the eye and the nose antibody; Kringle containing transmembrane protein 1 antibody; Kringle containing transmembrane protein antibody; Kringle domain containing transmembrane protein 1 antibody; Kringle domain-containing transmembrane protein 1 antibody; Kringle-containing protein marking the eye and the nose antibody; KRM1 antibody; RP23 293J16.1 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Recombinant Human Kremen protein 1 protein (180-380AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen Affinity Purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, IHC
  • 推荐稀释比：
    Application Recommended Dilution
    IHC 1:20-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Receptor for Dickkopf proteins. Cooperates with DKK1/2 to inhibit Wnt/beta-catenin signaling by promoting the endocytosis of Wnt receptors LRP5 and LRP6. In the absence of DKK1, potentiates Wnt-beta-catenin signaling by maintaining LRP5 or LRP6 at the cell membrane. Can trigger apoptosis in a Wnt-independent manner and this apoptotic activity is inhibited upon binding of the ligand DKK1. Plays a role in limb development; attenuates Wnt signaling in the developing limb to allow normal limb patterning and can also negatively regulate bone formation. Modulates cell fate decisions in the developing cochlea with an inhibitory role in hair cell fate specification.
  • 基因功能参考文献：
    1. Structure of the dual-mode Wnt regulator Kremen1 and insight into ternary complex formation with LRP6 and DKK1 have been presented. PMID: 27524201
    2. Ectodermal dysplasia including oligodontia is due to homozygosity for KREMEN1 p.F209S (c.626 T>C). PMID: 27049303
    3. Kremen1 has a pro-apoptotic activity that is decreased upon Dkk1 binding or by cancer mutations. PMID: 26206087
    4. Six Dkk-1, three Sost, one Kremen-1 and 10 LRP-5 polymorphisms were significantly associated with radiological progression of rheumatoid arthritis joint destruction. PMID: 23041840
    5. This study demonstrated that a representative tSNP of KREMEN1 might modulate the risk of schizophrenia in the Japanese population. PMID: 20153141
    6. Kremen may not be essential for Dkk1-mediated Wnt antagonism and Kremen may only play a role when cells express a high level of LRP5/6 PMID: 18502762
    7. Functional characterization of related Kremen proteins in mouse. PMID: 12050670

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  • 相关疾病：
    Ectodermal dysplasia 13, hair/tooth type (ECTD13)
  • 亚细胞定位：
    Cell membrane; Single-pass type I membrane protein.
  • 数据库链接：

    HGNC: 17550

    OMIM: 609898

    KEGG: hsa:83999

    STRING: 9606.ENSP00000331242

    UniGene: Hs.229335